To follow up since #VERITAS results have been presented and published in abstract. Navigational #bronchoscopy with the #illumisite system was non-inferior to CT guided TTNA in a multi center RCT for diagnosis of lung nodules and had a much lower complications rate. First time these have been studied in randomized fashion.
Between 8/2021 and 6/2023, 258 patients at seven U.S. sites were randomized and 234 underwent biopsy procedures (Figure 1). Median nodule size was 15 mm (IQR 12-19); 88% (n=205) were in the peripheral third, 82% (n=193) were solid, and 33% (n=78) exhibited a bronchus sign. The primary outcome of diagnostic accuracy wi l be available Summer 2024. Per impending ATS consensus statement, diagnostic yield wi l be the recommended primary endpoint for diagnostic bronchoscopy studies. Accordingly, diagnostic yield, available now, is described below along with safety. NB was diagnostic in 92 of 121 patients (76%) while CT-TTNB was diagnostic in 86 of 113 (76%). The probability that NB was noninferior to CT-TTNB is 97%, exceeding the noninferiority threshold. Complications occurred in 31% of CT-TTNB (n=35) and 5.8% of NB procedures (n=7) (p<0.001). These included PTX requiring tube thoracostomy (8.8%, n=10 vs 0.8%, n=1), PTX not requiring thoracostomy (19.5%, n=22, vs. 2.5%, n=3), and hemorrhage (2.7%, n=3, vs. 0).
Am J Respir Crit Care Med 2024;209:A6665
On the eve of our virtual national meeting @AAB_IP, I want to salute all interventional pulmonologists and bronchoscopists for:
-Continuing to do aerosol generating procedures during COVID
-Caring for cancer patients
-Opening those critically narrowed airways
See you tomorrow!