Ralph

work hard be nice have fun

[Ralph @ralphlee]

@Jon_Mackenzie @JM_Devine Preordered! I can trust a man who uses a recent LinkedIn photo.

[Ralph @ralphlee]

@WeFixKits Looks great, I have a 2010 Bayern kit with the same issue. Do you offer a paid service around this or only DIY videos?

[Ralph @ralphlee]

@matthewherper @adamfeuerstein They're all award wieners

[Ralph @ralphlee]

Arsenal!

https://t.co/zvcS6z4jTp

[Ralph @ralphlee]

Sad to be missing @FootballCliches sold out show during my vacation to London tonight. Managed to arrange alternate plans last minute before flying back to Los Angeles tomorrow :)

[Ralph @ralphlee]

@jhong Ironically, his son's media company Dropout (which is great) is growing pretty rapidly. I wouldn't be surprised if it's valued at 100m.

[Ralph @ralphlee]

@ninjaturtill Who’s punching above their weight here??

[Suzanne E Schindler @SuzanneESchind1]

🩸 🧠 ⏱️ What if a blood test could predict WHEN an individual would develop symptoms of Alzheimer’s disease? High plasma p-tau217 predicts greater risk for Alzheimer’s symptoms—do the plasma p-tau217 levels provide insights into WHEN symptoms might begin?

We found that after a certain level, plasma p-tau217 increased consistently across individuals and allowed creation of “clock” models that could be used to estimate age at p-tau217 abnormality (https://t.co/7v2DppCh4i). The age at p-tau217 abnormality was strongly associated with the age that Alzheimer’s symptoms began. Interestingly, older individuals developed symptoms more quickly after p-tau217 abnormality.

These models are not yet accurate enough to be useful to individuals, but we expect they can be improved by adding additional blood biomarkers and clinical features. We have created an application to view the results (https://t.co/p7P4h0z0zX) and shared all our code to accelerate progress. The eventual goal is to help individuals to understand their likelihood of developing Alzheimer’s symptoms.

@KellenPetersen @FNIH_Org @WashUNeurology @alzassociation #ENDALZ

[ACC Football @ACCFootball]

HE PUNCHED IT OUT 😤

Brent Austin forces the fumble and stops the score!

📺 ESPN x @CalFootball

[Ralph @ralphlee]

@FootballCliches Sold, thanks!

[Ralph @ralphlee]

@FootballCliches Have a pair of Row E tickets for sale - won't be able to make it to London this weekend. Available at face value (below cost) and they are quite close to the front since I got in on the Dreamland presale.

[Ralph @ralphlee]

@EricTopol @TheLancet Wait, are the pbo/lec and pbo/dona lines reversed in your thumbnail? In the oncology graphs, the drug is on top for disease-free survival and progression-free survival

[Ralph @ralphlee]

Excited to have contributed so many of our pts to the leca/dona trials to date! Hopeful that we can continue to move forward in future Alzheimer's treatments just like cancer research has advanced

[Eric Topol @EricTopol]

The revolution in the approach to Alzheimer’s disease for emerging prevention and new treatments, a 3-part series
https://t.co/4rl35mKqMC @TheLancet

[Ralph @ralphlee]

@thantmyintu Any book talks planned in California?

[Ralph @ralphlee]

@nikillinit Just say belli-no

[Ralph @ralphlee]

@ky_lahucik Does MapLight have more cash on hand? https://t.co/lh5iSUADva

[Ralph @ralphlee]

@FootballCliches Zot Zot Zot!

[Ralph @ralphlee]

@SuzanneESchind1 I just got around to reading this, great job with the article. It was nice briefly seeing you at the Intercon in Toronto with @dcweisman

[Ralph @ralphlee]

@jhong check out Tuesday’s NYT crossword - 43 across

[Suzanne E Schindler @SuzanneESchind1]

A thoughtful and sobering piece by Jason Karlawish.

"The problem is that the facts don't support Piller's message. It's sensational, and in my experience, it's causing harm."

Opinion | How a Book Is Undermining Progress Against Alzheimer's https://t.co/6OYoI7V6nc

[Arnold Schwarzenegger @Schwarzenegger]

I don’t really do endorsements. I’m not shy about sharing my views, but I hate politics and don’t trust most politicians.

I also understand that people want to hear from me because I am not just a celebrity, I am a former Republican Governor.

My time as Governor taught me to love policy and ignore politics. I’m proud of the work I did to help clean up our air, create jobs, balance the budget, make the biggest infrastructure investment in state history, and take power from the politicians and give it back to the people when it comes to our redistricting process and our primaries in California.

That’s policy. It requires working with the other side, not insulting them to win your next election, and I know it isn’t sexy to most people, but I love it when I can help make people’s lives better with policies, like I still do through my institute at USC, where we fight for clean air and stripping the power from the politicians who rig the system against the people.

Let me be honest with you: I don’t like either party right now. My Republicans have forgotten the beauty of the free market, driven up deficits, and rejected election results. Democrats aren’t any better at dealing with deficits, and I worry about their local policies hurting our cities with increased crime.

It is probably not a surprise that I hate politics more than ever, which, if you are a normal person who isn’t addicted to this crap, you probably understand.

I want to tune out.

But I can’t. Because rejecting the results of an election is as un-American as it gets. To someone like me who talks to people all over the world and still knows America is the shining city on a hill, calling America is a trash can for the world is so unpatriotic, it makes me furious.

And I will always be an American before I am a Republican.

That’s why, this week, I am voting for Kamala Harris and Tim Walz.

I’m sharing it with all of you because I think there are a lot of you who feel like I do. You don’t recognize our country. And you are right to be furious.

For decades, we’ve talked about the national debt. For decades, we’ve talked about comprehensive immigration reform that secures the border while fixing our broken immigration system. And Washington does nothing.

The problems just keep rolling, and we all keep getting angrier, because the only people that benefit from problems aren’t you, the people. The only people that benefit from this crap are the politicians who prefer having talking points to win elections to the public service that will make Americans’ lives better.

It is a just game to them. But it is life for my fellow Americans. We should be pissed!

But a candidate who won’t respect your vote unless it is for him, a candidate who will send his followers to storm the Capitol while he watches with a Diet Coke, a candidate who has shown no ability to work to pass any policy besides a tax cut that helped his donors and other rich people like me but helped no one else else, a candidate who thinks Americans who disagree with him are the bigger enemies than China, Russia, or North Korea - that won’t solve our problems.

It will just be four more years of bullshit with no results that makes us angrier and angrier, more divided, and more hateful.

We need to close the door on this chapter of American history, and I know that former President Trump won’t do that. He will divide, he will insult, he will find new ways to be more un-American than he already has been, and we, the people, will get nothing but more anger.

That’s enough reason for me to share my vote with all of you. I want to move forward as a country, and even though I have plenty of disagreements with their platform, I think the only way to do that is with Harris and Walz.

Vote this week. Turn the page and put this junk behind us.

And even if you disagree with me, vote, because that’s what we do as Americans. https://t.co/eHFZ723I4H