Very happy to share our latest preprint, where we address the relationship between systemic and gut IgA. See link below and details in 🧵. Huge thanks to everyone involved!
https://t.co/phzAHdAgpS
My lab is looking for an antibody engineer-protein biochemist to study ~500 patient derived monoclonal antibodies. Towards novel insights into autoAb-mediated neurological diseases #encephalitis#nmo#protein#antibody
Come n work at wonderful @MayoClinic Florida🏖️
Pls email me
Collectively, our results suggest that systemic and gut IgA responses against bacteria originate from discrete anatomical sites with inductive sites in the upper aerodigestive tract likely playing a prominent role in generation of systemic IgA.
Very happy to share our latest preprint, where we address the relationship between systemic and gut IgA. See link below and details in 🧵. Huge thanks to everyone involved!
https://t.co/phzAHdAgpS
Notably, while IgA plasma cells in the bone marrow were almost exclusively of the IgA1 subclass, gut plasma cells showed an equal distribution between IgA1 and IgA2.
I am looking for a PhD candidate to join my lab in Oslo! We are trying to understand the role of antigen-specific B cells in autoimmunity. See details and apply here 👇
https://t.co/vbBfbCU0dS
Very excited to share our paper on enzyme-activating BCRs and their role in gluten-sensitive autoimmunity!
https://t.co/FUbLOiUsgg
https://t.co/EkSQMGd7To
We have an open 2-year postdoc position focusing on computational approaches to identify antigen-specific immune receptors from adaptive immune repertoire data. Application deadline: Nov 6. https://t.co/cyIvlclfeU
So excited! Hot off the press in @Nature
We present a human autoimmune organoid model capable of mimicking celiac disease. | driven by Antonio Santos! | Calvin Kuo Lab @StanfordMed
https://t.co/0ZwL9WiNjL
Our paper on the linguistics-based formalization of antibody language is out in @NatComputSci. Work led by @MaiSpaceHa Rahmad Akbar and @PRobertImmodels . Summary thread: https://t.co/5QGruT3T2o.
Happy to share this story on autoreactive naive B cells of relevance to celiac disease. Out now in the Journal of Autoimmunity. More details in 🧵 https://t.co/zHReE2xJ1m
Collectively, our study highlights the role of efficient T cell-B cell collaboration in development of celiac disease and production of disease-specific autoantibodies.
The selected B cells are the ones that can interact productively with gluten-specific T cells. This requires that the B cells bind active TG2, which can form complexes with gluten. Hence, only some epitopes are permissive, and these end up dominating the autoantibody response.
Very happy to share this story on autoreactive B cells in celiac disease together with @IdaLindeman@LeneHoydahl@ChristophAsb @LouiseFRisnes @JCoDiRC. Here, we identify a population of circulating IgA-switched B cells specific to the self-antigen transglutaminase 2 (TG2).
I am so happy to share that our study has been published today in @Nature ! 🎉This has been an absolutely fantastic teamwork between @emilyethornton, @haemyisu@powrie_lab and @teichlab [Link: https://t.co/hMFDLxaTeR]
New opening for a PhD student in my lab, co-supervised with @F_Lund_Johansen . This position is ERC-funded and focuses on novel experimental technologies for antibody-antigen binding screening 📷 https://t.co/T1KmMtxCPS