realArnoldLab

[Kleine-Vehn Lab @KleineVehnLab]

We are looking for a new colleague :)

Please, spread the word!

[Wickstrom-Lab @WickstromLab]

Finally out in print! Check out our study on multiparameter imaging to reveal cancer cell state-dependent crosstalk with stroma that determines patient outcome 👇

[realArnoldLab @realArnoldLab]

BTW, you now also find us here:
@gastrulomicslab.bsky.social

[realArnoldLab @realArnoldLab]

https://t.co/cohVywYo8a

[realArnoldLab @realArnoldLab]

Happy to share latest work from the Lab by lead author Chiara Schröder, out in DevCell: global enhancer remodeling giving competence for mesoderm/endoderm differentiation by co-workers EOMES and SWI/SNF. Transcription comes later! So, EOMES is not a TF, but a chromatin regulator!

[Ina Sonnen @SonnenKatharina]

I am very proud of Yasmine from the lab for winning a poster prize at the #GfE2024 organized by the German and Dutch societies for developmental biology for her work on Hes1 dynamics in the embryonic tail. Congratulations!

[CIBSS @CIBSS_UniFR]

Please RT: Job opportunity!

The Faculty of Medicine at the University of Freiburg, Germany, invites applications for a Full Professorship for Biochemistry and Molecular Biology.
@UniFreiburg @Uniklinik_Fr

https://t.co/7eKksmjL4I

[Alfonso Martinez Arias @AMartinezArias]

WRT the recent interest in TbxT, aka #Brachyury, & all kind of tails, nice historical perspective on this most iconic gene in the history of #DevBio https://t.co/UcVSJBfP9b. Below, heroes of Brachyury (Fig.2 in ref ) + B. Herrmann, who cloned the gene &, of course, the T/+ mouse

[realArnoldLab @realArnoldLab]

Happy to share Tanja‘s new preprint: looking@transcription from quite a different angle: basal TFIID, IDRs and splicing.

[realArnoldLab @realArnoldLab]

@bxv_dev Hurray Geoffrey, great to see this being online! Can’t wait to read it!

[bxv_dev @bxv_dev]

TBX3 is essential to establish the posterior boundary of anterior genes and up-regulate posterior genes with HAND2 during onset of limb bud development https://t.co/c5BxPXfOgV

[Mo Ebrahimkhani @MoEbrahimkhani]

"....Mouse embryos in diapause are sustained by using lipids as primary energy...." source https://t.co/656z5YUWGQ by @bulutkarslioglu and colleagues. also another cool work by Aydan Bulut-Karslioglu and colleagues @NRivron @NiakanLab using this to control dev timing in 🕺🏃‍♀️human https://t.co/UVzmx985uS

[Tschopp Lab @TschoppLab]

We provide further evidence for the downregulation of NOGGIN by pSMAD, as predicted by our simulations, and detail the early antiphasic behavior of GDF5 and pSMAD that result from a self-organizing Turing system that drives joint initiation in developing digits of amniotes... 2/3

[MPI for Molecular Genetics @MPI_MolGen]

📢 Marc Timmers of Universitätsklinikum Freiburg will speak at our #DahlemColloquium!
📜 Basal transcription factor TFIID in neurodevelopment and neurodegeneration
📆 11. DEC, 11:00 AM (CET)
📍 MPIMG , Berlin
🔗 https://t.co/EptZj2PPk5

[Rita Strack @rita_strack]

Very curious if anyone guessed this 😁 Our 2023 Method of the Year is methods for modeling development (aka embryoids)!!!! Some amazing things happening in this space enabling our understanding of the earliest stages of embryogenesis and beyond. Please enjoy the issue!

[Lenne Lab @Equipe_lenne]

Two back-to-back manuscripts on metabolic control of germ layers using gastruloids/stembryos
https://t.co/pv5oxYvkCM by @KStapornwongkul in @LabTrivedi & @EbisuyaMiki
and https://t.co/6UOsOSIndQ in @jvveenvliet!
An exciting time for metabolism and in vitro models of development!

[Alfonso Martinez Arias @AMartinezArias]

The modularity/robustness of #gastruloids to explore rltnshp between #metabolism/#CellFate; 3 #preprints
@teamstembryo @jvveenvliet: https://t.co/XB9eRcuvA0
@KStapornwongkul @LabTrivedi https://t.co/0Lpkj6g7HD
earlier from @dd_chaitanya @BenSteventon2 https://t.co/h6RuJYJbtD

[Asifa Akhtar @AsifaAkhtar1]

Ever considered that the loss of your favorite epigenetic factor might impact gene expression in an allele-specific manner? Our new study shows allele-specific gene regulation by the chromatin regulator MSL2.https://t.co/2XCRZDAcRF

[MPI of Immunobiology & Epigenetics @mpi_ie]

🚨 The lab of @AsifaAkhtar1 uncovered in @nature a mechanism that safeguards the biallelic expression of haploinsufficient genes.

The epigenetic regulator MSL2 acts as an “anti-monoallelic” factor that maintains biallelic gene dosage. This discovery not only reveals a communication system between parental alleles but also points to potential therapeutic strategies for diseases associated with haploinsufficient genes.

Congratulations to @sun_yidan, Meike Wiese & @raedhmadi 🥳

Press release: https://t.co/kBVldhGb5E
Paper: https://t.co/BicJuV287W

[realArnoldLab @realArnoldLab]

@ksedzinski @UCPH_health @reNEW_Global Phantastic News!!! You are a Star!!!