John O'Sullivan

Heart Failure Cardiologist (Central Sydney Cardiology, Royal Prince Alfred Hospital) / Professor of Cardiometabolic Medicine (University of Sydney)

[John O'Sullivan @realjosullivan]

Optimised murine HFpEF models for translational pre-clinical studies https://t.co/aWnP9LeDbS @Sydney_Uni @CPC_usyd @escardio @American_Heart @NEJM @NatureMed @CircAHA @JACCJournals

[John O'Sullivan @realjosullivan]

Despite major advances in HFpEF research, the mechanisms linking age-related vulnerability to the overt expression of the syndrome remain poorly understood. Here we develop a four-hit framework that unifies its principal pathogenic drivers. https://t.co/aWnP9LeDbS

[John O'Sullivan @realjosullivan]

Coming Soon...

[John O'Sullivan @realjosullivan]

Sincere thanks to the National Heart Foundation for their award of a 2-year Vanguard Grant targeting an exciting new inflammatory pathway in Heart Failure, the itaconate-ACOD1-citraconate pathway. @CPC_usyd #FMHUSYD #RPAH #NHF

[John O'Sullivan @realjosullivan]

Huge thanks to the National Heart Foundation for their support with a Level 3 Future Leader Fellowship for the next 4 years. This will enable us to make major inroads into understanding heart failure recovery. @CPC_usyd #FMHUSYD #RPAH #NHF

[John O'Sullivan @realjosullivan]

A new assay we have developed: Rapid On-Demand Point-of-Care Monitoring of Clozapine and Its Metabolite Norclozapine Using Miniature Mass Spectrometry https://t.co/6B078P0jje #mdpipharmaceuticals via @Pharmaceut_MDPI

[John O'Sullivan @realjosullivan]

Incredibly proud that our discovery has been deemed a breakthrough by Nature Cardiovascular Research in their Research Highlights https://t.co/Hd4MAA403h @syd_health #charlesperkinscentre #RPAH #BairdInstitute

[John O'Sullivan @realjosullivan]

@ProfJRMcMullen @syd_health Thanks Julie!

[John O'Sullivan @realjosullivan]

Very excited to share our latest work in the European Journal of Heart Failure detailing the energetic remodelling after mechanical unloading post LVAD in human heart failure, with identification of an important new immunometabolic pathway. @syd_health
https://t.co/lRYCOBsoi1

[John O'Sullivan @realjosullivan]

We are Hiring! We are looking for a motivated research associate to help us advance our murine heart failure models: HFpEF, HFrEF, and everything in between! Come join our talented and wonderful team in the Cardiometabolic Medicine Laboratory!

[Circulation Research @CircRes]

Kaoy et al found #HMGCS2 mediates the therapeutic effects of #NAD+ therapy in #HFpEF by restoring normal lipid metabolism & improving mitochondrial function in the heart. https://t.co/snbdYCdtnj
@yen_koay @realjosullivan @AshishMisraLab @chenchenwenwen

[John O'Sullivan @realjosullivan]

A very well written Editorial on our discovery of the heart's intrinsic ketogenic capacity and how its manipulation can rescue HFpEF, in Circulation Research. #HFpEF #Metabolictherapies
https://t.co/z9MHxi92yF

[John O'Sullivan @realjosullivan]

@rebeccahritchie @CPC_usyd @syd_health @Sydney_Uni Thanks @rebeccahritchie , looking forward to discussing it with you!

[John O'Sullivan @realjosullivan]

The heart IS a ketogenic organ! Specifically, HMGCS2 is critical for normal lipid metabolism and mitochondrial function, and its dysregulation contributes to HFpEF. Very proud of my team! https://t.co/xXdmlIiUU4 @CPC_usyd @syd_health @Sydney_Uni

[John O'Sullivan @realjosullivan]

Delighted to share our new work optimizing protocols aimed to overcome limitations in current murine HFpEF models, improve reproducibility, and enhance clinical relevance. Huge thanks to Bailey McIntosh for this innovative tour de force. https://t.co/GjjxJLI5l7 @yen_koay

[John O'Sullivan @realjosullivan]

Was an honour to present the Grand Rounds at Cork University Hospital, Chaired by my mentor Prof Noel Caplice ⁦@UCC⁩ ⁦@CardiologySyd⁩ ⁦@syd_health⁩

[John O'Sullivan @realjosullivan]

Really looking forward to present Grand Rounds at my alma mater in @CUH_Cork @UCC @Sydney_Uni @syd_health @CardiologySyd @CPC_usyd

[John O'Sullivan @realjosullivan]

Very productive meetings with Roman Rodionov, Stefan Bornstein, and Nikos Perakakis and other work colleagues in the Department of Medicine at @tudresden_de! Very grateful for their expert insights. @Sydney_Uni @syd_health @CPC_usyd

[Circ: Heart Failure @CircHF]

Myocardial proteomic and metabolomic analysis of PPCM reveals unique remodelling and metabolic changes not seen in DCM. @realjosullivan @crisdosremedios https://t.co/EVbjQtXDxJ #AHAJournals

[Gabriele G. Schiattarella @gabrieleschiat1]

@realjosullivan @BIH_Innovation Great having you here @realjosullivan! Everyone - especially the ECIs - loved your talk @crc1470