Results from RESOLVE-1, our Phase 2 trial of oral #NLRP3 inhibitor ruvonoflast, will be presented at the American Heart Association Scientific Sessions in Chicago.
Javed Butler, MD, presents Saturday, November 7, in a Featured Science session.
https://t.co/Ce3lBNHOf3
#AHA2026
A majority of patients with #PeripheralArteryDisease (PAD) carry elevated residual inflammatory risk, even on medication. Later-stage PAD patients can have up to a four-fold increase in cardiovascular death.
https://t.co/cckg8JpA45
#PADAwarenessMonth
We are excited to announce the upcoming launch of our REVEAL-PAD study to investigate the role of inflammation in #PAD and to identify patients who may be eligible for our planned Phase 3 trial of ruvonoflast in PAD.
Read the full press release: https://t.co/UQ5LHbvpj7
We are thrilled to report positive topline results from RESOLVE-1, our Phase 2 trial of ruvonoflast.
Ruvonoflast met the primary inflammation endpoint, with a statistically meaningful reduction in hsCRP at week 24 versus placebo.
https://t.co/Y1OgSLeDLc
#ClinicalTrials
Today, NodThera becomes Rezera.
Rezera's primary focus is the clinical progression of ruvonoflast into a registrational Phase 3 study in #PeripheralArteryDisease (PAD), the first time an NLRP3 inhibitor is being evaluated in Phase 3.
Learn more: https://t.co/RRyXywAK9P
Thank you to Peter Libby and Michael Honigberg for the excellent editorial on our recent publication in @JACCJournals.
Link to our paper (open access) here: https://t.co/HsCPQgUgfL
Link to the editorial: https://t.co/hwzwQ0qbU0
Presented today at #EASCongress2026 and concurrently published in @JACC Journals: ruvonoflast showed a robust and sustained 82% reduction in hsCRP together with improvements in cardiometabolic biomarkers.
PR: https://t.co/PhZzGyZNVo
Publication: https://t.co/HsCPQgUgfL
Our late-breaking EAS 2026 presentation is now available on our website. Learn more about the Phase 1b #ruvonoflast data, including an 82% reduction in hsCRP: https://t.co/qr2lHcai8E
#ASCVD#NLRP3
Ruvonoflast reduced high-sensitivity C-reactive protein and other inflammatory biomarkers at 28 days vs. placebo in certain patients with elevated hsCRP at high CV risk.
#EASCongress 2026 @EASCongress@society_eas@JACCJournals @NodThera
https://t.co/dKKpeqj2cZ
Our CMO, @drjtgeorge, will join leaders across biotech and healthcare to discuss innovation in cardiometabolic disease and inflammation-driven therapies at the 2nd Annual Obesity & Cardiometabolic Innovation Forum (#Sachs_OCIF) on June 5, ahead of #ADA2026.
Ruvonoflast, an oral NLRP3 inhibitor, provides early, sustained, & reversible reductions in #hsCRP & significantly lowers inflammatory biomarkers IL-6 & fibrinogen in cardiometabolic patients with elevated #ASCVD risk https://t.co/HAQsOzox8i
#EASCongress2026#JACC@ProfKausikRay
Presented today at #EASCongress2026 and concurrently published in @JACC Journals: ruvonoflast showed a robust and sustained 82% reduction in hsCRP together with improvements in cardiometabolic biomarkers.
PR: https://t.co/PhZzGyZNVo
Publication: https://t.co/HsCPQgUgfL
Chronic #inflammation is a key driver of ASCVD, even when LDL-C is controlled.
At @NodThera, #ruvonoflast showed sustained reductions in inflammatory biomarkers linked to cardiovascular risk.
Ahead of #EASCongress2026@society_eas, we’re sharing perspectives from @ProfKausikRay
@NodThera will be participating in the upcoming @KeystoneSymp: Immunometabolism in Cardiometabolic Disease and Obesity, taking place March 22–25.
Our CSO, Alan Watt will present our perspective on #NLRP3 Inhibitors for the Treatment of Cardiometabolic Disease and Obesity.
We are looking forward to join the biotech community at #BIOEuropeSpring in Lisbon.
If you’ll be attending, we would welcome the opportunity to connect and discuss how targeting #NLRP3-driven inflammation could open new therapeutic possibilities.