Richard Smith

Cell and Molecular Biologist. Research Scientist @AstraZeneca. Formally Postdoc @Cambridge_Uni and @Stanford

[Alice Ting @aliceyting]

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2 instead of H2O2. We use LaccID for EM imaging of cultured cells and fly brains, and for proteomic mapping of the changing surface composition of T cells that engage with tumor cells via antigen-specific T cell receptors.

[Evgeny Zatulovskiy @Zatulovskiy_E]

A new academic year is here, and we’ve got our first lab photo! Thrilled to welcome Ruyi, who will study size regulation in stem cells, and Owen, who will focus on nucleus size. Big thanks to @RichardJSmith_ for help with lab setup, and to @CamBiochem for the shiny new door sign!

[Richard Smith @RichardJSmith_]

@Zatulovskiy_E @CamBiochem Exciting to be here for the birth of a promising new lab in the cell cycle field! Lots of important decisions to be made in the first phase, just like in cell size regulation! :-p

[Viktorija Smith @Viktorija_SLT]

Officially matriculated! Excited to embark on my PhD at the University of Cambridge as part of my Wellcome Trust Fellowship for healthcare professionals.

[Jakob Nilsson @NilssonLabCph]

Our paper on PP2A-B55 substrate recognition out now. Great collaboration with @FurmanLab @torbenheick @KettenbachLab @jp_arulanandam. We integrate AlphaFold modelling and protein design with biochemical and cell based assays
https://t.co/inySK54baj

[Matthew Swaffer @mpswaffer]

We’re hiring! We have Wellcome-funded postdoc positions to join my group. The project will build on recent work on transcriptional cell size scaling (Swaffer et al. Cell 2023) to ask how gene expression, RNA metabolism and cell signalling are all coordinated with cell size (1/3)

[Jakob Nilsson @NilssonLabCph]

Great collaboration with the @DaveyLab on defining short linear motifs required for cell fitness using base editor screens. Hundreds of novel functional SLiMs to explore!
A proteome-wide dependency map of protein interaction motifs https://t.co/mte7QfiQiY

[Mike Lanz @MikeChuckLanz]

Part 2 of my postdoc work is out! We show that the ploidy-to-cell size ratio is a highly conserved, “intrinsic” determinant of cell physiology. Check out the paper for more insight into how and why.
Link - https://t.co/xYcCOzXcn0
Free PDF – https://t.co/EawctsG3zn
Also, a fun🧵!

[Adrian Saurin @AdeSaurin]

I know it's important to move new drugs into cancer trials as quickly as possible, but we also need to carefully study how these drugs actually work. Otherwise, we'll end up firing shots in the dark.... Read our latest work on a "GSK3 inhibitor" here:
https://t.co/9GR442jgT3

[Evgeny Zatulovskiy @Zatulovskiy_E]

📢🌟 We are looking for a skilled and enthusiastic postdoc to join our lab at Cambridge University (https://t.co/EzFyrptHm3) to study how cell size regulates pluripotency, differentiation and cell cycle in embryonic stem cells 🧫🧬🔬
👉 Apply: https://t.co/6axsCaXqGR 👩‍🔬
Please RT

[Viktorija Smith @Viktorija_SLT]

Excited to have had an opportunity to contribute to this project!

[Jakob Nilsson @NilssonLabCph]

A validation strategy to assess the role of phase separation as a determinant of macromolecular localization: Molecular Cell https://t.co/4No8FMC8Ox

[Adele Marston @Marston_lab]

Great to see this out, congratulations to all the authors and especially @lbkoch9 Also, don’t forget to check out the app for your favourite protein!

[Erik Hoel @erikphoel]

They buried the lede on this new study. It's not that exercise beats out SSRIs for depression treatment, but that *just* dancing has the largest effect of *any treatment* for depression.

That's kind of beautiful.

[Evgeny Zatulovskiy @Zatulovskiy_E]

🔬 Our lab at @Cambridge_Uni is seeking to recruit an enthusiastic and skilled postdoc experienced in stem cell biology to investigate how cell size and cell cycle affect cell fate decisions in self-renewal/differentiation. Please email me if interested (https://t.co/EzFyrpt9wv).

[Jakob Nilsson @NilssonLabCph]

Happy to share our latest efforts on PP2A-B55 in collaboration with @torbenheick @OraFurman @KettenbachLab @jp_arulanandam. We identify a common binding mechanism conferring substrate specificity.
https://t.co/10CORG4obc

[Biotech Connection-Bay Area @BCBAgo]

We are happy to announce the completion of the Viewpoints Fellows program! Our fellows spent the last few weeks crafting articles on current topics in biotech, which you can view here:

https://t.co/wDx8vWyyDb

[Karsten Weis Lab @KarstenWeisLab]

Our commitment to #sustainability has earned our lab a gold 🥇 certification in the @LEAFinLabs program! We've implemented measures to save plastic, water, energy, and more 🌍💚 Sign your lab up today: https://t.co/sdX6HCeRQd
Together we can make a difference! #greenlabs

[Beck Laboratory @Beck_Laboratory]

How can genetic perturbation of a central scaffolding component of the #nuclearpore result in a tissue specific defect? Work by @Reiya_Tan1guch1 and others in collaboration with @DoyeValerie makes this more conceivable (@MPIbp @IJMonod):
https://t.co/PpM1Tw0Rsc

[Phase Transition Papers @Pha_Tran_Papers]

HIV-1 capsids enter the FG phase of nuclear pores like a transport receptor
https://t.co/odoM4TUqHg.