Robbie Myers, MD, PhD

Anatomic Pathology resident @ Mount Sinai Hospital | 🏳️‍🌈 he/him

[Robbie Myers, MD, PhD @RobertMMyers]

it finally happened! utmost thanks to Dan, @FrancoIzzo85, & both past and present members of the @landau_lab for all of the guidance, support, and encouragement along the way. 🎉🍾🥳

[Dan Landau @landau_lab]

Huge congrats to Dr. (!) @RobertMMyers for a beautiful defense and for his incredible ingenuity and tenacity to make the impossible possible 🍾🙌

[Veera Rajagopal  @doctorveera]

A mind-blowing paper has come out today in @Nature

In 2016, JC Venter Institute scientists trimmed a bacterial genome to its barest minimum required for life to synthesize what they called a "minimal genome" (https://t.co/Rk8oZJ0bUj).

Today, a group of scientists from Indiana University reports how that minimal genome evolved over 2000 generations in comparison to the non-minimal genome.

The authors found that even when you reduce a bacterial genome to its absolute minimum where every nucleotide matters, the genome undergoes mutational events generation after generation as much as the non-minimal genome. One simply cannot stop the evolution.

Just over 300 days of evolution (equivalent to 40,000 years in humans) the minimal cell has gained everything it lacked in fitness on day one in comparison to the non-minimal cell.

When comparing the evolved traits between the minimal and non-minimal cells, the scientists found something striking. The evolutionary process increased the cell size of non-minimal cells but not that of the minimal cell. But that is not the striking part.

The scientists were able to identify the key mutation that resulted in cell size evolution. And it turned out that the mutation that helped the non-minimal cells to grow bigger is the same that helped the minimal cells to stay smaller. Growing bigger had a survival advantage for non-minimal cells and not growing bigger had a survival advantage for minimal cells. So, the mutation had a context-dependent effect. This just demonstrates that the evolutionary effects on traits have no absolute direction. All that matter is what is beneficial for the organism's survival.

The conclusion of the paper is metaphorically a quote from the Jurassic Park movie:

“Listen, if there’s one thing the history of evolution has taught us is that life will not be contained. Life breaks free. It expands to new territories, and it crashes through barriers painfully, maybe even dangerously, but . . . life finds a way". (https://t.co/UlxRlb86CT)

https://t.co/zA9OAqSoAu

[Dr. Glaucomflecken @DGlaucomflecken]

The frozen section

[Dan Landau @landau_lab]

This is the day! NIH announced a common fund initiative for somatic mosaicism!

Super excited to join a absolutely dreamy group of ultra smaht scientists

...be still my beating heart...:)

https://t.co/LarsTVEwsP

[Weill Cornell Medicine @WeillCornell]

Team led by Dr. Dan Landau of @WCM_MeyerCancer has received @NIH grant to study somatic mosaicism, a phenomenon in which organs and tissues develop significant genetic differences across their cell populations.

https://t.co/Ewf0D2W5xd

[Jay Shendure @JShendure]

Excited to share our lab's latest preprint, led by @CXchengxiangQIU, @bethkarenmartin & Ian Welsh of @jacksonlab.

We set out to build a single cell roadmap for all of mouse prenatal development, from single cell zygote to free-living pup.

Preprint: https://t.co/GDS65Qf58X 1/n

[Alex Cagan @ATJCagan]

That’s a wrap on #singlecellgenomicsday What a great event for the global research community, thanks @satijalab and @nygenome and all the organisers!

[Dan Landau @landau_lab]

Ringing in the new year with the publication of our SPOTS method for multi-omic spatial transcriptome and protein profiling !

[Weill Cornell Medicine @WeillCornell]

A team led by Dr. Dan Landau (@landau_lab) of @WCM_MeyerCancer uses a new method to map with sharper clarity the gene activity, protein types and locations of cells within organs and tumors.

https://t.co/X19LuLt7iw

[Dan Landau @landau_lab]

Gorgeous 😍 cover @NatureGenet highlighting our work leveraging #SingleCell #MultiOmics to capture the phenotype of human clonal mosaicism!

Extra treat to share an issue with some amazing papers by science role model/heroes @ChrisAWalsh1 @BradEBernstein @mischellab Aviv Regev

[Anna Nam @AnnaEnim]

Cancer driving mutations are detected across normal tissues. But how do you study their downstream effects if the clonal cells can’t be isolated from the admixed normal cells?

Our work on how we tackled this challenge is out today @NatureGenet! https://t.co/MFBW5BbDug

🧵👇

[Robbie Myers, MD, PhD @RobertMMyers]

@AdamStasiw Thank you Adam!!!

[Robbie Myers, MD, PhD @RobertMMyers]

Very proud and excited to say that my thesis work with @FrancoIzzo85 is out on bioRxiv! Check out Dan’s thread to learn more 😁

[Dan Landau @landau_lab]

💃📢¡GoTChA! New pre-print🤯🕺

High throughput single-cell multi-omics platform to jointly capture genotype and chromatin accessibility; charting the differentiation of clonal outgrowths

If you have a moment, would love to tell you all about it 👇

https://t.co/kg5GJPjRgh

[Robbie Myers, MD, PhD @RobertMMyers]

@ApfelbaumApril @FrancoIzzo85 Thank you April!! 🥰

[Dan Landau @landau_lab]

Huge congrats to Neville @nevnevv @TriIMDPhD on his beautiful PhD defense! Extra sweet to have the first student graduate from the lab. I guess now we are a *real* lab...:)

[Dan Landau @landau_lab]

🎶It's raining pre-prints, hallelujah! 🎶
Delighted to share our next generation of ctDNA detection through whole genome mutational aggregation

👉MRD-EDGE 👈

With advanced machine learning signal enrichment we went further and deeper than ever before!

https://t.co/0TZFDia4Zc

[Dan Landau @landau_lab]

🥳new pre-print!🥂
Clonal mosaicism is THE frontier in human genetics. But we know next to nothing about phenotypes of mutated cells in humans. Single-cell multi-omics allowed us to link genotype-phenotype directly in primary human clonal hematopoiesis🎉
https://t.co/my1SQvu6K6

[Robbie Myers, MD, PhD @RobertMMyers]

Happy to have presented some of my thesis work done with @FrancoIzzo85 today @ASH_hematology! Check out the abstract at https://t.co/qppEI3idwm !

[Dan Landau @landau_lab]

So incredibly proud of Robbie Myers @TriIMDPhD for sticking his landing with a prefect 10 delivery of the gorgeous GoT-ChA work with @FrancoIzzo85
+
@fgaiti moderating for extra fun

check out the abstract and talk at https://t.co/rpT7dd1eMD

[Dan Landau @landau_lab]

A thread on GoT; our new platform to link somatic mutations genotyping to @10xgenomics scRNAseq → congrats to @AnnaEnim, @thinktank_Q, Ronan Chaligne et al, with @psmibert wizardry!

Thx @SU2C @LLSusa and #BD2K @NIH_CommonFund for supporting this

https://t.co/PLar6BAmfz

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