@doc_BLocke There was a time when Twitter facilitated (or at least permitted) what you're describing. I think that's long gone, and it's now mainly bad faith engagement and polarized agenda-pushing. I miss when people were at least trying to understand each other.
@DrToddLee@doc_BLocke@nickmmark Would you please link to this metaanalysis of RCTs of pip-tazo vs cefepime in sepsis? I'm not aware of it.
I trust you're being thoughtful about this and not confusing non-abdominal sepsis with febrile neutropenia, which (1) isn't sepsis and (2) is often of gut origin.
@doc_BLocke My email address is [email protected]. It's also in the manuscript. If you have more critiques of our work, I earnestly urge you to reach out to discuss. It'll be more constructive than inadvertently misrepresenting it on social media.
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@doc_BLocke ...we didn't stop there! We tested whether gut microbiota predict AKI in humans (yes) and controlled murine experiments (yes). We also call for prospective human studies. We designed a translational study precisely because of limitations to observational research.
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@nickmmark I think there is still low-hanging fruit all around us. We are just looking at our feet and walking past it. The brain has a lymphatic system. Individual cells have mechanosensation and feel pressure. Adults humans have brown fat. All discovered since I graduated med school.
Wait until these guys find out about pip-tazo!
As someone who solidly believes in the biological potency of the microbiome: "can alter the gut microbiome" is a laughably unserious endpoint. This is so cynical.
We did it!
Absolutely thrilled to share the results of the ASPEN trial published today in @NEJM
Brensocatib(10mg and 25mg vs placebo) reduced exacerbations over 52 weeks and slowed lung function decline
A new treatment for bronchiectasis patients
https://t.co/u94U83zFk6
@nickmmark jesus this is dystopian. it should provoke in us the same pity as AI companions, but instead it gets likes and retweets.
human comfort is more than just a hack for simulating warmth and contact.
(also seems deliriogenic? deliberately disorienting to situation.)