Rod11

I build things—platforms, teams, revenue streams.
Serial entrepreneur—Co-founded npm, Inc. and IDPartner
Our goal is to thrive.

[Rod11 @rod11]

Nothing + quantum fluctuations -> Random somethings

Random somethings together -> Emergent order

Ordered reality + 2nd law -> More entropy

Total entropy ≈> nothing

¯\_(ツ)_/¯

[Rod11 @rod11]

@AlfieJCarter CODE

[Seth Howes @SethSHowes]

I just sequenced a human genome to 30× coverage entirely at home.

As far as I know, this is the first time this has been done.

I didn’t step foot in a lab once. Every step - from saliva collection, to running the sequencer - took place in a single room with a dining table + kitchenette.

Six weeks ago, I had never done wet lab biology before.

I used an Oxford Nanopore P2 Solo - the only commercially available sequencing device portable enough to do 30x human genome sequencing at home.

Biggest takeaway - I could build something that combined software, hardware, and molecular biology far faster than I thought was possible.

I can name >100 specific instances where AI helped me solve a technical problem that would previously have blocked me because I lacked access to a domain expert.

For example: how do I save my sequencing run when my DNA extraction yield is 4x lower than I need it to be, and I have this limited set of reagents to hand?

To make this work, I had to navigate multiple disciplines:

- writing software to monitor sequencing runs and orchestrate remote GPU infra for basecalling
- learning + executing 5 hour long molecular biology protocols
- building a hardware device to quantify DNA concentration

Apologies for the hyperbole, but I feel super lucky to be living in 2026.

A few weeks ago I decided to sequence a human genome to 30x at home.

Then I actually did it. And I did it really quickly.

[Rod11 @rod11]

@AlfieJCarter Carousel

[Owen Brake @OwenBrakes]

The RF world is insane.

Researchers recovered AES-128 keys from a Bluetooth chip by listening to its own antenna from 10 meters away.

Crypto-engine switching noise couples into the RF chain, rides the 2.4 GHz carrier, and leaks out as radio.

[Rod11 @rod11]

Massive police action shutting down the Bay Bridge heading Eastbound.

[Rod11 @rod11]

@AlfieJCarter Claude

[Rod11 @rod11]

@learnwithella Improve - curious

[Rod11 @rod11]

@CharlesMullins2 And here https://t.co/MxvQTeFOKd

[Rod11 @rod11]

@CharlesMullins2 The posts are great. The lack of links ... well, it means it's hard to believe. Why don't you include links, at least in the comments?

[Rod11 @rod11]

@CharlesMullins2 I think this is the paper

https://t.co/A2Egb4OZhQ.

[Rod11 @rod11]

Interesting take. Does Mythos change the economics of software vulnerability research? Perhaps not, but it does raise again the opportunity to remake the open source software landscape in a way that gets developers paid.

[Ananay @ananayarora]

Marcus Hutchins, the guy famous for stopping the WannaCry Ransomware, probably has the best take on Mythos doing vulnerability research

[Rod11 @rod11]

@kunchenguid This is the way. Clearly, the existing approaches don't work. AXI looks very promising.

[Cheng Lou @_chenglou]

My dear front-end developers (and anyone who’s interested in the future of interfaces):

I have crawled through depths of hell to bring you, for the foreseeable years, one of the more important foundational pieces of UI engineering (if not in implementation then certainly at least in concept):
Fast, accurate and comprehensive userland text measurement algorithm in pure TypeScript, usable for laying out entire web pages without CSS, bypassing DOM measurements and reflow

[Rod11 @rod11]

@charl_dot_dev Thanks for posting. Useful. Good demo.

[Rod11 @rod11]

@makatack_ @varun_mathur What could go wrong?

[Rod11 @rod11]

@cs_coville @lefthanddraft Thank you ... that really changes the way I understood the posts.

[Rod11 @rod11]

@lefthanddraft What is "Agape"

[Rod11 @rod11]

@Astro_Jessica Hey - is it because of camera magic (big aperture or long exposure) that these photos show city lights at night, or can you see the city likes with your eyes?

[Rod11 @rod11]

@Astro_Jessica @Space_Station Can you see the city lights at night with the human eye?

Or are those amazing photos and videos of cities on earth taken with special extra sensitive cameras?