Roshan Kumar

Research Investigator @umichmedicine,Biological chemistry,Redox metabolism,Mitochondrial signaling,H2S biology,CRC,IBD #Ruma Banerjee lab,Father

[Roshan Kumar @roshan_kkumar]

Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death: Cell Metabolism https://t.co/Lnifx5Cbjh

[Roshan Kumar @roshan_kkumar]

Full article: Sulfide dynamics at the gut-microbiota interface: diet, oxygen and redox interplay https://t.co/hUDIsDqncI

[Roshan Kumar @roshan_kkumar]

@rashi_singhal7 @ajybhat @NIHAging @Leiserlab @UMPhysiology Congrats Ajay!

[Roshan Kumar @roshan_kkumar]

@UMICHpancreas @radykm @NIGMS Congrats Megan!

[Nature Metabolism @NatMetabolism]

Online now! H2S as a metabolic saboteur https://t.co/Cynb6pv18o

[Roshan Kumar @roshan_kkumar]

Congratulations💐

[Dan Michele @MicheleLabUM]

Congratulations to Dr. Costas Lyssiotis (@LyssiotisLab) from all of your colleagues in @UMPhysiology for your successful promotion to full Professor. #GoBlue

[Roshan Kumar @roshan_kkumar]

Congrats Nupur!

[Shah Lab @YatrikShahLab]

Huge congrats!!

[Roshan Kumar @roshan_kkumar]

Congratulations Hannah!

[Hannah Bell @Hannah_N_Bell]

So excited that our review article on the role of ferroptotic cell death in immunity is finally out! Check it out to learn how this iron dependent cell death pathway regulates immune responses in tumors, autoimmunity, infection and homeostasis. @bstockwell @ImmunityCP

[Krishna Singh Bisht @Krishna_SBisht]

Latest from the Laboratory of Functional Proteomics @unescorcb. Heartiest Congratulations 🎉🥳🎉to @sushant16m8 and the team @SahaSandhini @Ranikisbt @Tushar_RCB.
@jbiolchem
https://t.co/JsDvEcjvq0

[Raniki Kumari @Ranikisbt]

Exploring more amyloidogenic proteins?? In our first study we showed Otub1, a deubiquitinating enzyme has a huge potential to form an amyloid and potentiates co-aggregation of alpha-synuclein. our recent publication described the mechanistic insights of Otub1 amyloid aggregation

[Sushant Majumder @sushant16m8]

@Tushar_RCB @SenSobhan @SahaSandhini @Ranikisbt @PhdError @jbiolchem
Hotspot site microenvironment in the deubiquitinase OTUB1 drives its stability and aggregation
https://t.co/88wVdG5JTs

[Roshan Kumar @roshan_kkumar]

Our work is online now @jbiolchem. We have developed a methodology to capture coenzyme Q redox state. Credit goes to Victor Vitvitsky.
Rapid HPLC method reveals dynamic shifts in coenzyme Q redox state - Journal of Biological Chemistry https://t.co/xrWkOuEanJ

[Roshan Kumar @roshan_kkumar]

@ajybhat @YatrikShahLab @UMPhysiology Congrats 👍

[Roshan Kumar @roshan_kkumar]

Lay perspective of our work covered by ⁦⁦@umichmedicine⁩ https://t.co/yjBeHo793m

[Roshan Kumar @roshan_kkumar]

Synergizing with hypoxia, SQOR deficiency induces a reductive shift in the ETC and
restricts proliferation.
SQOR KO mice exhibit lower neovascularization in tumor xenograft and hind limb
ischemia models.

[Roshan Kumar @roshan_kkumar]

I'm thrilled to share, our work is online now @nchembio. Huge thanks to Ruma Banerjee, @YatrikShahLab @lyssiotis and all authors @rashi_singhal7 @SumeetASolanki @SAlibeckoff @Hannah_N_Bell and others.https://t.co/axn3J7htNS

[Roshan Kumar @roshan_kkumar]

Hypoxic induction of •NO in endothelial cells inhibits CBS and switches CTH reaction
specificity.
Hypoxic interruption of the canonical transsulfuration pathway promotes H2S synthesis.

[Roshan Kumar @roshan_kkumar]

Congrats @dhanna194 @diesejutter for this wonderful study explaining the effect of sulfide and oxygen intersection on metabolism. H2S preconditioning induces long-lived perturbations in O2 metabolism | PNAS https://t.co/CUWYgM3F1o

[Roshan Kumar @roshan_kkumar]

@BrandonTWChen @YatrikShahLab @LyssiotisLab Congratulations!

[Roshan Kumar @roshan_kkumar]

Congratulations @rashi_singhal7 @YatrikShahLab 😊

[Rashi Singhal @rashi_singhal7]

Our study where we show role of neutrophil specific HIF2a in colitis-associated cancer is selected for APSselect award in @ajpgi. Proud moment for @YatrikShahLab. Thanks to @APSPhysiology