Congratulations to Dr. Costas Lyssiotis (@LyssiotisLab) from all of your colleagues in @UMPhysiology for your successful promotion to full Professor. #GoBlue
So excited that our review article on the role of ferroptotic cell death in immunity is finally out! Check it out to learn how this iron dependent cell death pathway regulates immune responses in tumors, autoimmunity, infection and homeostasis. @bstockwell@ImmunityCP
Exploring more amyloidogenic proteins?? In our first study we showed Otub1, a deubiquitinating enzyme has a huge potential to form an amyloid and potentiates co-aggregation of alpha-synuclein. our recent publication described the mechanistic insights of Otub1 amyloid aggregation
Our work is online now @jbiolchem. We have developed a methodology to capture coenzyme Q redox state. Credit goes to Victor Vitvitsky.
Rapid HPLC method reveals dynamic shifts in coenzyme Q redox state - Journal of Biological Chemistry https://t.co/xrWkOuEanJ
Synergizing with hypoxia, SQOR deficiency induces a reductive shift in the ETC and
restricts proliferation.
SQOR KO mice exhibit lower neovascularization in tumor xenograft and hind limb
ischemia models.
Hypoxic induction of •NO in endothelial cells inhibits CBS and switches CTH reaction
specificity.
Hypoxic interruption of the canonical transsulfuration pathway promotes H2S synthesis.
Congrats @dhanna194@diesejutter for this wonderful study explaining the effect of sulfide and oxygen intersection on metabolism. H2S preconditioning induces long-lived perturbations in O2 metabolism | PNAS https://t.co/CUWYgM3F1o
Our study where we show role of neutrophil specific HIF2a in colitis-associated cancer is selected for APSselect award in @ajpgi. Proud moment for @YatrikShahLab. Thanks to @APSPhysiology