Roy Rabbie

Academic medical oncologist | PhD @SangerInstitute | Clinical computational oncology

[Roy Rabbie @RoyRabbie]

Loved being part of this ambitious project and exceptional team!

[richard white @whitefishlab]

A question that has long obsessed us: are the "seeds" of metastasis built into the primary tumor? In our new paper ,@shruthy_suresh tackled this question by combining human transcriptomics with the #Zebrafish TEAZ method to come up with the answer: https://t.co/iK6YcmB9mn

[Roy Rabbie @RoyRabbie]

Really enjoyed working on this alongside @whitefishlab, @DoreenLau4 and @David_J_Adams!

[Genome Biology @GenomeBiology]

Editorial from @RoyRabbie, @David_J_Adams and co, discussing how genomics techniques can help us work out how tumors interact with their microenvironment, and in particular how single-cell techniques have revolutionized the field https://t.co/qP3V8Rjr1k

[David Adams @David_J_Adams]

Come and join us! Happy to Zoom with any bioinformatician interested in coming to work in my group at Sanger - you could also ask former bioinformaticians including @IauraRiVA @daniela_oaks @Mamun__Rashid @RoyRabbie @stefan_seq

https://t.co/saV1cfA9zj

[richard white @whitefishlab]

really interesting approach to genetic redundancy in cancer: combinatorial screens of gene "pairs". bet this general idea applies to lots of situations. congrats to @David_J_Adams lab for this great new paper: https://t.co/w19GG8ABUz

[Roy Rabbie @RoyRabbie]

Excited to share our work on gene expression profiles in primary melanoma from a Ph3 adjuvant trial! Congrats @manik_garg_1! Thank you to our outstanding collaborators Prof Julia Newton-Bishop, @ProfRScolyerMIA, @ProfGLongMIA, @SerineLo, @jonsson_lab & @JWilmott38.@David_J_Adams!

[Manik Garg, PhD @manik_garg_1]

Our work is now published! 🎉Many thanks to everyone involved, especially @RoyRabbie @ABrazma, @David_J_Adams, Dr. Dominique-Laurent Courturier @CRUK_CI and the @NatureComms editorial and peer-review team for helping us strengthen our results. (1/3) https://t.co/YEfXjSfRb1

[David Adams @David_J_Adams]

With generous support from the @The_MRC we launch the Dermatlas Project. Happy to work with groups who have interesting/novel collections of skin tumours.

https://t.co/9NYl18cvZm

[Roy Rabbie @RoyRabbie]

@TurajlicLab @BrJCancer @ProfRScolyerMIA @ProfGLongMIA @MelanomaAus @nyulangone @David_J_Adams Transgenic mouse models may have some limitations in this regard, and we are currently exploring other approaches including #zebrafish!

[Roy Rabbie @RoyRabbie]

Really pleased to share our study exploring the mutational landscape of melanoma brain metastases @BrJCancer! A fantastic collaboration with Peter Ferguson, @ProfRScolyerMIA & @ProfGLongMIA @MelanomaAus and Iman Osman @nyulangone! Led by @David_J_Adams!
https://t.co/LQeds7I0sK

[Roy Rabbie @RoyRabbie]

@TurajlicLab @BrJCancer @ProfRScolyerMIA @ProfGLongMIA @MelanomaAus @nyulangone @David_J_Adams Thank you! Absolutely, as previously reported these early-brain metastases were represented by thin primaries (median BT 1.5mm) and a very long disease-free interval (median 3.3yrs from primary -> brain metastasis)!

[Roy Rabbie @RoyRabbie]

@fairfaxlab @NatureComms A repeat scan 2 weeks later (due to progressive symptoms) showed widespread extracranial PD and although targeted panel seq subsequently revealed a BRAFV600R mutation, patient was no longer clinically suitable for systemic therapy and chose to be manage with best supportive care

[Roy Rabbie @RoyRabbie]

Our work on clonal evolution in melanoma is out @NatureComms! Genome-wide analyses of multiple metastases sampled at autopsy followed by multisite analyses from a patient series allowed us to take a deeper look into heterogeneity.[1/8] https://t.co/3DRF0Nx9IP

[Roy Rabbie @RoyRabbie]

@fairfaxlab @NatureComms Thank you. The patient presented some time ago with symptomatic intracranial recurrence and BRAFV600E IHC was negative and we did-not have data on the effectiveness of BRAF/MEKi in intracranial disease at the time and so proceeded with WBRT.

[Roy Rabbie @RoyRabbie]

We would like to thank the the patients and their families and particularly the index patient, whose altruism inspired every aspect of this work.[8/8]

[Roy Rabbie @RoyRabbie]

This study was an excellent partnership with @NaserAnsariPour and includes the work of @Ollie_Cast, @DoreenLau4, @IauraRiVA, @luiza_moore, @theslimmingdoc, @FerdiaGallagher, @MillerLab4 and lead by @davidcwedge and @David_J_Adams.[7/8]

[Daniela Robles @daniela-oaks.bsky.social @daniela_oaks]

Happy that our review on #melanoma subtypes has been useful and was recognised as a #TopDownloadedArticle in @JPathology! We even got a shiny certificate 😄 @RoyRabbie @Christian_moli_ @David_J_Adams
See review here 👉https://t.co/17eV4eIq7Z