Radek Nowak

Professor @UniBonn. Former @DanaFarber @harvardmed | Targeted Protein Degradation | Chemical and Structural Biology | @UniofOxford alumni. Tweets are my own.

[Radek Nowak @RPNowak]

Targeted protein #degradation: from mechanisms to #clinic. New molecular mechanisms can rapidly be translated - we can learn so much from nature.
Great to be able to share this piece with @jonathanMtsai Ben Ebert and Eric Fischer @fischerlab1. #TPD https://t.co/Czk3aeQ7td

[Radek Nowak @RPNowak]

@biomiko in Bonn! #tpd #molecularglues

[Hojong Yoon @hojong_yoon]

Excited to share our latest work published today!

https://t.co/G05ySKf9FL

[Lyn Jones @LynJonesChemBio]

New bioRxiv preprint: covalent remodeling of CRBN locks His353 in a conformation that avoids the IMiD clash and polarizes the C2–H to form a new edge‑to‑face interaction with NTAQ1 Phe126. #TargetedProteinDegradation #MolecularGlue https://t.co/g331OlG1PL

[Katherine A Donovan @kdonovan1008]

Beautiful work identifying a novel degron-independent neo-substrate of CRBN, led by the KAT2A team — Samuel Ojeda and Meng Wang of the @fischerlab1!! Congrats to all involved!

https://t.co/Od1uLyRKjK

[Charlie Harris @charlieharris01]

NEW: today OpenBind ‘comes out of stealth’ so to speak with their first data dump of ~900 novel protein-ligand structures - most with paired affinities

This represents a meaningful %-age increase in all of humanities P-L data in the PDB collected in the last 50 years

More👇

[Ingo Hartung @HartungIngo]

Nathanael Gray @StanfordUChem about bifunctional proximity-inducing molecules which allow to rewire transcription #AACR26. TCIPs hijacking BCL6, BRD4, CDK9, p300 and p53 Y220C as “synthetic hybride TFs” leading to transcriptional hyperactivation & gain-of-function pharmacology.

[Katherine A Donovan @kdonovan1008]

📢 Save the Date for our DFCI Targeted Protein Degradation in-person Meeting!!

📍 Location: Boston, MA
📅 Date: September 10th, 2026
🔬 Talks from leaders in the field
🤝 Networking reception
🌍 Livestream available

[Radek Nowak @RPNowak]

Our new lab website is live! 👉 https://t.co/91TSBWYDTk
We are looking for a postdoc in #structuralbiology / #cryoEM to join our lab at the University of Bonn @UniBonn.
Please share or reach out!

[Nature Reviews Drug Discovery @NatRevDrugDisc]

Induced proximity-based therapeutic modalities
https://t.co/hzBGTQEVyt
https://t.co/Y7toX848yE

This new Review discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more

[Radek Nowak @RPNowak]

Was so much fun to be part of that journey! So much for the exciting science and most importantly friendships. To the next 10! @fischerlab1

[Katherine A Donovan @kdonovan1008]

This month we celebrated a decade of the @fischerlab1 - 10 years of discovery, innovation, and collaboration!

Thank you to everyone who’s been part of this journey — past and present lab members, collaborators, and supporters.

Here’s to the next 10! 🧪🎉

[Radek Nowak @RPNowak]

Excited to present our research at the Promega TPD and Induced Proximity Summit this Thursday!

#TPD #UniBonn

https://t.co/BJ6Ku0uGeb

[Steven Corsello @corsellos]

Excited to share our discovery of potent TRIM21 molecular glues with anticancer activity, online today @CD_AACR: "Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex". 1/18

[Dana-Farber News @DanaFarberNews]

A new study in @MolecularCell by @DanaFarber’s @biomiko, Benjamin Ebert, MD, PhD, and @fischerlab1 reports a systematic screen of 9,000 zinc fingers revealing 38 new CRBN-recruited degrons. This includes targets invisible to proteomics, expanding the ZF proteome map to guide drug design and mitigate off-target toxicity.

Read more: https://t.co/ho9ICb22HA

[Mikołaj Słabicki @biomiko]

@DanaFarber @DanaFarberNews @broadinstitute @MassGeneralNews

[Mikołaj Słabicki @biomiko]

Thanks to all co-authors:
@jeanniescience Simran Rastogi, Anna Goldstein, ​ Marek Nagiec, Kathrine Donovan, Jianwei Che, Moritz Hunkeler, Chi-Lin Hsu, Megha Lakshminarayan, Chelsea Shu @beckyzon @zkozicka Paul Park @jonathanMtsai @hojong_yoon @LynJonesChemBio @adamssperling

[Mikołaj Słabicki @biomiko]

This work was a fantastic collaboration:
🔬Structure: @jihojasonpark, @RPNowak, @ssroyburman - @fischerlab1
🧬 Functional Genomics: JessePellman, CharlesZou - Ebert lab
⚗️Chemistry: Hlib Razumkov, Qixiang Geng (Gray lab)

[Mikołaj Słabicki @biomiko]

A single ZF residue can switch a drug’s specificity. That’s a lever for rational molecular‑glue design.

[Mikołaj Słabicki @biomiko]

Chemistry rewires biology: subtle changes to glutarimide analogs reshape degron selectivity, reprogramming CRBN toward new ZF targets.

[Mikołaj Słabicki @biomiko]

Structure + mutagenesis reveal distinct CRBN recruitment modes—different substrates or drugs interact with different CRBN surfaces.

[Mikołaj Słabicki @biomiko]

CRBN is more versatile than expected: potent degraders can overcome β-hairpin mutations and still engage substrates.