🧩 New paper out in Nature Communications!
"Unveiling the hidden interactome of CRBN molecular glues"
Huge thanks to our incredible team and collaborators who made this possible!
📖 Read the full open-access article here: https://t.co/iuTyDM24Vs
We keep stumbling on molecular glues, but how can they be made for a pre-selected target? We’ve been working on this question, envisioning a high-throughput chemistry (HTC)-based approach to convert pre-existing ligands into molecular glues. https://t.co/7ppA24BQVK
A new paper from Benjamin Ebert, Nathanael Gray, @eric_fischer, @fischerlab1, @LiYender, Michelle Ma, and @M_MurtazaHassan reports a trans-labeling mechanism “template-assisted covalent modification”, which enables proximity-driven pharmacology https://t.co/VvAJdpgDIf
Excited to share our story on polymerization in ZBTB transcription factors, which was published in the July 11 issue of @MolecularCell! https://t.co/qlzxfF0PR4 1/n
We are looking for a couple of Research Technicians to join us in the @fischerlab1! If you enjoy biochemistry/chem bio and are interested in working in a great team exploring degrader induced interactions and degradation reach out or apply:
https://t.co/JTgH6CfuUA
Please RT!
#AlphaFold can accurately predict PP2A complexes! We solve the structure of #PP2A A R5E C complex and show that PP2A phosphatase assembly is independent of the C subunit methylation. Great team with amazing @FranziskaWacht1@fischerlab1#Xray
https://t.co/e9jlFohuZL
Just in time for #HumpDay: Our study Targeting DCAF5 suppresses #SMARCB1-mutant #cancer via stabilizing SWI/SNF is online now in @Nature. Congratulations 🎉 to co-first authors Sandi-Radko-Juettner and @HongYue88665668 and all co-authors on this story! 1/
https://t.co/f3fJfiPjiM
Excited to share E3-substrate tagging by ubiquitin biotinylation (E-STUB) @nchembio! E-STUB enables CUL-RING ligase substrate identification and may transform the way we study glues and PROTACs by directly studying substrate ubiquitylation. 1/
https://t.co/et7SkRjds8
We are delighted to welcome a new class of Damon Runyon Fellows! Learn more about these talented researchers and the questions they'll work to answer as Damon Runyon scientists: https://t.co/KQ0ZLYNC0I
Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology.
PDF: https://t.co/cCVLKL0w8Y
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We are looking for a postdoctoral research fellow to work with Eric Fischer and myself to pioneer next-generation covalent drug discovery. Please retweet. Apply here: https://t.co/BucBEiSGW2 @fischerlab1
Don’t miss out on attending the Keystone Targeted Protein Degradation and Proximity Therapeutics, January 21-24, 2024 🧬⛷️👩💻
Abstract deadline is October 26.
Targeted Protein Degradation
https://t.co/ZCTkD6oXh4
Proximity Based Therapeutics
https://t.co/QlT0hL4PrK
This week in the TPD seminars we are hosting two excellent speakers @KheewoongBaek and @LukasHenneberg sharing stories from work completed in Prof. Brenda Schulman's lab at Max Planck Institute for Biochemistry !
See you at 11am EST!!!