Fischer Lab

News and updates from the Eric Fischer Lab, Est. Oct 2015 @DanaFarber @harvardmed | E3 Ligases | Ubiquitin | Degraders | Chemical Biology | Cancer

[Katherine A Donovan @kdonovan1008]

🧩 New paper out in Nature Communications!

"Unveiling the hidden interactome of CRBN molecular glues"
Huge thanks to our incredible team and collaborators who made this possible!
📖 Read the full open-access article here: https://t.co/iuTyDM24Vs

[Michael Erb @Michael_A_Erb]

We keep stumbling on molecular glues, but how can they be made for a pre-selected target? We’ve been working on this question, envisioning a high-throughput chemistry (HTC)-based approach to convert pre-existing ligands into molecular glues. https://t.co/7ppA24BQVK

[Michael Erb @Michael_A_Erb]

This project was led by postdoc Jamie Shaum and assisted by so many friends (to whom we are most grateful): @georg_e_winter, @fischerlab1, @alessiociulli, @Armstrong_dfci, @alessiociulli, Seiya Kitamura, @brumelillo, @EngleLab, and Ben Cravatt. (8/end)

[Nature Chemical Biology @nchembio]

A new paper from Benjamin Ebert, Nathanael Gray, @eric_fischer, @fischerlab1, @LiYender, Michelle Ma, and @M_MurtazaHassan reports a trans-labeling mechanism “template-assisted covalent modification”, which enables proximity-driven pharmacology https://t.co/VvAJdpgDIf

[Jiho Park @jihojasonpark]

Tune in for a polymerization-themed doubleheader from me, Paul, and @MSuskiewicz this Thursday at 11am EDT!

[Jiho Park @jihojasonpark]

Excited to share our story on polymerization in ZBTB transcription factors, which was published in the July 11 issue of @MolecularCell! https://t.co/qlzxfF0PR4 1/n

[Dana-Farber Cancer Biology Department @DFCI_CancerBio]

Nice DFCI Insight blog post about Sidney Farber Fellow @FranziskaWacht1 who will be conducting her research in @fischerlab1
https://t.co/7hffLSpuW3

[Katherine A Donovan @kdonovan1008]

We are looking for a couple of Research Technicians to join us in the @fischerlab1! If you enjoy biochemistry/chem bio and are interested in working in a great team exploring degrader induced interactions and degradation reach out or apply:
https://t.co/JTgH6CfuUA

Please RT!

[Radek Nowak @RPNowak]

#AlphaFold can accurately predict PP2A complexes! We solve the structure of #PP2A A R5E C complex and show that PP2A phosphatase assembly is independent of the C subunit methylation. Great team with amazing @FranziskaWacht1 @fischerlab1 #Xray
https://t.co/e9jlFohuZL

[Fischer Lab @fischerlab1]

Congratulations @FranziskaWacht1 🎉👏

[Dana-Farber Cancer Biology Department @DFCI_CancerBio]

Congratulations @FranziskaWacht1 in @fischerlab1 for receiving the 2024 Sidney Farber Scholar Award!!

[The Roberts Lab @TheRobertsLab1]

Just in time for #HumpDay: Our study Targeting DCAF5 suppresses #SMARCB1-mutant #cancer via stabilizing SWI/SNF is online now in @Nature. Congratulations 🎉 to co-first authors Sandi-Radko-Juettner and @HongYue88665668 and all co-authors on this story! 1/
https://t.co/f3fJfiPjiM

[Hubert Huang @hai_tsang_huang]

Excited to share E3-substrate tagging by ubiquitin biotinylation (E-STUB) @nchembio! E-STUB enables CUL-RING ligase substrate identification and may transform the way we study glues and PROTACs by directly studying substrate ubiquitylation. 1/
https://t.co/et7SkRjds8

[Fischer Lab @fischerlab1]

Congratulations @KheewoongBaek 👏🎉

[Damon Runyon Cancer Research Foundation @DamonRunyon]

We are delighted to welcome a new class of Damon Runyon Fellows! Learn more about these talented researchers and the questions they'll work to answer as Damon Runyon scientists: https://t.co/KQ0ZLYNC0I

[Fischer Lab @fischerlab1]

Great to see this story out - congrats to the team 🎉

[David R. Liu @davidrliu]

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology.
PDF: https://t.co/cCVLKL0w8Y
1/13

[Lyn Jones @LynJonesChemBio]

We are looking for a postdoctoral research fellow to work with Eric Fischer and myself to pioneer next-generation covalent drug discovery. Please retweet. Apply here: https://t.co/BucBEiSGW2 @fischerlab1

[Fischer Lab @fischerlab1]

Another incredibly fun @HMS_BCMP retreat - we decided to become the UPS this year!!

[Radek Nowak @RPNowak]

NEWS! I'm excited to share that I'm joining @IsbBonn @UniklinikBonn @UniBonn @ImmunoSens as a professor to start my LAB! We are open for business and #hiring for #postdoc #tech positions! #NewPI #MoveToGermany #UniBonn #TPD #InducedProximity Please share! https://t.co/91TSBWYDTk

[Fischer Lab @fischerlab1]

Don’t miss out on attending the Keystone Targeted Protein Degradation and Proximity Therapeutics, January 21-24, 2024 🧬⛷️👩‍💻
Abstract deadline is October 26.

Targeted Protein Degradation 
https://t.co/ZCTkD6oXh4

Proximity Based Therapeutics
https://t.co/QlT0hL4PrK

[Katherine A Donovan @kdonovan1008]

This week in the TPD seminars we are hosting two excellent speakers @KheewoongBaek and @LukasHenneberg sharing stories from work completed in Prof. Brenda Schulman's lab at Max Planck Institute for Biochemistry !
See you at 11am EST!!!

[Katherine A Donovan @kdonovan1008]

We have exciting new updates to our schedule for the free TPD in-person event on September 14th!
Register on our webpage and see you soon!!