Yen-Der Li

Passionate about science, medicine, and business

[RTW Investments, LP @RtwLp]

RTW Investments recently hosted our RTW Intern Alumni Night! Current interns had the opportunity to relax, network, and hear from accomplished alums who shared their experiences and career insights.

[Nature Chemical Biology @nchembio]

A new paper from Benjamin Ebert, Nathanael Gray, @eric_fischer, @fischerlab1, @LiYender, Michelle Ma, and @M_MurtazaHassan reports a trans-labeling mechanism “template-assisted covalent modification”, which enables proximity-driven pharmacology https://t.co/VvAJdpgDIf

[MCB_Harvard @MCB_Harvard]

Congratulations to ALL 2023 Graduates! @HarvardGSAS @HasreetGill @anuraglimdi @GalLumbroso @KalkiKukreja @min_jiseon @Ju_Brr @sylviahurlimann @KumareshSpikes @LiYender https://t.co/m5ujsuflyU

[Mikołaj Słabicki @biomiko]

DCAF16-focused seminars are now available online:
https://t.co/CQO5bxkExy
https://t.co/03RwPYkfDC

[Mikołaj Słabicki @biomiko]

1/8 💡🦠 Can we harness human E3 ligases for antiviral defense? Are human E3 ligases involved in maintaining SARS-CoV-2 virus stability? Our pandemic research project is finally published! #COVID19 #E3Ligase https://t.co/wZdZL0rNIr

[Dan Nomura @DanNomura]

Excited to see our @ACSCentSci paper published on rational design of molecular glue degraders via a transplantable covalent handle! Congrats to @EthanToriki, @JPapatzimas, @NovartisScience, and team! Thanks also to @TheMarkFdn! @UCB_Chemistry https://t.co/i3VQ8d4q89

[Mikołaj Słabicki @biomiko]

Join for DCAF16-focused seminars:
Yen-Der Li @LiYender (Ebert Lab), Michelle Ma (@fischerlab1), and Muhammad Murtaza Hassan @M_MurtazaHassan (Gray lab).
As well as Matthias Hinterndorfer @_matthias_h (@georg_e_winter), Ollie Hsia @ollie_lh, and Angus Cowan (@alessiociulli lab)

[Dan Nomura @DanNomura]

Congrats to our @UCB_Chemistry chem bio graduate @Ellie_King13 for her @CellChemBiol publication on using chemoproteomic approaches to discover a covalent molecular glue degrader that exploits an E2 UBE2D to degrade NFKB1! Glad to have this published!
https://t.co/KNFfDZuYO1

[Fischer Lab @fischerlab1]

1/9 What happens when covalent chemistry meets molecular glue? The Ebert Lab, @fischerlab1, and Gray Lab discovered a trans-labeling covalent mechanism we termed “template-assisted covalent modification” from a new class of DCAF16-based BRD4 degraders.https://t.co/1ybOLErbPf

[Ingo Hartung @HartungIngo]

A study by @genentech with huge implications for #TPD & #PROTAC space (efficacy & safety): Induced degradation of certain proteins generates peptides which bind to & induce cIAP1 autodegradation, leading to caspase activation & cell death. @biorxivpreprint https://t.co/zRJGObpEsW

[Andrew Pannu @andrewpannu]

Gene therapy landscape

I pulled together 42 public companies and charted the preclinical & clinical assets of each, segmented by approach & vector

Some takeaways:

[Yen-Der Li @LiYender]

https://t.co/LhFPz9RcTu

[Stephan Hacker (inactive account) @StephanHacker2]

Great paper by the group of @georg_e_winter in @J_A_C_S. They establish a luciferase-based screening platform that allows the systematic identification of new E3 ligases amenable to molecular glue design as well as their degradation targets. https://t.co/WPMK1gmeaV

[NH BAE @ghostbnh]

A very informative read!
Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction

Drs. Jaeki Min P. Ryan Potts, Ph.D. Congratulations!
https://t.co/dIfqjJkzey https://t.co/QgbehY6s7s

[Hojong Yoon @hojong_yoon]

I've always been somewhat skeptical about bifunctional modalities due to their "expected" poor PK/PD, but many molecules surprised me with their superior efficacy despite their bizarre shape, and now we got some clues - groundbreaking work from @kevansf

https://t.co/VLOF09f9o8

[Joazeiro Lab @LabJoazeiro]

How cool is that? New paper @Nature, E3 #ubiquitin ligases keep on giving
#Proteindegraders #PROTACs
https://t.co/KEATySnN7q

[Stuart Schreiber @SchreiberStuart]

6/11. This point was emphasized in research from Haian Fu's lab at Emory where missense oncogenic alleles were found to alter interactomes frequently. https://t.co/UCK2ODrpId

[Wolf Prize @WolfPrize_]

It is our sincere pleasure to reveal that Professor Benjamin F. Cravatt III of @ScrippsRTI is one of the 2022 #Wolf Prize laureates in Chemistry.

[Rapé Lab @RapeLab]

Excited to present our work on how cells detect the deleterious absence of reactive oxygen species, or reductive stress. Meet a very small #molecularglue for a #ubiquitin ligase and a new regulator of #mitochondria. (1/n)

https://t.co/2XKvvFELUV

[Hojong Yoon @hojong_yoon]

This is legit, out of the world.