@damian_patecki Dobrze wiesz, że najwięcej do powiedzenia o medycynie mają osoby, które nie wiedzą o niej nic. 🤷♂️ Takie czasy, trole internetowe rosną lepiej niż grzyby po deszczu.
4/n #ASCO26 based on NEJM paper
What about OS?
8.8% died in RP+ADT+ARPI group
8.3% died in RP+ADT group
Men over 75yo?
15.2% died in RP+ADT+ARPI group
12.8% died in RP+ADT group
Men under 75yo?
8.0% died in RP+ADT+ARPI group
7.8% died in RP+ADT group
SAEs that occurred during the treatment period and led to death related to tx:
7 of 1050 patients (0.7%) in the apalutamide group and in 1 of 1050 (0.1%) in the placebo group.
As previously discussed ZERO SIGNAL OF OS benefit...potential signal of OS harm.
@neerajaiims@DrChoueiri@PCaParker@NicholasZaorsky@Prof_Nick_James@urotoday@TylerSbrt
Definitely worth reading before we choke on yet another “positive” trial.
I’ll say it once again: let’s escalate diagnostics and use modern tools that allow us to select patients appropriately for treatment escalation!
#ASCO26
Talk about real-time updates. NEJM paper now online and my predictions and inferences appear true.
Majority of MFS events were by PET not conventional imaging. "Most distant metastases were identified by PSMA PET (53.0% of those in the apalutamide group and 60.7% in the placebo group)"
VERY IMPORTANTLY: "No significant between-group difference was observed in metastasis-free survival assessed with conventional imaging alone (hazard ratio, 0.84; 95% CI, 0.67 to 1.07)"
Not only does MFS cross 1, but the HR also crosses the surrogate threshold effect (0.81).
@urotoday@PCF_select@US_FDA
1/7 🧵 New in @LancetOncology: we built a Delphi consensus on primary endpoints for MDT trials in oligometastatic cancer — because the endpoints we've been using were designed for drugs, not for ablation.
On behalf of the EORTC–ESTRO OligoCare consortium.