Ruben Kenny Briceno

Infectious Diseases and Tropical Medicine🇵🇪 MSUCOM & Institute for Global Health researcher🇺🇸

[David Ouyang, MD @David_Ouyang]

I built an interactive echocardiography tutorial with Claude Code.

Chapter 07: a 3D heart, the standard imaging views, the probe position, and simulated ultrasound video.

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

The convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae (hv-CRKP) is an emerging public health threat!
🆕💥🟢Systematic review from Europe
🔺NDM carbapenemase predominate, often linked to hybrid plasmids.
🔺Genotype-phenotype discordance complicates detection and supports enhanced surveillance
🔺hv-CRKP isolates were identified in 14 European countries, with major epidemic clusters reported in Italy and Germany
🔺Diagnosis remains challenging because no single method reliably identifies hv-CRKP
🔺Clinical presentation therefore remains a critical alert signal, particularly in severe or unusually invasive infections
https://t.co/Y4GHBjVzXr

[Eric Topol @EricTopol]

How do cells die? What used to be thought were 2 ways, now it's >20
https://t.co/pRnIaxdll6

[Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 @ABsteward]

Finally it's published!
🆕🔥🟢Systematic Review and Bayesian Meta-Analysis @DrToddLee
What is the association of cefepime with all-cause mortality compared with other β-lactam antibiotics?
This systematic review and bayesian meta-analysis found that cefepime was associated with higher odds of all-cause mortality compared with other β-lactams Meta-analysis of published peer-reviewed RCTs (73 trials, 15 411 patients) showed that cefepime was associated with a 98.6% posterior probability of higher mortality compared with other β-lactams (OR, 1.17; 95% credible interval, 1.02-1.34). Posterior distributions generally favored higher odds of mortality across all comparator β-lactams, across all clinical indications, and with doses of 2 g or more every 12 hours. #idxposts https://t.co/RNML77btb6

[Ekaterina Zaharieva @EZaharievaEU]

🌍 Researchers are choosing Europe!
The 2026 MSCA Postdoctoral Fellowships received a record 21,627 applications from researchers worldwide, backed by €399.05M.

This is #ChooseEuropeForScience in action! https://t.co/dkJvggASrS

[Juan E Losa. Infectólogo. HUFA. URJC. Sandoval Sur @juanelosag]

Creo que, al menos por lo que se refiere a tratamiento antirretroviral, la conferencia mundial de sida de este año 2026 es la de la “pastilla una vez a la semana”. https://t.co/5YbPZ24yQG

[Juan E Losa. Infectólogo. HUFA. URJC. Sandoval Sur @juanelosag]

El ensayo ASTARTÉ demuestra que existen betalactámicos alternativos a los carbapenems para tratar las bacteriemias por enterobacterias productoras de beta-lactamasas de espectro ampliado. https://t.co/XyM8aRPbzs

[Dr sthanu subramanian @drsthanus]

Piperacillin–tazobactam and Hypokalemia.

A patient on piperacillin-tazobactam can develop progressive hypokalemia because the drug acts as a non-reabsorbable anion.

The high sodium load from the penicillin formulation increases distal tubular fluid flow and electronegativity, which drives profound renal potassium wasting that resists standard repletion until the antibiotic is stopped.

The patient is experiencing piperacillin-tazobactam-induced renal potassium wasting, a phenomenon driven by the chemical and pharmacological properties of the antibiotic.

When this occurs, aggressive potassium replacement often fails to normalize serum levels because the kidneys continue to actively excrete the supplementary potassium.

*Associated Clinical Presentation.

Because hydrogen ions (H⁺) are excreted alongside potassium to neutralize the negative electrical charge in the urine, patients with this condition classically develop hypokalemic metabolic alkalosis.

**Clinical Management Steps.

1. Check Magnesium Levels:

Always check and aggressively correct the patient's serum magnesium first.

Concomitant hypomagnesemia opens renal outer medullary potassium (ROMK) channels, allowing unchecked potassium wasting and rendering potassium replacement completely ineffective.

2. Consider Drug Discontinuation:

If the hypokalemia is severe, progressive, or causing ECG changes, discontinue piperacillin-tazobactam.

The tubular dysfunction is completely reversible; once the drug is stopped, serum potassium levels typically normalize rapidly within 24 to 48 hours.

3. Switch Antibiotic Therapy:

Transition the patient to an alternative broad-spectrum agent with a lower risk of renal anion-wasting, such as a carbapenem or cefepime, depending on culture and sensitivity data.

●The diverse pathophysiological mechanisms and system-wide adverse effects associated with drug-induced hypokalemia
https://t.co/gIztXAYRcc

[AbdAllah Othman @CardioBeat_]

https://t.co/TV1Fq7zK3N
🫀⚡ 8 ECG Mnemonics That Make Recognition Easier! From Bird Beak 🐦 to Shark Fin 🦈 and Hockey Stick 🏒—visual memory can make challenging ECG patterns stick. Which one is your favorite? 👇
#ECG #Cardiology #Electrocardiography #MedEd #MedicalEducation

[Juan E Losa. Infectólogo. HUFA. URJC. Sandoval Sur @juanelosag]

Siempre nos queda Paul Sax para resumir las conferencias internacionales de VIH.
https://t.co/biU4CDo2DM

[Alí S. Meza @AliSMV7]

🔺Nontuberculous Mycobacterial Skin and Soft Tissue Infections

https://t.co/et66nAY4ir

[ares. 🎧 @aresotik]

NOTEBOOK LM VA A CAMBIAR CÓMO TRABAJAS

Este tío lo explica todo en un tutorial de 4 horas totalmente gratis.

Desde cero hasta nivel avanzado.
Sin pagar nada.

Guárdalo 🔖

[Juan E Losa. Infectólogo. HUFA. URJC. Sandoval Sur @juanelosag]

En estos días se cumplen 30 años del “efecto Lázaro” en VIH, aquel por el cual gracias a la administración combinada de antirretrovirales las personas enfermas dejaron de fallecer. Coincidiendo con la efeméride, la revista NEJM publicó ayer una revisión sobre este tratamiento.

[Juan E Losa. Infectólogo. HUFA. URJC. Sandoval Sur @juanelosag]

https://t.co/0e3rnxgtlv

[Instituto de Enfermedades Tropicales @iet_untrm]

El INS, el Instituto de Investigación de Enfermedades Tropicales - UNTRM y la DIRESA Amazonas desarrollan un innovador kit molecular para detectar la malaria de manera rápida, precisa y sin necesidad de cadena de frío, facilitando su llegada a comunidades alejadas del Perú🦟🧬🇵🇪

[ACIN Capitulo Central @acincentral]

La neumonía por Pneumocystis jirovecii (PJP) ya no es exclusiva de pacientes con VIH. Su incidencia está aumentando en personas inmunocomprometidas sin VIH, lo que exige mayor sospecha clínica, diagnóstico temprano y estrategias de profilaxis individualizadas. Una excelente revisión sobre los estándares terapéuticos en 2026. #Infectología #PJP #Antimicrobianos #MedicinaIntensiva @Lauranocuab

[Dr. Joshuan J. Barboza @joshuanbarbozam]

He creado un portal de investigación Tau, en donde podrán hacer un Match con las revistas potenciales según su tema de investigación.
contiene a todas las revistas, los APC, tiempos de publicación, H index, cuartil, etc.

https://t.co/f1UTpxNmL1

[Alí S. Meza @AliSMV7]

🔺IDSA/ESCMID 2026 Guidelines on Staphylococcus aureus Bacteremia

https://t.co/i89qCDCiMy

[NEJM @NEJM]

Multiple sclerosis, a common autoimmune disease of the central nervous system, affects the brain, optic nerves, and spinal cord. Its hallmark effects are inflammation, demyelination, and neurodegeneration. 🔗 https://t.co/McH5l7urUG

In traditional descriptions of the disease, the myelin sheaths surrounding nerve-cell axons are the main target; peripheral nerve myelin, although structurally similar, is unaffected.

The disease typically manifests with discrete focal attacks that affect vision, sensation, strength, and balance, and over time the frequency of attacks decreases and progressive worsening with prominent neuronal injury supervenes (seen in figure). In a minority of patients, symptoms are progressive from onset. Diagnosis rests on clinical criteria and magnetic resonance imaging (MRI) findings, supplemented by clonal expansions of immunoglobulin in cerebrospinal fluid and slowing in central nerve conduction velocities as measured by evoked potentials.

Learn more in the Review Article “Advances in Multiple Sclerosis” by Stephen L. Hauser, MD: https://t.co/McH5l7urUG

[Instituto Nacional de Salud @INS_Peru]

🗒️ #NotaDePrensa | 🧠 INS articula la construcción de primer programa nacional de investigación sobre demencias y el envejecimiento en el Perú

▶️ Revisa la nota completa: https://t.co/HRT3UV7dPj

#INS #SaludPerú #Demencias #Investigación #Envejecimiento