Stefan Kotschi

DFG Walter Benjamin Postdoc @ThalesPapaG @nyugrossman MD @LMU_Muenchen @barteltlab

[Stefan Kotschi @s_kotschi]

Happy to share our paper about localized signaling from lung cancer to sensory neurons in cachexia together with Michael Cross and @ThalesPapaG at @nyugrossman!
Thank you to @dfg_public for funding my journey

https://t.co/J9SGd5eIbS

[Alexander Bartelt @BarteltLab]

Here is our new review in Redox Biology on

Ferroptosis in Health and Disease

https://t.co/Hzcy5r9CfC

[Stefan Kotschi @s_kotschi]

Today I say goodbye to @BarteltLab @ipekresearch where I was fortunate to spend the last 3.5 years. I will be eternally grateful for the guidance and good times! Off to new adventures @SohailTavazoie @RockefellerUniv

[Nienke Willemsen (she/her) @nwillemsen95]

Fire up the pyre - inosine as a novel thermogenic signal 🔥Happy to see that our comment on the remarkable work by @labpfeifer is finally out - together with @s_kotschi & @BarteltLab. You can read it now in @sigtrans_sttt: https://t.co/N56mPV19xp

[Stefan Kotschi @s_kotschi]

Looking forward to this Tuesday presenting my work so far in @BarteltLab and a great discussion! Thank you for the invite @jananerahbani! Please all join and subscribe to this great seminar series!

[Vera Pieters, PhD @VeraPieters_]

THIS TUESDAY!
-Adipose Biology Seminar Series-

⏰Tuesday Oct 26, 12pm-1pm EST
🎙️ Dr @HaopengXiao from @echouchani Lab
🎙️@s_kotschi from @BarteltLab
💻Details on poster below
🌱Kindly supported by @MbD_UofT

Please retweet!

[Lyssiotis Lab @LyssiotisLab]

This absolute gem just landed in the lab Slack channel. Thanks @JonAlektiar for the joy; #factchecking from
@BrandonTWChen (DMT1 does not oxidize Fe2+).
Ferroptosis nerds (@bstockwell, @SJD956, @YatrikShahLab, @BoyiGan, @AngeliFriedmann), check it out: https://t.co/vnCBLEeNgO

[Nienke Willemsen (she/her) @nwillemsen95]

We're excited for the last day of #cphbat2022 🔥 this conference is really delivering on the great talks & interesting discussions @_Anna_Jung @s_kotschi

[Molecular Metabolism @MolMetab]

The novel cell-death #ferroptosis remains to be fully understood.

This paper links the NFE2L1-proteasome pathway to ferroptosis and highlights a range of potential clinical implications.
@BarteltLab @LMU_Muenchen @helmholtz_diabc

➡️https://t.co/8Ac7BgkU3T

[Nienke Willemsen (she/her) @nwillemsen95]

Check out this new paper by our outstanding @s_kotschi! NFE2L1-mediated proteasome function protects from ferroptosis 💥 @BarteltLab @MolMetab https://t.co/NfDJWV1u5V

[Stefan Kotschi @s_kotschi]

Read the fruits🫐 of my labor so far @BarteltLab @MolMetab #MD thesis🔬. #ferroptosis blocks proteasomal activity - NFE2L1 comes to the rescue🆘 and helps our #adipocytes survive! Thanks to everyone involved! #proteostasis @Ferroptosis2306 @LMU_Uniklinikum

[Alexander Bartelt @BarteltLab]

Final version @s_kotschi et al. out now @MolMetab - big THX to @nwillemsen95 @Anahita_Ofoghi @Conrad_Lab @HelmholtzMunich @Ferroptosis2306 @dfg_public @ERC_Research #proteostasis
👉NFE2L1-mediated proteasome 🧵function protects from ferroptosis ☠️
https://t.co/0DSLNkXceh

[Stefan Kotschi @s_kotschi]

In my MD I studied oxidative stress in #adipocytes and got interested in #ferroptosis - happy to see our work out there. Thanks to our @Ferroptosis2306 priority program for making this work possible!

[Alexander Bartelt @BarteltLab]

Excited to share our work led by @s_kotschi on the regulation of #ferroptosis by NFE2L1-mediated proteasome function - extremely grateful to @Conrad_Lab @sanathkr_ for their help understanding the link to GPX4 & @dfg_public @Ferroptosis2306 for funding!

https://t.co/7y8F9m7C68

[Alexander Bartelt @BarteltLab]

Hey @CarolinMuley & @s_kotschi your accepted paper is online @FrontEndocrinol - congrats!

Role of ubiquilins in brown adipocyte proteostasis and thermogenesis

https://t.co/ZAmVAi6Fwf

[Alexander Bartelt @BarteltLab]

Just in - manuscript accepted @FrontEndocrinol - very pround of @CarolinMuley and @s_kotschi for pushing this through, thanks to the editor and reviewers for providing critical feedback! More to follow...

[Stefan Kotschi @s_kotschi]

@MatthewDLynes @BarteltLab @FarnazShamsi @phillipwhite14 @GiroudMaude Great point @MatthewDLynes! We should look into big data 💻! But at least on gene expression the neighbouring genes were not changed..

[Stefan Kotschi @s_kotschi]

@FarnazShamsi @phillipwhite14 @BarteltLab Thanks @FarnazShamsi! So AATBC is a intergenic lncRNA and we have not seen any regulation of the neighbouring genes - which we found quite striking since it is exclusively found in the nucleus!

[Phillip J White PhD @phillipwhite14]

Super talk on the LncRNA AATBC in brown fat @BarteltLab. Your data suggest this novel LncRNA has a major impact on the mitochondria, do you know if AATBC is expressed in other metabolic tissues such as skeletal muscle and whether expression is altered in obesity? #METPHYS2021

[Stefan Kotschi @s_kotschi]

@luiz_leiria @BarteltLab @phillipwhite14 @ReviewCommons Thanks Luiz, we found the other way around, that cAMP signaling over various inducers elevates AATBC. RNASeq and other results didn't show us the classic PKA-pathway so we think that the regulation is more specific to mitochondria. But check cAMP-levels is always worth a try!

[Alexander Bartelt @BarteltLab]

Now on @biorxivpreprint 👇

#Obesity-linked lncRNA AATBC regulates adipocyte plasticity by @GiroudMaude & @s_kotschi et al.

Big THX to @helmholtz_diabc @HIMAG_Leipzig @WolfrumLab @soeren1974 @ZeigererLab @CGarciaCaceres @AvHStiftung @ERC_Research @dzhk_germany @dfg_public et al.

[bioRxiv @biorxivpreprint]

The obesity-linked human lncRNA AATBC regulates adipocyte plasticity by stimulating mitochondrial dynamics and respiration https://t.co/43p1WzrIzk #bioRxiv

[Alexander Bartelt @BarteltLab]

JUST published:

HAND2 is a novel #obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling

BIG THX to lead author Dr. Maude Giroud👩‍🔬, our generous collaborators, @AvHStiftung @ERC_Research and the editorial team @DiabetologiaJnl for a fair review