Samuel Corless

[Ben Carty @ben_carty93]

Calling all aspiring centromere biologists! Rae Brown (Straight Lab) and I will co-chair the GRS for Centromere Biology, preceding the main GRC on 27th-28th July 2024. Please retweet and register before April 21st to be considered for a talk! https://t.co/eLVNOsGWPW

[Douglas Vernimmen @DougVer]

Join us at our 22nd @EdinEpigenetics Meeting
@EdinburghUni Network #research #epigenetics #chromatin #Edinburgh

[Edinburgh Cancer Research @EdinCRC]

Warm welcome to our new Principal Investigator Dr Nezha Benabdallah @NsBenab👍! Nezha leads the Chromatin Regulators in Cancer research group. Her scientific interests focus on sarcoma research and chromatin biology. Read more on our website:
https://t.co/L954rZQPxr

[Samuel Corless @sam_corless]

@arnaud_kr @ERC_Research @embl congratulations Arnaud, well deserved!

[Cell Press Sustainability @CellPressSust]

Several roadblocks must be overcome to make molecular biology more sustainable, but @GreenLabGuy @ucl argues that we must treat sustainability like we do health and safety in the lab—as a necessity.

[Cees Dekker @cees_dekker]

a while ago I posed this question...

1/

[Samuel Corless @sam_corless]

Centromere biologists take note!

[Claudio Cantù @ClaudioCantu81]

Improve your CUT&RUNs with
The CUT&RUN Suspect List of problematic regions of the genome
https://t.co/EjprPBD36g
by @AnnaNordin96 w/ @GianlucaZamba @ppagella86
now @GenomeBiology
❗️IMPORTANT: the Suspect Lists content did not change from the previous release @biorxivpreprint

[Samuel Corless @sam_corless]

@TismaMilos @LipfertLab @cees_dekker wow, that's great!

[Samuel Corless @sam_corless]

This study is amazing! I always wondered if the role of nucleosomes was more about DNA supercoils than 'packaging', these different topologies are a nice hint in that direction. https://t.co/d2ixopyK3l

[Samuel Corless @sam_corless]

Did you know JQ1 directly targets BRD4 at centromeres? #Epigenetics is more than gene regulation! To find out more read our updated BioRxiv https://t.co/p12HpSL0SV

[Samuel Corless @sam_corless]

@pablonavarroLAB oh wow, this data is beautiful!

[bioRxiv @biorxivpreprint]

The bromodomain inhibitor JQ1 is a molecular glue targeting centromeres https://t.co/CIDnxbfMl1 #bioRxiv

[Samuel Corless @sam_corless]

Thanks chromatin community! We’ve been digging around in your repetitive DNA (>40,000 ChIP-seq samples) and have discovered a totally unexpected role for BRD4 and JQ1 at centromeres. Very happy to share our preprint. https://t.co/9P1NVWObqt

[Science Magazine @ScienceMagazine]

New research in Science presents a synapse-by-synapse map of an insect’s brain, representing a valuable resource for future experimental and theoretical studies of neural circuits and brain function. https://t.co/VFjsY2f9aU

[Cees Dekker @cees_dekker]

Biophysics question:

In transcription, RNApol generates positive supercoils ahead of it and negative ones behind it

WHY?

Why doesn’t RNApol instead simply track 1 strand of the duplex, follow its helical twist along the duplex, and thus rotate without any supercoil generation?

[Samuel Corless @sam_corless]

@cees_dekker could this instead be an evolutionary question? If RNA polymerase originally evolved to replicate RNA, perhaps the supercoil problem resulting from dsDNA was solved by evolving mechanisms to cope with (and then exploit) this phenomenon? https://t.co/xcadeyjTbS

[Nick Gilbert's Lab @chromatinlab]

Check out our newest review paper!

[Maiko Kitaoka 北岡舞子, PhD @MaikoKitaoka]

2018 and 2020 GRS Centromere Biology Chairs! #GRCentromere @BuryLeah @SmithOwenK @sam_corless