Our original paper in Cell showed that a subset of solid tumors produce retinoic acid to hijack monocyte differentiation and evade anti-tumor immunity. https://t.co/rSeyYZxnP7 @CellCellPress
A recent study of mouse models and human sarcoma tissue implicates retinoic acid, produced by the tumor cells of sarcomas, in blunting antitumor immune mechanisms.