Samriti Arora

MD Pathology

[Yavuz Sahin, MD @mdyavuzs]

Giant Cell Tumors in one page: Histology, IHC & Molecular Pearls

[Charlie Herndon @DrCycloPath]

✅ Lymphomatoid Granulomatosis 🎯🫁
• Angiodestructive polymorphous infiltrate with geographic necrosis
• Driven by EBV-infected B cells in a background of reactive T cells
• Graded (1-3) based on the absolute density of large atypical cells
• Despite the name, well-formed granulomas are characteristically absent

[Charlie Herndon @DrCycloPath]

#PathQuiz 🔬🫁 #ThoracicPath

A) Mucoepidermoid Carcinoma
B) Papillary Adenocarcinoma
C) Sclerosing Pneumocytoma
D) Papillary Adenoma

#Pathology
Clue in caption 🧐

[Charlie Herndon @DrCycloPath]

#PathQuiz 🔬🦋 #EndoPath

A) Secretory carcinoma
B) Hyalinizing trabecular tumor
C) Papillary thyroid carcinoma
D) Cribriform morular thyroid carcinoma

#Pathology #ThyroidPath Clue in caption 🧐

[Charlie Herndon @DrCycloPath]

#PathQuiz 🔬
🧠 #NeuroPath #PediPath

A) Pilocytic astrocytoma
B) Medulloblastoma
C) Myxoid glioneuronal tumor
D) Diffuse leptomeningeal glioneuronal tumor

#Pathology #MolecularPath
Clue in caption 🧐
@IARCWHO

[Charlie Herndon @DrCycloPath]

#PathQuiz 🔬
A) Hyperplasia without atypia
B) Hyperplasia with atypia
C) Endometrial polyp
D) Atypical polypoid adenomyoma

#Pathology #GYNPath #Endometrium
Clue in caption 🧐

[Charlie Herndon @DrCycloPath]

#PathQuiz 🔬 #GYNPath
A) Low-grade serous carcinoma
B) Wolffian tumor
C) High-grade serous carcinoma
D) Mesonephric-like adenocarcinoma

#Pathology Clue in caption 🧐

[Anupama Arya @AnupamaArya12]

50/F Pap smear #cytopath #pathtwitter #pathresidents

[Charlie Herndon @DrCycloPath]

💉🔬 #CytoQuiz
🫁
A) Adenocarcinoma
B) Squamous Cell Carcinoma
C) Small Cell Carcinoma
D) Neuroendocrine Tumor
#CytoPath #Pathology

[Janira Navarro @Janiranavarro]

Patchy moderate chronic active colitis

Dr. Krasinskas recomendation for this case:
- If I receive some fragments of colonic mucosa showing chronic active colitis, and others that appear "normal", I use the term "patchy," as in this case.

On initial presentation, IBD/UC tends to be diffuse and involves the rectum, distal colorectum or the entire colon (pancolitis).
Uninvolved "skip" lesions are uncommon in untreated UC but can be seen in treated UC and in segmental colitis associated diverticulosis (SCAD)

This patient had diverticulosis, making the histologic findings c/w SCAD

Dr. Krasinskas - Tips and Hints in Surgical Pathology, Thoracic pathology #USCAP #pathology #PathX

[Charlie Herndon @DrCycloPath]

Answer for #2: Atypical endocervical cells
Cells: sheets, strips, pseudostratified
Nuclei: enlarged, elongated, hyperchromatic with heterogeneous & coarse chromatin
Hyperchromasia that is more monotonous than simple metaplasia
Cytoplasm: may be abundant, but N:C is increased; distinct cell borders
#CytoPath #PathSky #PathTwitter #Pathology

[UPMC Pathology Residency Program @UPMCPath]

AP case of the month: Woman in her 6th decade with progressive gait issues & paresthesia. MRI showed an enhancing intradural extramedullary thoracic spinal cord mass. Previously resected and recurred after 3 yrs. Histology: pleomorphic cells, EMA+, vimentin+, Ki-67 ~20–25%.

[Sam Khader, MD @SamKhader]

#Cytopathology is always helpful!
A squash prep during a frozen section for a neurological tumor. Pleomorphic cells with cytoplasmic extensions, suggestive of a high grade astrocytoma. IHC is +ve for GFAP. NGS is +ve for IDH1 mutation. The final Dx is glioblastoma. @SaeedAsiry

[AANP @neuropathology]

Diffuse astrocytoma, MYB or MYBL1-altered. An infiltrating, but grade 1 glioma! (Note the trapped neurons—evidence of infiltration) Tumor cells rel. monomorphic, round to ovoid or spindly. It is strongly associated with epilepsy. #neuropath #neuropathology #pathx #PathTwitter

[Elizabeth Montgomery, MD @LizMontgomeryMD]

Such a perfect example of hepatic focal nodular hyperplasia with the classic "map-like" glutamine synthetase immunohistochemical staining pattern. Note that the adjoining normal liver tissue lacks that pattern. #UMiamiPath

[Siba El Hussein, MD @SibaElHussein]

(1/5) Key points from today's amazing lecture by @ljmedeirosMD :

Major mutations in pathways involved in DLBCL+ potential targets that can be assessed by IHC, summarized in the pics below

#hemepath #hemepathmda #virtualpath #virtualhemepathmda

@KirillLyapichev @MDAndersonNews

[Mireille Bitar, M.D. @bitar_mireille]

Posterior fossa 4th ventricular brain mass in a young patient, what molecular alterations are likely detected in this lesion? 🤔
#pedipath #neuropath #pathology

[Pathology mcqs @Pathology_mcqs]

💥 LEIOMYOSARCOMA simplified!
WHO 2022 👉 Spindle, Epithelioid & Myxoid types with key histologic clues 🔬
🎉 Don’t miss the Pathology Day 2025 offer — 20% OFF on WHO-based modules! 🧠
#PathologyMCQ #WHO2022 #Leiomyosarcoma #PathologyDay

[Craig Horbinski @CraigHorbinski]

This might LOOK like unremarkable cortex, but an IDH1 R132H immunostain highlights a few scattered oligodendroglioma cells lurking in the background. Tricksy!!! #pathology #neuropath #PathTwitter

[Craig Horbinski @CraigHorbinski]

Desmoplastic infantile ganglioglioma, WHO grade 1. Those are some really big ganglion cells!
#pathology #pathtwitter #neuropath #pediatrics