Samuel Moix

[Samuel Moix @SamuelMoix]

Hi #ASHG2025, the Lausanne team made it to Boston ! Excited to present our latest discoveries — come say hi and learn more about our research!
@ClaraDPailler, @Leona_Knusel, @dianazanoaga, @Rbn_Hfmstr, @A_van_der_graaf, @CavinatoTheo, @dbc_unil

[Robin Hofmeister @Rbn_Hfmstr]

🚨 New preprint out!
We reconstructed parental haplotypes in >440k individuals (UK & Estonian biobanks) to estimate assortative mating directly in the parental generation.
This reveals intensified assortment in recent generations.
🔗https://t.co/wnag6TiWWo

[Robin Hofmeister @Rbn_Hfmstr]

🚨 Our parent-of-origin study is out in @Nature ! 🧬
Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss.
🔗https://t.co/OWW6vGxGYI

Highlights below!

[Tabea Schoeler @TabeaSchoeler]

🚨New preprint is out!
How do genetic effects on complex traits change with age?

In this work, we compare different approaches to obtain age-varying genetic effects, and show how design and modeling choices can impact the conclusions we draw.
https://t.co/XUK6PLkx12
A thread 🧵

[Adriaan @A_van_der_graaf]

Our paper, MR-link-2 has just been published! Offering pleiotropy robust Mendelian randomization from a single region! https://t.co/RvzjwOFPBC

[Zoltán Kutalik @zkutalik]

Extremely proud of @Rbn_Hfmstr for his @eshgsociety Early Career Award received yesterday in Milan. A richly deserved recognition of his outstanding presentation and ingenious research on parent-of-origin effect inference! #ESHG2025

[Robin Hofmeister @Rbn_Hfmstr]

🎉 Hi #ESHG2025, the Statistical Genetics Group and alumni (@zkutalik ) is coming in force!

Check out our latest work on human genetics!

📍Come see our talks & posters, or reach out to meet us!
@CAuwerx @dianazanoaga @SamuelMoix @A_van_der_graaf @CavinatoTheo @dbc_unil

[Tabea Schoeler @TabeaSchoeler]

Happy to share our new study on genetic & environmental contributors to age-related decline in ~100K UK Biobank participants! @NatureComms

Here, we used simulation work + longitudinal GWAS to explore risks involved in cognitive/physical decline
(1/)🧵🧵
https://t.co/IYHDyDdz8w

[Robin Hofmeister @Rbn_Hfmstr]

🚨 Preprint update!
We expanded our study on parent-of-origin effects with new findings from the MoBa cohort, now leveraging up to 265,000 individuals!

Discover fresh insights into the genetic architecture of early growth!

Updated preprint: https://t.co/7NoVI2r9PY

[Sina Majidian @SinaMajidian]

FastOMA is out now in Nature Methods 🎉: https://t.co/6nNVfbCVqr A new orthology inference algorithm that scales linearly and is highly accurate. FastOMA can process all >2000 eukaryotic UniProt ref proteomes <24 hours 🚀. Try it out at https://t.co/QUPiRx33J9

[Tabea Schoeler @TabeaSchoeler]

Just out in @NatureHumBehav
👇🏼👇🏼
We focused on the causes & impact of self-report error in the UK Biobank. We found that reporting error does not occur at random, is not independent of other participation behaviours, and can complicate the interpretation of genome-wide findings

[Robin Hofmeister @Rbn_Hfmstr]

🚨 Our preprint on parent-of-origin effects (POEs) is out!

With our new method, we inferred the parental origin of >220,000 individuals, revealing new insights into the genetic architecture of complex traits.

👉 Read here: https://t.co/dm4limMAqM

👇 Highlights below!

[Margaux Hujoel @HujoelM]

Excited to share our recent work: expansions and contractions of DNA repeats have produced many genetic polymorphisms. We studied repeat instability among >700,000 biobank participants using new computational approaches to analyze DNA sequencing data. https://t.co/holxhkoWhI

[Robin Hofmeister @Rbn_Hfmstr]

Hello #ASHG24! Curious about how we can determine the parental origin of both transmitted and untransmitted alleles? Come check out my poster 4137 this afternoon!

[Samuel Moix @SamuelMoix]

Thrilled to be presenting at the Pharmacogenomics session at #ASHG24 today at 11am! Stop by if you're curious about exploring causal relationships between drugs, diseases, and proteins. See you there!

[Robin Hofmeister @Rbn_Hfmstr]

Just landed in Denver for #ASHG24 with the @zkutalik team (@A_van_der_graaf @SamuelMoix ) ! If you’re attending, don’t miss our group’s new research at poster boards 4137F and 4095T, and during a platform talk in the pharmacogenomics session on Friday at 11am.

[UNIL Quantitative Biology PhD program @unil_qb]

Call for PhD in quantitative Biology!!
Applications open ...

https://t.co/QpTubDnSoA

#PhD #computationbiology #quantititivebiology

[nature @Nature]

Genome analysis adds to mounting evidence against the idea that Rapa Nui’s population collapsed owing to overexploitation of natural resources https://t.co/eBOBpvDZCK

[TimePie (focus on anti-aging science) @TimePieChina]

Breaking down causes, consequences, and mediating effects of #telomere length variation on human health @GenomeBiology 🧬🧬

Thanks to @ Samuel Moix @zkutalik @CAuwerx et al.
https://t.co/t0VJsdD9Tu

[Samuel Moix @SamuelMoix]

Here's the final schematic representation of the study workflow. For more details, check out the paper! 📃 Big thanks to @smarie_smarie, @zkutalik, and @CAuwerx for their efforts and work in getting this published, and gratitude to the entire #SGG team.

[Samuel Moix @SamuelMoix]

Thrilled to share my first paper as first author on telomere biology, now published in @GenomeBiology: https://t.co/SFY16vWG1T

Following reviewer feedback, the manuscript now includes extensive sensitivity analyses and replication with independent telomere length data 🧬