#AACR25 Come check out abstract #4516 to see how Bayesian imputation improves survival modeling in NDMM. Our findings suggest PET/CT at diagnosis has strong prognostic value—despite missing data. Don’t miss it :) 🧬
CRISPR came from yogurt bacteria. GLP-1s came from Gila monster venom. Taq polymerase came from hot spring bacteria.
As much as we like to think that progress in biotech is driven by human design, our biggest breakthroughs over the years have all originated from nature.
Just out in the Journal of Clinical Oncology! @JCO_ASCO
A paradigm changing paper on MGUS and Smoldering Myeloma @FrancescoMaura4
And it’s Open Access!!
https://t.co/svHThmjiCm
KEY FINDINGS:
1) We identify for the first time myeloma defining genomic events to differentiate biologic premalignancy (genomic MGUS) from biologic malignancy (genomic Myeloma).
2) We find that most of smoldering myeloma and almost all of high risk smoldering myeloma is biologic malignancy with genomic features indistinguishable from active myeloma
3) We show that some myeloma defining genomic events are also associated with high risk of progression resulting in a genomic model of risk stratification of Smoldering Myeloma.
4) We show that combining the genomic model (genomics) with the IMWG2020 model (clone size) provides a better risk stratification than either alone.
5) We provide the code and information where if you have access to sequencing you can run this yourself to determine whether the patient has genomic MGUS or genomic Myeloma
This is a major collaborative international effort with top centers and researchers pooling data so we can finally address these important questions. @FrancescoMaura4@szusmani@Leif_Bergsagel@myelomaMD@DrOlaLandgren@DrKrinaPatel@Myeloma_Doc@Rfonsi1@DrGarethMorgan1@MSKCancerCenter@MayoClinic@SylvesterCancer@Perlmutter_CC and more.
#MiguelUribe| “Esta guerra tiene culpables y responsables, lo sabemos. No tenemos ninguna duda de dónde viene la violencia, no tenemos duda de quién la promueve, no tenemos duda quién la permite”, aseguró el padre del precandidato presidencial.
https://t.co/R0kxQZ2KMp