Our work describing human transcription-DNA repair coupling in five ❄️EM structures is out @Nature. 🧬🥳
The centrepiece of coupling is the alternative transcription elongation complex that can ubiquitylate lesion-arrested Pol II and initiate DNA repair.
https://t.co/qzHlgXntqa
U2 snRNP is required for efficient Pol II pause release and RNA synthesis in human cells! If you haven't done yet 😉, check the paper here: https://t.co/Yzjmpt0hPo
Open PhD position in my lab at @uniGoettingen and @mpi_bpc ! Come join us if you want to use ultracool electron microscopes🔬and lots of other fun methods to study the molecular biology of mitochondria! 🧬RT appreciated!
https://t.co/Mq2EJjVYSn
🥳 congrats!! 🎊 check out the new story by @Kat_ja_Li, @CramerLab, @lidschreiber providing a resource of transcribed enhancers in 14 human cancer cell lines
I am thrilled to share the new EP of my band RBF:
Curious about how scientist might sound?
Please check us out here:
Stream now on Spotify: https://t.co/LxZZDPUmYN
Instagram: https://t.co/gTO1Tbwny0
The Biotech Paradox of 2020: A Year In Review
The striking dichotomy of simultaneously experiencing agonizing tragedy alongside buoyant optimism.
Surprisingly, in many ways 2020 was actually the best year ever for biotech.
https://t.co/IPH4NNKIHr
Our structures of nucleosome-bound Yamanaka factor Sox2 and Sox11 elucidate how pioneer factors invade chromatin for differentiation and development.
https://t.co/ypkUInxsGu
We are so excited about the just published paper from @MeineckeLab together with Alex Stein (@mpi_bpc). Congrats @VedranVasic and Niels, we are very proud of your amazing work!!!
https://t.co/ogH0LGEGLG
#EESOmics@birdumbrella from @CramerLab: Native RNA identification by #nano-ID allows analyses at the RNA isoform level. Very interesting results about differential RNA isoform stability & its regulation
Our MERLoT manuscript is finally published at
@NAR_Open!! It was my transition work from protein structures to transcriptomics while being an
@EMBOFellows! A huge challenge and great work at the Soeding Lab with Niko (@galicae) and a whole amazing team! https://t.co/2TNEHGzloE
We show directly that transcription activation often involves a decrease in Pol II pause duration. Multiomics reveals this requires CDK9 and increases the productive initiation frequency. In contrast to promoters, enhancers are generally not pause-limited. https://t.co/RcJGLGHTTC