Jeremy Schmit

Emergent behavior in biomolecules. I study how biomolecules interact. Not just 1 or 2 molecules, but moles of them.

[Jeremy Schmit @SchmitBiophys]

In these days without conferences, we need to find new ways to communicate our science. I'm not going to say that I know the right or wrong way to do this. But the right way is with Lego. @Afarnti @PNASNews

[Jeremy Schmit @SchmitBiophys]

Thrilled to be a part of this collaboration!

[Kresten Lindorff-Larsen @LindorffLarsen]

How do proteins mis-fold?

New preprint led by @JAunstrup from @alexander_buell @biophysics_dtu group with MD simulations by Abigail Barclay. We combined experimental measurements of Φ-values with restrained simulations to study the TSE for fibril growth

https://t.co/qKMFunFaUI

[Castaneda Lab @Castaneda_lab]

Congrats to the lab and collaborator @SchmitBiophys ! (more soon!) Polyubiquitin ligand-induced phase transitions are optimized by spacing between ubiquitin units | PNAS https://t.co/Xe6grZAORW

[JCIM & JCTC Journals @JCIM_JCTC]

Circuit Topology Approach for the Comparative Analysis of Intrinsically Disordered Proteins #IDP #compchem #cheminformatics
https://t.co/xEZfNnT8R0
@VSheikhhasani @laurenswh @SchmitBiophys @AlirezaMashaghi
Vol63 Issue8 #JCIM #Bioinformatics

[Pernilla Wittung @PernillaWittung]

Fun collaboration with @SchmitBiophys - I learnt a lot in process and our discovery opens the door for many more experiments!

[Castaneda Lab @Castaneda_lab]

Interested in designing ligands to optimize phase separation of scaffolds in condensates? With @SchmitBiophys, we dived into this problem using designed tetraubiquitin ligand hubs, and combined theory and experiment to uncover molecular rules - learn more: https://t.co/6w2ALyFjhN

[Jeremy Schmit @SchmitBiophys]

@ruthhook_ More like Robin Hood, tbh, although I see how you had to claim the eponym.

[Andrea Bauerfeind @mages05]

Missed The @FASEBorg Nuclear Bodies Conference this year? Read the Meeting Report in the FASEB Journal https://t.co/Q1uxxsdUTo; then sign up to be notified of the next conference, https://t.co/yqY0dNP368.

#NBSRC22 #GeneControl #RNAmetabolism #PhaseSeparation #Genomics #Cancer

[Jeremy Schmit @SchmitBiophys]

That submission feeling...

[Jeremy Schmit @SchmitBiophys]

Thanks to @OASaleh and Fyl Pincus for a great visit to UCSB. And to all the physics and BMSE students for their fantastic questions. It's amazing how much the place has grown since I was there!

[Jeremy Schmit @SchmitBiophys]

Afternoon fun at the Protein Folding #GRC with Ed O'Brian, @fried_lab, and @SulkowskaL. Not shown: @davethirum

[Jeremy Schmit @SchmitBiophys]

Getting an early start on #GRC Protein Folding Dynamics. Looking forward to seeing everyone in Ventura!

[Jeremy Schmit @SchmitBiophys]

@RangachariL Soon (hopefully)! As soon as I get the file from @IDPseminars I'll post it.

[Jeremy Schmit @SchmitBiophys]

Thanks so much for the opportunity to speak!

[IDPseminars @IDPseminars]

@SchmitBiophys showed how the network structure encode the functional properties of condensate to give unique structure/function properties.

He also reminded us that about the limitations of condensates as reaction crucibles: Slow diffusion. ⬇️

https://t.co/Q6lbaCIdv5

[Jeremy Schmit @SchmitBiophys]

Honored and excited to present in @IDPseminars this week!

[IDPseminars @IDPseminars]

Join us on Thursday for seminars by @ioana_ilie_UvA and @SchmitBiophys!

New attendees can register at: https://t.co/RvH67dyQwG

[Jeremy Schmit @SchmitBiophys]

@DavidWSanders2 A common thread in some of my best papers is that I look back and marvel at how naive I was. I'm not sure I would have attempted them if I knew what I know now.

[Jie Xiao @JieXiao_Lab]

Assistant professors wanted! Come to join us at Johns Hopkins School of Medicine Biophysics! https://t.co/6TWnS9H7zy

[Jeremy Schmit @SchmitBiophys]

@alain_andre @SpruijtLab @OodlesOfYewdall @KnowlesLabCamb came to the same conclusion with poly-A condensates. Interesting that you are seeing it more on the NPM1 side than with the RNA.

[IDPseminars @IDPseminars]

After a brief break, we are happy to announce our program for the coming months featuring:
@BoeynaemsSteven, @DrJoanShea @ioana_ilie_UvA, @SchmitBiophys, @savitski_lab, @Nicolas_Fawzi, @daviddesancho, Frans Mulder, @jrkumita and Christine Keating.

[Jeremy Schmit @SchmitBiophys]

Special thanks to lead author @PhanBioPhys for doing all the hard work and @HalfmannLab for helpful discussions. 9/9

[Jeremy Schmit @SchmitBiophys]

Announcing the latest from the Schmit group: a special treat for the amyloid afficionados in the Twitterverse (I know you're out there!) A look at nucleation of the aggregates driving diseases like Alzheimer’s and Huntington’s. 1/9
https://t.co/auEWj13eqF

[Jeremy Schmit @SchmitBiophys]

Our result explains co-aggregation data in length variants. Since amyloid nuclei only involve a few amino acids from each chain, they are relatively insensitive to sequence or length differences. Differences are more important during elongation. 8/9
https://t.co/0Pm8eGaBE3