Castaneda Lab

We use molecular biophysics, cell biology, and structural biology to study protein quality control mechanisms in ALS and other disorders @SyracuseU.

[Castaneda Lab @Castaneda_lab]

Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate:
https://t.co/d7W77odNPv
New publication with Dan Kraut's lab at Villanova where we look at proteasome and deubiquitinase recruitment and activity in UBQLN2 condensates!

[Castaneda Lab @Castaneda_lab]

Welcome aboard @shaharsu ! So excited to have you here and forge new scientific directions!

[Syracuse University College of Arts & Sciences @SUArtSciences]

Say hello to the new professors joining A&S this fall 👋

➡️ https://t.co/4kZBy5NaNy

[Castaneda Lab @Castaneda_lab]

Super grateful to our lab and our fantastic collaborator Dan Kraut and his wonderful team!

[Castaneda Lab @Castaneda_lab]

Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate:
https://t.co/d7W77odNPv
New publication with Dan Kraut's lab at Villanova where we look at proteasome and deubiquitinase recruitment and activity in UBQLN2 condensates!

[Castaneda Lab @Castaneda_lab]

And promiscuous deubiquitinases (DUBs) can exhibit linkage-dependent activities in the presence of UBQLN2-polyUb condensates (e.g., K63-Ub4 is protected from DUB activity - black curves below)

[Elias Adriaenssens @EliasAdriaensse]

Super happy to see the final version of our paper on the role of NAP1/SINTBAD in PINK1/Parkin mitophagy!

@NatureSMB

Read the full paper here: https://t.co/hCIaVNR6kg

[Castaneda Lab @Castaneda_lab]

Super excited to have you as one of our Biology colleagues @SUArtSciences ! Go #IDPs! Looking forward to all the cool ideas that come out of your lab integrating IDP biophysics and plant biology! Welcome aboard!

[Heather Meyer @Dr_Heatherini]

I am thrilled to announce that I will be joining the Biology Department at Syracuse University as an Assistant Professor in 2025!

[Castaneda Lab @Castaneda_lab]

Super excited to have you as one of our colleagues @SUChemistry @SUArtSciences ! Welcome aboard! I second everything you've written in your thread. We will do our best to help drive your awesome science and collaborations! #IDPs

[Shahar Sukenik @shaharsu]

I'm excited to announce that our lab is moving to @SyracuseU!! We will continue our exploration of how (disordered) proteins sense and respond to changes in their environment, and 📢HIRING AT ALL LEVELS. Get in touch if you're interested! Some details on this move below: 1/5

[Heidi Hehnly-Chang @LovelessRadio]

We had a blast helping out @PattesonLab with #localizationmicroscopy and #zeissAiryscan in @Castaneda_lab and @SU_BioImaging. Paper looks great! https://t.co/yagCObcO4p

[Castaneda Lab @Castaneda_lab]

@BanerjeeLab_UB You are an amazing host @BanerjeeLab_UB !!! Fantastic visit. You are doing amazing science and I feel very lucky to start a collaboration with you and your lab! To 2024 and beyond!!

[Lucia Strader @LabStrader]

My lab jokes that IAA does not stand for 'indole-3-acetic acid', but rather for 'involved in almost anything'. Here is a recent review from us on connections between auxin and abiotic stress.
https://t.co/dT15Bz7T3E

[Castaneda Lab @Castaneda_lab]

Grateful to @SUBiology colleagues like @LovelessRadio for getting us into microscopy and cell work many years ago!

[Castaneda Lab @Castaneda_lab]

#cellbio2023 ASCB attendees - interested in #UBQLN2 #condensates and their roles in cell stress response? Visit Anitha's poster on Sun 12/3 (P1589) to hear about heat stress in cells, while Billy presents on UBQLN2 puncta formation with the @oniHQ nanoimager (P1594)!

[Castaneda Lab @Castaneda_lab]

Recruiting #PhD Bio students to @SUBiology ! If you're at @ABRCMS , come talk to current grad Savannah from @sarah_hall02 lab, and undergrad Alana from @YazBraimah lab! @drhougs has all the info - learn about @SUBioInspired , Neuroscience & our growing dept! (apply by 1/4/24)

[Alex Holehouse @alexholehouse]

Interested in understanding how and why IDRs matter for cellular function?

@BBKrage and I took a deep dive into this question and – with excellent feedback and critiques from colleagues & our amazing editor – put together our perspective on this: https://t.co/kmaC3Zhp3R

[Kohler Proteostasis Lab @VKohler_Lab]

Please RT!

🔬Join the #KohlerProteostasisLab!
We have a fantastic opportunity for a #PhD position in #MedicalScience!

🎯Our goal: Uncovering the #MolecularProcesses behind age-related #Diseases, with a special focus on #Proteostasis during #Ageing

🔍 Interested? Read more =>

[Nicolas Lux Fawzi @Nicolas_Fawzi]

NMR of glutamine-rich prion-like domains in a condensed phase - new stuff from Sandy Wang and @TongyinZ . Structure and position-specific interactions of prion-like domains in transcription factor Efg1 phase separation https://t.co/Ewp4WLEmpX

[Castaneda Lab @Castaneda_lab]

@SUBiology will be at @ABRCMS next week to represent our #PhD program! Amazing lineup attending: @drhougs himself, grad student Savannah from @sarah_hall02 lab, and undergrad Alana from @YazBraimah lab will be there! More soon!