Halfmann Lab

The Halfmann Lab explores the cellular and evolutionary implications of protein self-assembly.

[Halfmann Lab @HalfmannLab]

"Set Phasers to Kill." Derek Lowe's take on our @eLife paper on phase change batteries and cell death is as accurate as it is engaging. Impressed and grateful for the coverage @ScienceMagazine! https://t.co/9ygBill14w

[Halfmann Lab @HalfmannLab]

Also, check us out on https://t.co/029WCdfHmT front page! Congrats again @arg_arginine. Thanks to pioneering structural biology of death domains (DFDs) from @WuLabHarvard and previous collab with Zhijian 'James' Chen @UTSWMedCenter that led us to the protein batteries concept.

[Stowers Institute @ScienceStowers]

Why would a healthy cell decide to die? Investigator @HalfmannLab joined @NPR's @npratc with @NPRjonhamilton to discuss his #research on how and why cells decide to self-destruct—a process known as programmed cell death.

🎧 Listen here: https://t.co/PF9WcptMyC

[Halfmann Lab @HalfmannLab]

@arg_arginine @ScienceStowers YOUR work, Alex! After years of effort and teasing apart what we've actually uncovered here, I'm so glad we can finally plant our flag on this discovery. Excited to see if other proteins function like batteries.

[Stowers Institute @ScienceStowers]

Alex Von Schulze, postdoc in the @HalfmannLab, is exploring how proteins clump together to form disease-linked amyloids, and why collaboration is the key to scientific discovery. 🧠 #neuroscience

Learn more in this #PostdocProfile Q&A: https://t.co/lRmRHYot1a

[Halfmann Lab @HalfmannLab]

MD simulations let you watch a microsecond or so of one protein's life in a box. But in the cell thousands of proteins work together, over much longer timescales. With @IlyaVakser's group and their new simulation method, GCell, we're now beginning to see this emergent behavior!

[Amar Singh @DrSinghAmar]

Delighted to share #MyACSCover and our recent study, "Highly Optimized Simulation of Atomic Resolution Cell-Like Protein Environment", published by @ACSPublications in J of Phys Chem B.

Congratulations to Prof. @IlyaVakser , @HalfmannLab , and the team!
https://t.co/1p5i033hQ0

[Roy Kishony @RoyKishony]

1/n Can LLMs perform scientific research? And, can they do so while enhancing key scientific values including transparency, traceability & verifiability? Check out our preprint on the "data-to-paper" platform. w the amazing @TalIfargan @LostInTranscrip https://t.co/60Go3TR5tn

[Stowers Grad School @StowersGrad]

Meet a #StowersGrad faculty member! Randal Halfmann (@HalfmannLab) seeks to understand #aging, the inexorable decline in cellular and bodily function that results from the unidirectional nature of self-assembly by supersaturated proteins. #PhD

Learn more: https://t.co/rziz5Q3wEg

[Halfmann Lab @HalfmannLab]

Kudos also to a responsive editorial staff, who offered to provide Senior Editorial oversight in the second round of review. I feel empowered to refocus on science rather than academic politics – this feels like the future of science publishing. @ASAPbio_

[Halfmann Lab @HalfmannLab]

Thank you, @eLife, for transparent review!

Exercising the power to publicly address a reviewer’s untenable position changed the outcome for our latest paper, the findings of which are recognized as “fundamental” by eLife’s updated assessment.
https://t.co/kWXvbJlIKy

[Halfmann Lab @HalfmannLab]

Great job Justin! Now we just need the yeast to write their own paper. #CRC23

[Vidyanand Sasidharan @Vidyanandsasi]

one poster, 8 hands to hang it. #CRC2023 kicks off and everyone is excited to share their scientific discoveries with their peers. Great job @StowersXroads for organizing such a wonderful event @ScienceStowers. Shriram @HalfmannLab amazing presentation#researchtalks #scievents

[Halfmann Lab @HalfmannLab]

Yes, science is FUN! (even for the nerds sitting in the corner with a calculator ;) Kate, thanks for helping make science accessible to everyone!

[Stowers Institute @ScienceStowers]

#ICYMI: Today @HalfmannLab and @K8theChemist joined @adavalostv on @GreatDayKC to talk all things #STEMeducation and @seekingascipod, our #podcast with @kcur. 🎙️ @fox4kc

📺 Watch here: https://t.co/rifwxeKCji

[Halfmann Lab @HalfmannLab]

@ScienceStowers @stevekraske @KCURUpToDate FWIW, Steve is as cool in person as he sounds on air.

[Halfmann Lab @HalfmannLab]

@SaelicesL @Hlashuel Echoing Lorena- Hilal, your keynote on night 1 beautifully set the scene for the rest of the conference. Thank you so much! Looking forward to 2025.

[Halfmann Lab @HalfmannLab]

Still unpacking my supersaturated brain after a fantastic #PACSRC FASEB protein aggregation conference. Thanks to all the speakers and attendees for making this so worth while! And BIG thanks again to our sponsors! #amyloid

[Halfmann Lab @HalfmannLab]

@p_vanderwel @JoachimiakL @SaelicesL Thanks so much, Patrick! It was great to catch up and talk polyQ!

[Halfmann Lab @HalfmannLab]

Ron is a pioneer on the mechanism of polyQ aggregation, and an inspiration to me. It was a nice surprise that our new in-cell method validated his twenty year-old model derived from rigorous test tube experiments. Good science stands the test of time!

[Stowers Institute @ScienceStowers]

#ICYMI: New #research from the @HalfmannLab revealing the start of #Huntingtons disease published in @eLife. Here is what Ron Wetzel, PhD, @PittTweet @UPMC, had to say about the findings.

Read more: https://t.co/Kq9FnZNQTG

#ScienceTwitter #Discovery

[Halfmann Lab @HalfmannLab]

Proud moment in the life of an academic -- first @StowersGrad PhD student from my lab. @arg_arginine - you set a high bar!

[Halfmann Lab @HalfmannLab]

Link to the primary paper: https://t.co/gKPoIP4pBX

[Halfmann Lab @HalfmannLab]

Now out in eLife – our epic journey into the heart of polyQ to deduce the structure of an amyloid nucleus. Spoiler: it’s not #LLPS. Even more surprising, oligomerization blocks nucleation!

[Stowers Institute @ScienceStowers]

“One of the big mysteries of #Huntingtons, #Alzheimer’s, and #ALS is why disease coincides with amyloid, yet the amyloids themselves are not the main culprits.” @HalfmannLab discusses new #research published in @eLife.

Read here: https://t.co/Qj60njRfXM

#ScienceTwitter