scnac2022

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest paper on the synthesis of base-modified RNA using engineered DNA polymerases published in @NatureComms. Enables construction of hypermodified RNA bearing bulky modifications or site-specifically modified RNA (1). https://t.co/IFlzsXH1yF @IOCBPrague @science_charles

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest paper on synthesis of novel benzofuro-fused deazapurine nucleosides just published in @EurJOC https://t.co/NqKxfymSJN @IOCBPrague @Akademie_ved_CR @science_charles

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest paper on superanionic DNA displaying four different anionic groups (yes, even this can be synthesized by polymerase and it can hybridize!) just published in @NAR_Open https://t.co/0G2fhIwt91 @IOCBPrague @Akademie_ved_CR @science_charles

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest paper on solid-phase phosphoramidite synthesis of hypermodified ONs and DNA displaying four different functional groups has been published in @ACSOmega https://t.co/djvBoLVbky
@IOCBPrague @CzechAcademy @science_charles https://t.co/xjEAd7c9Jh

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest paper: Normalized Multipotential Redox Coding of DNA Bases for Determination of Total Nucleotide Composition | Analytical Chemistry. @IOCBPrague @CzechAcademy @science_charles https://t.co/HkttlwoEYF

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Real-time Imaging of Nascent DNA in Live Cells by Monitoring the Fluorescence Lifetime of DNA-Incorporated Thiazole Orange-Modified Nucleotides. @IOCBPrague @science_charles https://t.co/3yC94dWw0m

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Generic Platform for the Multiplexed Targeted Electrochemical Detection of Osteoporosis-Associated Single Nucleotide Polymorphisms Using Recombinase Polymerase Solid-Phase Primer Elongation and Ferrocene-Modified Nucleoside Triphosphates https://t.co/e4I1jBEfvs

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest paper on base-modified DNA aptamer against Hsp70 has been published in @CommsChem : https://t.co/bstJBYPW7k

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest paper on lipid-linked dNTPs for polymerase synthesis of lipidated oligonucleotides and anchoring to membranes has been published in @ChemicalScience. @IOCBPrague @CzechAcademy @science_charles https://t.co/92oBt5U01S

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest paper on TCO- and BCN-linked dNTP for metabolic labelling in live cells published on-line in @BioconjChem. @IOCBPrague @science_charles https://t.co/IgkkGkklvo

[Angewandte Chemie @angew_chem]

Chloroacetamide-Modified Nucleotide and RNA for Bioconjugations and Cross-Linking with RNA-Binding Proteins (Hocek) @IOCBPrague @hocekm #openaccess https://t.co/OOhrajGjBC

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Early view (open access) publication of our paper on reactive modification of #RNA for #bioconjugations and cross-linking with peptides and proteins in @angew_chem. @IOCBPrague @science_charles @CzechAcademy https://t.co/wHfVWA123H

[IOCB Prague @IOCBPrague]

New #research #ModifiedNucleotides #RNAprobes in @angew_chem

Chloroacetamide-Modified Nucleotide and RNA for Bioconjugations and Cross-Linking with RNA-Binding Proteins (@hocekm): https://t.co/qCdLQfbx9A

@IOCBPrague @science_charles

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest paper on chloracetamide-modified nucleotide and RNA probes for cross-linking with proteins published as Accepted article in @angew_chem https://t.co/CGOCzqB80q @IOCBPrague @science_charles

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest preprint on lipid-linked nucleoside triphosphates for enzymatic synthesis of hydrophobic oligonucleotides with enhanced membrane anchoring efficiency | ChemRxiv https://t.co/GJ6J0MOztf @IOCBPrague

[IOCB Prague @IOCBPrague]

#research #DNAlabeling #fluorescence #dNTPs
Nucleotides Bearing Red Viscosity-Sensitive Dimethoxy-Bodipy Fluorophore for Enzymatic Incorporation and DNA Labeling (@hocekm) - @BioconjChem: https://t.co/C4blgi5SuG

@IOCBPrague @science_charles @CzechAcademy

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest paper on viscosity-sensitive red-fluorescent nucleotides for DNA labelling has just been published in Bioconjugate Chem. https://t.co/QDME2Em3QZ @IOCBPrague @science_charles @CzechAcademy

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our first preprint and our first modified aptamer. Hope to have it published in a journal soon.

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our newest paper on C-H activation strategy in synthesis of novel fused nucleosides published in @J_A_C_S . https://t.co/ebqaZztqCp @IOCBPrague @science_charles @CzechAcademy

[Michal Hocek 🇨🇿 🇪🇺 🌍 🍷🧬🧪 @hocekm]

Our new paper on traceless enzymatic synthesis of hypermodified functionalized DNA polymers from RNA templates using DNA polymerases: https://t.co/oaFKHj0pKQ @IOCBPrague @CzechAcademy @science_charles