scorpionsstartedthis

Cathy Shanahan Laboratory:
We study the mechanisms of how blood vessels calcify and age.

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So pleased that our latest manuscript on mechanisms of vascular ageing was accompanied by a really informative editorial! Thanks to those who could see its significance! https://t.co/tLOsF6iova

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Highlighting an exciting PhD opportunity to apply for a project investigating epigenetics of vascular ageing in calcification. Chance to work in London and Singapore!
https://t.co/ywy5iJSiK3

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And this one highlights just how important ECM ageing is in modifying cell phenotype. Is it going to be possible to rejuvenate cells in vivo without first rejuvenating their ECM environment? https://t.co/1APTucyldg

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This was such a team effort! https://t.co/bkamDnNoqD

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We have a post-doctoral position available to study mechanisms of vascular calcification and ageing. Please get in touch if you are interested.

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https://t.co/JwU5jlPIS1

[Circulation Research @CircRes]

4/6 Sox9 Accelerates Vascular Ageing by Regulating Extracellular Matrix Composition and Stiffness by @FaleevaMaria @scorpionsstart1 et al https://t.co/zrr2Hu4ayn

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Our new paper identifies a novel feedback loop that links vascular ageing, stiffening and senescence via ECM remodelling mediated by Sox9.

https://t.co/J7lsoUMpW6

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@kingscardio
https://t.co/Kh3KFb2EM4

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Our new paper shows have EVs drive vascular amyloid depostion. Another role for EVs in an ageing pathology!
https://t.co/S4GCrj1ox3

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Our new paper shows have EVs drive vascular amyloid depostion. Another role for EVs in an ageing pathology!
https://t.co/S4GCrj1ox3

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@elonmusk Yes

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The evidence mounts that the DNA damage response is a key pathway driving biomineralization. Runx2 participates in the DDR and its modification via PARylation activates its key osteogenic targets.

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Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis… https://t.co/xqepf9zn6D

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@kingscardio @FindAPhD @FaleevaMaria @Kings_BHFCentre @TheBHF Well done Maria!

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Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Load… https://t.co/ChC4vEHulk

yet another vesicle cargo that is involved in calcification!

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Women political leaders key to 'more equal and caring societies' https://t.co/BRa7lbiZLk

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https://t.co/jJaZtiq0ui

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@abibrown_14 @Bruneluni @SanchiaAlasia Is there a link to the recording available - it would be an inspirational resource for our work in HE

[Equality, Diversity and Inclusion @UlsterEquality]

Thought-provoking webinar on Race Equality and White Privilege in Higher Education @Bruneluni @OpBlackVote Candid panel discussion on tackling race discrimination and the responsibility of all leaders to own the space. Every person benefits. #diversity #activism #RaceEqualityHE

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Great Speakers Enlightening Event

[maria.villarico @VillaricoMaria]

Excited to take part in today's event

@Bruneluni #raceequalityhe #blacklivesmatter

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Interesting read! Ageing signalling show specific pathological outcomes!

[ATVB: An AHA Journal @atvbahajournals]

This up-to date evaluation of the processes that govern vascular calcification highlights premature ageing, senescence and the cellular response to DNA damage as key drivers of biomineralizaiton. #calcification #smoothmusclecell #aging https://t.co/feyXCVEyjy