Caitlin M. MacCarthy

'..what darkness the mind of a great discoverer must grope, and what false tracks they will follow, before they see the light of truth.' ~Nature, Dec. 1920

[Caitlin M. MacCarthy @seemaccarthy]

Hold on to your🧦! In this trailblazing study @CellStemCell, we engineered a super-reprogramming factor that induces higher developmentally potent cells across species.
Check out our super-SOX, how it works, and how many species we reprogrammed and reset to naive pluripotency.

[Sergiy Velychko @velychko_s]

Great listen with @dwarkesh_sp and @jacobkimmel. Thanks for explaining super-SOX and the potential of synthetic reprogramming factors for age reversal!

[Sergiy Velychko @velychko_s]

Excited about @geochurch lab's latest paper at @emboreports, where I collaborated with @mpsmela1 to combine super-SOX naïve reset with his new set of factors to improve production of human oogonia - advancing towards iPSC-derived in vitro egg generation 🥚👶
https://t.co/MQzAqMQBPw

[Vlad Cojocaru @cojocarulab]

Proud to see this out now. We tried to give this topic a different perspective, put more weight on the MD simulations and NMR and look forward to the future that we believe should focus on dynamics.

https://t.co/2Bv4iqiSmT

[Oded Rechavi @OdedRechavi]

But can it run a gel?

[Sergiy Velychko @velychko_s]

Our Matters Arising preprint highlights the following issues with the Transient Naive Treatment (TNT) method for improved generation of human iPSCs published @Nature :
1. Characterization of bulk iPSCs rather than clonal iPSC lines;
2. Persistent Sendai virus expression in most samples even as late as passage 17;
3. Naive medium selects for high levels of Sendai resulting in overexpression of SKM
@thermofisher , we need a better CytoTune design! #notmySendai
https://t.co/I9YtAkxNkR
thanks to @delosangeles520 , @clemens_hug , @VadimGladyshev , @geochurch @harvardmed @MIT
TNT paper : https://t.co/mfNtFYJQV2 by @sambuckberry , @ry_lister , Jose Polo & colleagues

[Arun Sharma @ArunSharmaPhD]

And in the roundup:

1) A GENtoniK cocktail 🍸
@ejhergenreder @studerl @MSK_CSCB

2) Pancreatic organoids ♋️
@WCMSurgery @CellStemCell

3) Mammary organoids 🧫
@NCIResearchCtr @Dev_Cell

4) Chimeric super-SOX 🧦
@velychko_s @seemaccarthy

[Vikas Malik @vm0047]

Super thrilled to announce our latest breakthrough! Introducing gamechanger #supersox that enhances iPSC quality & generation from various species🐁🐖 🐄🐒👴🏼👵🏼 thnx @velychko_s @seemaccarthy @jauchr @geochurch Hans Scholer #StemCellResearch #breakthrough

https://t.co/3YxUz6CbiK

[Sergiy Velychko @velychko_s]

1. In the beginning there was Sox, and the Sox was Sox2.
A billion years later we created super-SOX:
https://t.co/TGi72mqGkH
Merry SOXmas! 🚀🧦

[Caitlin M. MacCarthy @seemaccarthy]

https://t.co/J2TDrPvRI8

Thanks to Sergiy and Hans for leadership and support! And to all the contributing co-authors for their hard work :)

[Caitlin M. MacCarthy @seemaccarthy]

Hold on to your🧦! In this trailblazing study @CellStemCell, we engineered a super-reprogramming factor that induces higher developmentally potent cells across species.
Check out our super-SOX, how it works, and how many species we reprogrammed and reset to naive pluripotency.

[Cell Stem Cell @CellStemCell]

Online Now! Highly cooperative chimeric super-SOX induces naive pluripotency across species https://t.co/fIuAUlTNgA #stemcells

[Ralf Jauch @jauchr]

Congrats to @haoqing_hu who led a team to show why it needs SOX17 rather than SOX2 to generate pluripotent and multipotent stem cells with high efficiency and quality @NAR_Open @hkumed
https://t.co/sVptyBRBAU

[eLife - the journal @eLife]

Today, we’re introducing a new model that eliminates accept/reject decisions.

By publishing every paper with eLife reviews as a Reviewed Preprint, we plan to restore autonomy to authors, ensuring that they will be judged by what, not where, they publish. https://t.co/OAsiOVFStI

[Caitlin M. MacCarthy @seemaccarthy]

Ever wonder what transcription factors look like in action?
Our study sheds light on the interplay between Oct4, histone tails, and nucleosomal DNA. Thanks @cojocarulab @janhuemar & all authors!
#allyouratomsareshowing #multidomainsTFshavemorefun(ctions)

https://t.co/tUMlVxW7xQ

[Sergiy Velychko @velychko_s]

Honored to present our unpublished work on enhancing the Yamanaka cocktail to Shinya Yamanaka himself at #GSCN2022, and to win a poster prize 🥂
Thanks to @seemaccarthy for her great contribution to the project and for capturing the moment :) @gscn_office

[Stem Cells NRW @StemCellsNRW]

Nobel laureate Shinya Yamanaka giving a lecture at the 10th @gscn_office and 20 Years @StemCellsNRW meeting. What an honour that he came all the way from Japan! @MKW_NRW @MPI_Muenster #GSCN2022

[GSCN @gscn_office]

The #GSCN2022 Conference & 20 years @StemCellsNRW has started! Great opening by Hans Schöler @MPI_Muenster and Fiona Doetsch. Looking forward to exciting 4 days. #stemcells @berlinnovation

[Caitlin M. MacCarthy @seemaccarthy]

A great kick off for the German Stem Cell Network Meeting 2022. @MPI_Muenster #nonPImeeting #GCSN2022

[Patrick Cramer @mpgpresident]

Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells. Fine collaboration of @LeXiong @lidschreiber @taras_velychko @LCaizzi with Schöler lab.
https://t.co/paVNCaoK3z @eLife

[Vlad Cojocaru @cojocarulab]

After 6 months of work, I'm happy to share a much improved article with lots of new data further strengthening our conclusions. Its great to see the progress from preprint versions. Thanks especially to @seemaccarthy and @janhuemar for this effort.
https://t.co/lkZU4bW3CW