steps to onboarding onchain
last cycle: get sol, go to this website, use these filters/settings, follow twitter accounts, somehow find a groupchat
this cycle: download an app
David Friedberg says Moderna is charging $500K for a ‘cancer vaccine’ that already exists
"What frustrates me the most about all of this, everyone's kind of lauding this as some unique breakthrough and special and powerful. It's not, a lot of people are going to places like Montana and getting peptides printed for their particular cancer sequence, making their own neo-antigens, and getting cured of their cancer.”
“You can pay someone $50,000 to do this for you today. There's a lot of clinics that will do it. And it's not a special FDA-approved drug. So why is Moderna saying that they're going to charge $500,000 for this?"
"I don't think that this technique, which has been developed through several decades of iteration, funded by NIH and other public funding dollars, should now be patented, FDA-approved, and charged half a million dollars for people to get treated for this."
"A private pharmaceutical company has seen their market cap go from $20 billion to $60 billion because they went through this regulatory process to create what, in my mind, is a form of regulatory capture.”
“They’re making the case that it's all about safety and trials, when fundamentally there's an underlying technique that was funded by a lot of public research dollars that I think should be more open-sourced, more ubiquitous. Every hospital should be trained on how to do this process to treat cancer patients.”
Chamath says Meta made the right move restricting social media for kids
"Thank you to Meta for solving my biggest problem, which is imposing limits on Instagram. I'm tired of playing whack-a-mole with my kids, and they have fake accounts and secret accounts and this and that. You should have done it sooner, but I'm glad you did it."
“I hope TikTok and YouTube do the same thing, and it'll make the life of a parent much simpler. It'll allow us to actually parent versus just policing device usage."
"It's exhausting being a parent of a child with a device. I applaud Meta for doing what they did. These limitations are coming around in Australia and Canada and the UK. It's physiologically and psychologically really helpful for kids to have these limits."
"These parental control apps aren't that great. They do a decent job. They don't do a great job. I'm always on my back foot as a parent, and it's frustrating. I would rather just spend time with my kids on other things other than screaming at them to get off their phone."
Jcal says AI generated writing is like lip syncing and finds it offensive
"I think it's the lip syncing of writing. As a writer, I find it offensive to let the system give your entire opinion, as opposed to using it for research, which is totally fine. Use it for proofreading, totally fine. But to me, it feels like I went to see Adele and she's lip syncing."
"If you were going to give your opinion and it's not written by you, that is disappointing that it's not disclosed. I think it's a much higher standard to say, I'm going to write this in my own voice."
"Sure, I could have somebody who's a ghostwriter help me polish it. I could check my grammar with it. I could do research with it. Those are all valid uses. But I don't like this idea that you're going to write something in AI and then I read it and I don't know. That to me feels icky and it feels insincere."
"I would prefer people to say upfront, I didn't write this, but I'm kind of in agreement with what the AI magic guessing word box said. I find it personally offensive."
Chamath’s message to anyone complaining about Druckenmiller using AI: “just shut the f*ck up and read what he says”
"I thought that it was the left that virtue signaled, but I actually think it's a class of people. And they judge and they can't see the forest from the trees. They're like the loudest chirpers in the peanut gallery."
"Stan Druckenmiller is the most incredible investor of our generation. Maybe top three or four. And so just shut the f*ck up and read what he says."
"You have an opinion and you're like, oh my God, he has an em dash. Oh my God, he used the AI flourish. You’re missing the script. He's telling you what's about to happen."
“The morons on X should be like, wait a minute, how does this affect my company? How does it affect my portfolio? How will it affect my 401k? What will it do to my parents' retirements? How should I think about hedging this? Instead, all of you people were like, oh my God, he was using AI.”
Sacks: "It's still written by him. He prompts it, he shapes it, he guides it. The take is his, and then he uses the AI to help him write it. You gotta be pretty dumb these days not to use AI to help you write. And he's definitely not dumb."
David Friedberg says Druckenmiller’s letter was written as cover for Bessent
“I think the note that Druck wrote, whether AI wrote it or he wrote it, it doesn't matter. The point of the note is correct. And the note is meant to provide cover to Bessent.”
“He is saying it is not Bessent's fault, or Bessent's responsibility to solve the yield curve problem. It is Congress's responsibility. It is the President's responsibility.”
“It is the responsibility of the holders of the budget and the accounts that should stand up and say, "We are going to cut spending," because if we don't cut spending, there is going to be a spiral which we are now going to face over the next 12 months as we have to refinance $10 trillion of debt.”
“I don't think they're allowed to talk. I don't think Druck's allowed to talk to Bessent. But I think that Druck is sending his signal to the market and saying, guys, the burden is not on his shoulder. He can't be Atlas. He can't lift this earth. He can't solve this problem. You guys have to act.”
Jcal says Sam Altman provoked Jensen into directly competing with OpenAI
"I think Jensen is going all in on open source based on these two acquisitions, Hugging Face and Poolside. I think Sam Altman poked the tiger."
"If you look at what he did, he had done that huge $100 billion deal with $NVDA back in 2025. Then he announced the $AMD deal. Jensen was clearly not pleased about that."
"Right after, Sam said he's going to make his own inference, jalapeño, and that he was going to do the deal with $AMD, then Jensen came out was like, 'Well, by the way, we don't actually have to do these investments in OpenAI.'"
"I think he's speed-running open source, and you're going to be able to buy your entire stack from $NVDA next year. He is going to own open source. That is a really interesting moment in time because we were sitting here 6, 12 months ago saying open source would never catch up."
"Jensen is doing an open source self-driving project. Now he owns Hugging Face, the leading open source indexer where everybody goes to try the new models.”
Chamath says the 30 year at 6% will signal the start of a death spiral
“The only solution is that Congress needs to come together and realize that they must now fix this problem. Because if you see 30 year yields at 6%, it is the beginning of a death spiral.”
“It's not going to be immediate, so don't freak out, but it is the beginning of some extreme pain, and that pain will last years.”
“The only thing that solves it now is getting the budget under control, which is a congressional act, it must happen. Whether it's this year or the next year, it just has to happen.”
David Sacks says the US is beating China in every AI category except one: optimism
"AI optimism in China is over 80%. They poll on the question, do you think AI will be more beneficial than harmful? Over 80% of Chinese people say yes. In the US that number is like 30%."
"The US is ahead of China in every category except one, which is optimism. The biggest risk to us winning this AI race against China is doing something and shooting ourselves in the foot because we're so pessimistic about what AI might do."
Jordi Alexander reveals the question about tradexyz and Hyperliquid's relationship that nobody wants to answer
"I got a bit of heat from the hype retards for talking about how we should have some understanding of what exactly the relationship is between Trade XYZ and the Hyperliquid ecosystem."
"Obviously it's symbiotic in some way, they're buying $HYPE, they're doing something that is aligned. It just hasn't been announced what that is."
"As a HYPE holder, which I still am, do I not deserve to understand if these fees are in any way going to be going back into HYPE or not?"
"For an $80 billion FDV asset, it makes sense to ask. If all the growth is in RWAs, are the token holders going to be getting it? And what's the deal?"
"They're aligned, but what does that mean? Are they going to buy $HYPE and burn it? Are they going to buy it and give it to their employees?"
"People don't want questions asked when they're holding a bag."
our stream today in 39 minutes
1:24 Warsh's first Jackson Hole
4:18 Callaway approved that ad?
9:43 GTA 6 is competing with pumpfun
17:12 Netflix is posting memecoins
19:22 market reacts to Warsh
22:12 @Impij25 interview
23:25 $500 to $250k on Polymarket
27:50 how to trade the Iran war
Neil Movva says losing TSMC wouldn’t be that bad
“If you look at TSMC five nanometer versus four versus three versus two, the performance per watt on these chips doesn't change a dramatic amount."
"People lose their minds over geopolitics, like what would happen if we lost access to TSMC for any reason? My contrarian take is that it wouldn't be that bad.”
“Supply would take a shock for sure. But the best processes that we have in the West, like Intel, are not that far behind. At worst, maybe two times worse performance per watt. And the gap is just far smaller than you would make it out to be."
Chamath (May 2026) says high end SaaS is safe and the SaaS market might be oversold
“I think the low end of the market is basically finished. I think there is no safe space. I think the high end of the market where Mark operates, where the large monoliths operate, is quite safe."
"I think we're a little oversold. I now think this consolidation and the rerating can happen in the opposite direction.”
“What is the opposite trade? The opposite trade is who has constructive net dollar retention, who has negative churn that's been really predictable, which is a way of saying who has the best relationships."
"Because eventually the next trade that has to happen is when the public markets become a little bit less breathless about AI and they ask one simple question: okay guys, you've spent three trillion dollars in the last four years. What is the ROI of these tokens?"
"What's going to happen is you're going to have to go to guys like Marc Benioff and say, please sell my tokens. That's the next shoe to drop. Those will come way back down and I think these go back up and you'll find a balance."