Sara Šepić

PhD student at @MPI_Biochem | Interested in biochemistry and structural biology 👩🏼‍🔬

[Jakob Farnung @jakobfarnung]

🎉Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab. Special shutout goes to @matthias_muhar
https://t.co/MtiWUyJeyT

[Jakub Chrustowicz @chrustowicz_j]

Thrilled to share our latest preprint describing discovery of the charged, metabolically activated molecular glue degrader engaging the basic pocket of the structural CRBN homolog, YPEL5 - a subunit of the giant GID/CTLH E3 ligase!!!

https://t.co/XcAdbj7PNZ

[Sara Šepić @sepic_sara]

@dawafutisherpa @maxplanckpress @MPI_Biochem @ArnoAlpi @chrustowicz_j Congrats Dawa 🥳 well deserved!

[Sara Šepić @sepic_sara]

Check out the study on the first identified human protein whose stability is regulated via Pro/N-degron and CTLH E3 ligase

[Molecular Cell @MolecularCell]

Online Now: mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway https://t.co/a9lxS3uqtO

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

Alpi, Schulman, Mann and Murray labs decipher regulation of human NMNAT1 (NAD+ biosynthetic enzyme) by gigantic WDR26-CTLH E3 ligase complex!

❕https://t.co/GFJFQkZLjs

#ubiquitin #E3ligase

@Karthik_G_Varma @chrustowicz_j @dawafutisherpa @ArnoAlpi @labs_mann @pjmurray_lab

[Yasin Dagdas @PlantoPhagy]

@ArnoAlpi is telling us about Non-canonical substrate recognition by E3 ligases. See one of their recent papers: https://t.co/XzZP8WKqJ7 #ubfriends2024

[Jakub Chrustowicz @chrustowicz_j]

How does multisite #phosphorylation of an #E2 enzyme dictate its pairing with a multisubunit #E3 #ubiquitin ligase to regulate metabolism? Check out our story available now in @MolecularCell!

➡️ https://t.co/rAQe0E9Bju

@dawafutisherpa Schulman lab @MPI_Biochem

[Molecular Cell @MolecularCell]

Online Now: Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies https://t.co/bZmY0VhCqD

[IMPRS-ML @IMPRS_ML]

Prof. Brenda Schulman introducing the new IMPRS-ML 👏🏻🆕 @MPI_Biochem
#newbeginnings #launchday #IMPRSsiveMinds