Jakub Chrustowicz

Structural biologist at @Amgen | South SF, previously a postdoc and PhD student at @MPI_Biochem | Schulman lab
dissecting molecular mechanisms of GID E3 ligases

[Jakub Chrustowicz @chrustowicz_j]

Thrilled to share our latest preprint describing discovery of the charged, metabolically activated molecular glue degrader engaging the basic pocket of the structural CRBN homolog, YPEL5 - a subunit of the giant GID/CTLH E3 ligase!!!

https://t.co/XcAdbj7PNZ

[Daniel Scott @Daniel_C_Scott]

Principles of paralog-specific degradation engaging the C-degron E3 KLHDC2, now out @SpringerNature @NatureComms
Awesome collaboration with @Richard_E_Lee and Taosheng Chen labs.
@StJudeStructBio @MPI_Biochem @StJudeResearch #TPD #PROTAC #SchulmanLab

https://t.co/FqdbKTGiaR

[Roman Sarott @RomanSarott]

Can we turn the activity of oncogenic kinases against cancer itself?
In my postdoc work @Stanford, new in @sciencemagazine, we show exactly that.
https://t.co/PZjQxvab7z
#ScienceResearch #InducedProximity @Stanford_ChEMH @StanfordCancer @snsf_ch @StanfordMed

[Ryan Potts @pottslab]

🔬 Neat discovery in protein degradation. Gray, Schulman, et al labs unveil ZZ1, a prodrug for charged molecular glues that target disease-causing proteins via the GID/CTLH ubiquitin ligase complex. https://t.co/edD6U04h0z

[Jakub Chrustowicz @chrustowicz_j]

A great collaborative effort between @zhezhuang7, @WoongSubByun and Stephen M. Hinshaw at the Gray’s lab @Stanford, @StanfordMed, the Schulman lab @MPI_Biochem, and @zkozicka and Mikołaj Słabicki @biomiko at the Ebert’s lab @DanaFarber, @HarvardMed, @BroadInstitute!!!

[Jakub Chrustowicz @chrustowicz_j]

Thrilled to share our latest preprint describing discovery of the charged, metabolically activated molecular glue degrader engaging the basic pocket of the structural CRBN homolog, YPEL5 - a subunit of the giant GID/CTLH E3 ligase!!!

https://t.co/XcAdbj7PNZ

[FEBS Letters @FEBS_Letters]

⭐️ Editor's Choice article:

Mutations in WDR26 associated with #SkrabanDeardorffsyndrome (#SKDEAS) impair CTLH E3 complex assembly

➡️ https://t.co/oDwLlLWi6W

@pjmurray_lab @MPI_Biochem

[Jakub Chrustowicz @chrustowicz_j]

Check out our story revealing exciting regulation of the NAD+ biosynthetic enzyme NMNAT1 by the supramolecular CTLH E3 ligase assembly out in @MolecularCell!

➡️https://t.co/Fn3Hx7o38o

Karthik Gottemukkala, @dawafutisherpa, @ArnoAlpi

Schulman lab @MPI_Biochem

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

Wow! CUL9 is a GIANT E3 ubiquitin ligase!  See unique cullin-RING-RBR all-in-one. +/- NEDD8.

Now online in Nature Structural & Molecular Biology by Schulman Department

❕https://t.co/G9y74fJONK

#ubiquitin #E3ligase #cryoEM
@DHornGhetko @LinusHopf @labs_mann @NatureSMB

[Frank Adolf ❄️🔬🧬 @frank_adolf]

🚨Excited to share that our manuscript is now published in @NatureSMB. Using #cryoEM 🔬we obtained multiple snapshots 📷 of the #chaperone-mediated multistep assembly pathway of the human 20S #proteasome.

@MPI_Biochem @HarvardCellBio @ASAP_Research

https://t.co/1oJ1hiIRbR

[Peter J Murray @pjmurray_lab]

Here is the link to our SKDEAS paper: 10.1002/1873-3468.14866. And I love this figure. Maybe useful for the @Skdeas.org effort.

[Peter J Murray @pjmurray_lab]

Back after an Easter X-break with a new paper from PhD student Annette Gross, @ArnoAlpi and the Schulman team explaining how the huge spectrum of WDR26 mutations is involved in #Skraban-Deardorff intellectual disability syndrome

[Joanna Liwocha @JoannaLiwocha]

Now out in @MolecularCell! High-resolution structure showing direct ubiquitylation of a #TPD substrate! And much more, check out 👉https://t.co/fZcP5DZcFf #cryoEM @MPI_Biochem @UNLV_CoS @StJudeResearch @DanielS20127197 @rajanprabu

(1/2)

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

How does multisite #phosphorylation configure the catalytic E2-E3 assembly for metabolic enzyme targeting?

Check out our story available now in its final version in @MolecularCell!
❕https://t.co/NjETPtjl7b

@chrustowicz_j @dawafutisherpa #ubiquitin

[Jakub Chrustowicz @chrustowicz_j]

How does multisite #phosphorylation of an #E2 enzyme dictate its pairing with a multisubunit #E3 #ubiquitin ligase to regulate metabolism? Check out our story available now in @MolecularCell!

➡️ https://t.co/rAQe0E9Bju

@dawafutisherpa Schulman lab @MPI_Biochem

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

Which cullin-RING E3 #ubiquitin ligase directs your favorite pathway or your #DegraderDrug?

Our conformation specific antibody and probing of active #CRL E3 complexes is in @nchembio!

❕https://t.co/WST68AtFr1
❕https://t.co/uOo8UaA9uj

@labs_mann @pjmurray_lab @LukasHenneberg

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

In preparation for the Louis-Jeantet Prize ceremony, we accompanied the @LouisJeantetFDN video team to shoot parts of the video about our director Brenda Schulman, @iDikic2 and their amazing research in the #ubiquitin field.

Watch the full video here:
➡️ https://t.co/yWpTpLjXed

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

Systemwide multiprotein complex formation visualized!
CAND1 recycles Cullin-RING complexes to produce E3 #ubiquitin ligases. Averts cellular supply chain problems, prevents buildup of unneeded molecular machines & rapidly establishes degradation pathways
➡️https://t.co/k7El270V0L

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

📣 Amazing News!

We're happy to announce, that Brenda Schulman receives an ERC Advanced Grant for her project UPSmeetMet!

Congratulations to all ERC-Awardees! 🎉

➡️ more: https://t.co/STVQoC7BOC

@ERC_Research #ERCAdG #Ubiquitin

[Nature Reviews Molecular Cell Biology @NatRevMCB]

Now Online C-degron mimicry confers E3 ligase selectivity https://t.co/lbxo6ohOH6

[Max Planck Institute of Biochemistry (MPIB) @MPI_Biochem]

#Ubiquitin ligase substrate selectivity regulated kinetically by E3 self-degron mimicry.

International effort by Schulman lab, @DanielS20127197 Scott & Moeko King & team @StJudeResearch @KheewoongBaek @MPI_Biochem & Gary Kleiger @unlv

➡️ https://t.co/T87thPUT4w