Roman Sarott

PI at Max Planck Institute for Medical Research | Chemically Induced Proximity | Gain-of-Function | Stanford Postdoc | PhD 2021 ETH Zürich

[Ingo Hartung @HartungIngo]

Nathanael Gray @StanfordUChem about bifunctional proximity-inducing molecules which allow to rewire transcription #AACR26. TCIPs hijacking BCL6, BRD4, CDK9, p300 and p53 Y220C as “synthetic hybride TFs” leading to transcriptional hyperactivation & gain-of-function pharmacology.

[Roman Sarott @RomanSarott]

@ailaxavia WA

[Dan Nomura @DanNomura]

Cool paper from Crabtree and Gray labs: https://t.co/GfevVv6lQX

[Max Planck School Matter to Life @mattertolife]

🚀 Great news!
With support of the Dieter Schwarz Foundation, the #MaxPlanckSchools will keep growing. The funding boosts top-tier research & training—#ShapingTheFuture of science! Read more at https://t.co/UxEiJKmxgq

@maxplanckpress
@HRK_aktuell

[William Gibson @wgibson]

Happy to announce my next career step - I’ve launched my independent research lab at Dana Farber!

If you are a trainee interested in ambitious projects at the intersection of chemical biology and cancer biology, please reach out!

https://t.co/HeBrFiAzM8

[Svetlana Tsogoeva @Tsogoeva_Group]

Explore the outstanding contributions by @francesarnold, @AlisonNarayanUM, @FlitschSabine, @HartwigGroup, @CarreiraGroup, @Shenvi_Lab, @hanzyduzit, @AdibekianG, @DrNitinAPatil, @RomanSarott, @ziyangnickqin, @LauraMBohnPhD1, @SHIONOGI_JP @ACSCentSci https://t.co/7EzPThp9m6

[Roman Sarott @RomanSarott]

Can‘t wait to get started!🥳 Thank you @mpi_mr_hd for making my transition so smooth:)

[Max Planck Institute for Medical Research @mpi_mr_hd]

🎊🎉Exciting news: @RomanSarott will join us in January as a new Research Group Leader and will establish the group “Chemically Induced Proximity”. We look forward to seeing you again in January, dear Roman! 🤩👏https://t.co/Zmigtft0XB

[Max Planck Institute for Medical Research @mpi_mr_hd]

🎊🎉Exciting news: @RomanSarott will join us in January as a new Research Group Leader and will establish the group “Chemically Induced Proximity”. We look forward to seeing you again in January, dear Roman! 🤩👏https://t.co/Zmigtft0XB

[J. Am. Chem. Soc. @J_A_C_S]

Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from Multicomponent Combinatorial Library JACS @fischerlab1 @DanaFarber @harvardmed @Stanford @StanfordMed @StanfordCancer @RomanSarott #CRBN #Wee1 #MolecularGlue #Degraders #Multicomponent #Library https://t.co/4HeoUCazcB

[Roman Sarott @RomanSarott]

@HRazumkov @ZzzxJiang here with link that works for non-Stanforders...
https://t.co/HCAjozPYKH

[Roman Sarott @RomanSarott]

Multicomponent reactions for molecular glue discovery,
Congrats @HRazumkov and @ZzzxJiang !

Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library | Journal of the American Chemical Society https://t.co/aZ1DPS4nz2

[Uri Alon @UriAlonWeizmann]

Postdoc opportunity to work with Weizmann and Max Plank, superb funding. Enjoy the best of both worlds.

https://t.co/kmKRDtxti4

[Roman Sarott @RomanSarott]

Bivalent molecules unmute silenced genes https://t.co/DsOCsFelxP

[Radek Nowak @RPNowak]

We can now activate p53 Y220C by recruiting BRD4 to it with small molecule TRAP-1. This was a great collaboration with Gray lab and Attardi Lab @Stanford lead from @UniBonn @UniklinikBonn by @dpienkowska9 & @JanGerhartz.
https://t.co/kvAr0vHno8

[Ryan Potts @pottslab]

New work from Nat Gray lab...
Discovery of a small molecule chemical inducer of proximity that activates mutant p53 by linking to BRD4. Highlights how chemically induced proximity can be used to restore the functions of tumor suppressor proteins.

https://t.co/CBQTjpRhpW

[Roman Sarott @RomanSarott]

Fantastic feature story on our work on hijacking kinases to kill cancer cells - thank you @JuliaBauman2 for the highlight!

[Julia Bauman @JuliaBauman2]

Really nice new cancer drug modality: Chemical induction of proximity to hijack the activity of a cancer driver!

From @RomanSarott @saigourisankar @baselakarim in the Gray & Crabtree labs @Stanford

[Roman Sarott @RomanSarott]

https://t.co/zfQfUJjL0z

[Roman Sarott @RomanSarott]

@NikolasKlink @Stanford @ScienceMagazine @Stanford_ChEMH @StanfordCancer @snsf_ch @StanfordMed Thank you, Niko!

[Roman Sarott @RomanSarott]

Can we turn the activity of oncogenic kinases against cancer itself?
In my postdoc work @Stanford, new in @sciencemagazine, we show exactly that.
https://t.co/PZjQxvab7z
#ScienceResearch #InducedProximity @Stanford_ChEMH @StanfordCancer @snsf_ch @StanfordMed

[Roman Sarott @RomanSarott]

If precision gene modulation with small molecules sounds fun - my starting lab @mpi_mr_hd is looking for postdoc candidates in molecular biology!

[Roman Sarott @RomanSarott]

@Jeff_Mold Thank you very much, Jeffrey!