The Hartwig Group

Student-run twitter account for the Hartwig Group at UC Berkeley. 🧪

[The Hartwig Group @HartwigGroup]

The group goes to John’s house for good food and a great time! Tap to see a very proud John of his paella 🥘

[J. Am. Chem. Soc. @J_A_C_S]

3D, Structure-Based,
Deep Learning Approach to Predict
the Regioselectivity of Olefin Hydroformylations https://t.co/nuYQOQEHjE

[Machine Learning (ML) Papers @Memoirs]

LatentFlow: Visual Analytics for Latent Space Analysis in Molecular Graph Neural Networks

Shiyi Liu, Jiaqing Chen, Nicholas Hadler, Rostyslav Hnatyshyn, Michael W. Mahoney, Talita Perciano, John F. Hartwig, Gunther H. Weber, …
https://t.co/Q40v07g9LH [𝚌𝚜.𝙻𝙶 𝚌𝚜.𝙷𝙲]

[The Hartwig Group @HartwigGroup]

We are extremely excited to be part of the Genesis Mission and develop new ML models designed for the unique challenges of synthetic chemistry to discover and design next generation catalysts faster!

[College of Chemistry @UCB_Chemistry]

Out of thousands of proposals, the College of Chemistry was chosen as 1 of 278 teams awarded @energy Genesis Mission funding! Prof. John Hartwig & team are using AI to solve chemistry’s "small data" problem—unlocking next-gen catalysts. @HartwigGroup https://t.co/0y6nBhXmma

[The Hartwig Group @HartwigGroup]

Can whole-cell biosynthesis by artificial metalloenzymes escape from E. coli-land? We're Gram-positive!

See how we leveraged a Streptomyces albus chassis for iridium-catalyzed cyclopropanation—now in JACS!

In collaboration with the @Keasling_Lab.

https://t.co/0AxfLg9MxY

[The Hartwig Group @HartwigGroup]

Hot off the presses! C-H activation by uranium oxo photocatalysis--now made site-selective by ligand control. Longer lifetimes. Higher activity. All possible with blue light.

In collaboration with the lab of @ProfArno.
Now in JACS: https://t.co/sVa4W9v4dS

[SynStrategy @SynStrategy]

The newest update to @SynStrategy is live, bringing a top requested feature: a quiz function! Save reactions to custom datasets and test your knowledge across 3 quiz or flashcard formats. Check it out!

iOS: https://t.co/7MJbW69q0p
Android: https://t.co/mUV0h28A99

#ChemTwitter

[Congjun Yu @CongjunY]

This is fantastic!

[The Hartwig Group @HartwigGroup]

Our postdoc @Willi_Amberg built @SynStrategy a learning tool that categorizes 500+ reactions by functional group with 400+ total synthesis examples. If you’re into #OrgChem, check it out (it’s free)!

iOS: https://t.co/vTpNTwl4ZU
Android: https://t.co/yMQsiJUZU6

#ChemTwitter

[J. Am. Chem. Soc. @J_A_C_S]

Mechanism-Inspired Ligand Design for Efficient Copper-Catalyzed C–N Coupling of Aryl and Heteroaryl Chlorides | Journal of the American Chemical Society @UCBerkeley @UCB_Chemistry @HartwigGroup https://t.co/FqXKux8TZq

[J. Am. Chem. Soc. @J_A_C_S]

Observed versus Predicted Reactivity, Selectivity, and Mechanism of Iridium Catalysts with Pyridyl Carbene Ligands for the Borylation of C–H Bonds | Journal of the American Chemical Society @UCBerkeley @HartwigGroup https://t.co/jOhcIaO26H

[Boron-Chem-Research @Boron_Chemistry]

Observed versus Predicted Reactivity, Selectivity, and Mechanism of Iridium Catalysts with Pyridyl Carbene Ligands for the Borylation of C–H Bonds (@J_A_C_S): https://t.co/rlb7kCwcpa (@HartwigGroup).

[J. Am. Chem. Soc. @J_A_C_S]

Illuminating the Effects of Interchain Interactions on the Catalytic Amidation of C–H Bonds in Polyethylenes | Journal of the American Chemical Society @HartwigGroup @UCB_Chemistry @UCBerkeley https://t.co/wRJYpNGjDB

[Boron-Chem-Research @Boron_Chemistry]

Mapping the Undirected Borylation of C(sp3)–H Bonds in Strained Rings (@J_A_C_S): https://t.co/DOPWYSShuZ (@HartwigGroup).

[J. Am. Chem. Soc. @J_A_C_S]

Mapping the Undirected Borylation of C(sp3)–H Bonds in Strained Rings | Journal of the American Chemical Society @HartwigGroup @UCBerkeley @UCB_Chemistry https://t.co/jRbFrfBGAs

[Ambeed Inc @ambeedinfo]

#AmBeedNewsletter ✨ Recently, the Hartwig Group (@HartwigGroup) reported an inexpensive, mild, and soluble base suitable for small & large scales with excellent functional group tolerance. This work has been published in @J_A_C_S.
💡Key Highlights
✅ New L147/K‑2‑EH system enables mild and efficient C–N coupling of diverse amines with aryl halides/nonaflates.
✅ Excellent tolerance for base-sensitive functional groups.
✅ Over 6,000 substrates analyzed; 28 nucleophile and 16 electrophile clusters mapped.
✅ QSRR models identify key structural features for reactivity.

The author mentioned in supporting information that some of the starting materials were purchased from AmBeed. We are honored to contribute to this groundbreaking research.
📚🔻 𝐑𝐞𝐚𝐝 𝐦𝐨𝐫𝐞 𝐰𝐢𝐭𝐡 𝐀𝐦𝐛𝐞𝐞𝐝
https://t.co/Gd93408xox

#OrganicChemistry #PdCatalysis #MedicinalChemistry #DrugDiscovery #AmBeed #UTD #JACS

[The Hartwig Group @HartwigGroup]

Check out this blog post by Derek Lowe in @ScienceMagazine where he uses our new C-N coupling method developed in collaboration with @abbvie!

https://t.co/vYKg40K7wa

[The Hartwig Group @HartwigGroup]

Excited to share our new method for Pd-catalyzed C–N cross-coupling, now published in @J_A_C_S !

This method utilizes an inexpensive, mild, and soluble base suitable for small & large scales with excellent functional group tolerance.

https://t.co/xnNREvcBfR

[Arseniyadis @arseniyadis]

Catalytic organometallics ✔️
C-H functionalization ✔️
Olefin hydrofunctuonalization ✔️ Enantioselective allylic amination ✔️
Polymer upcycling ✔️
…and now artificial metalloenzymes💥

@HartwigGroup
#JCO2025

[J. Am. Chem. Soc. @J_A_C_S]

Site- Stereo- & Chemoselective Enzymatic Terpeneoid Halogenation by Substrate Masquerade | Journal of the American Chemical Society @UMichResearch @UMich @Michiganchem @NarayanLab @AlisonNarayanUM @UCBerkeley @UCB_Chemistry @JohnFHartwig1 @HartwigGroup https://t.co/AA95anv3sz

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2025 #NobelPrize in Chemistry to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal–organic frameworks.”