Sergio Rodriguez

MIT | Biological Engineering, PhD Student, Love Lab

[Sergio Rodriguez @sergrodzMIT]

Shout out to @kindofabigneil, the Love Lab team and the Damron Lab from WVU!

[Sergio Rodriguez @sergrodzMIT]

New preprint out from the LoveLab at @MITChemE @kochinstitute. We modified a cryptic epitope in the SARS-CoV-2 RBD to make it more manufacturable and eliciting greater breadth to variants of concern.

https://t.co/M7UF46yNOz
(1/4)

[Sergio Rodriguez @sergrodzMIT]

After challenging mice that were vaccinated with a three VLP-RBD doses, we show that RBD-S383D-L452K-F490W-L518D (RBD-J6) elicited neutralizing activity similar to two doses of Comirnaty.
(4/4)

[Neil Dalvie @kindofabigneil]

We have a new preprint from the Love Lab at @MITChemE @kochinstitute that should be of interest to the #pichia community and anyone who routinely expresses recombinant proteins in eukaryotes

https://t.co/9ELiTwTKj5

1/3

[Neil Dalvie @kindofabigneil]

The preclinical data for our protein subunit COVID-19 vaccine is now published in @ScienceAdvances! Reflects the work of an awesome team at @MITChemE @kochinstitute @BIDMChealth @harvardmed led by @LisaTostanoski and @sergrodzMIT 1/3:

[Sergio Rodriguez @sergrodzMIT]

Awesome job from the whole team!

[Neil Dalvie @kindofabigneil]

Our #Covid_19 protein vaccine antigen was published in @PNASNews a few weeks ago.

The engineered RBD has improved manufacturing titer, stability, and immunogenicity - all are critical to supply vaccines to low-income countries.

https://t.co/MOqVzfCIsd

[Neil Dalvie @kindofabigneil]

Our #Covid_19 protein vaccine antigen was published in @PNASNews a few weeks ago.

The engineered RBD has improved manufacturing titer, stability, and immunogenicity - all are critical to supply vaccines to low-income countries.

https://t.co/MOqVzfCIsd

[Neil Dalvie @kindofabigneil]

Our new preprint reports preclinical testing in primates of a new protein subunit vaccine for #COVID19 being developed at @SerumInstIndia. Ab titers similar to approved vaccines, and protection from challenge.

1/3

[Neil Dalvie @kindofabigneil]

The Love Lab @MIT has been working on #COVID19 vaccine development with a focus on #manufacturing from the beginning - the only way to reach @gatesfoundation’s goal of several billion affordable doses.

@BillGates @melindagates @techreview @MITChemE
https://t.co/W1UW6m85TE

[Neil Dalvie @kindofabigneil]

Our preprint from the Love Lab at @MITChemE is up, describing engineering of the #SARSCoV2 RBD (the receptor binding domain of the spike protein).

Two amino acid changes make the RBD easier to manufacture, more stable, and, surprisingly, more immunogenic.

1/4