Hunter Shain

Associate Professor, Dermatology, UCSF. part of HTAN. Melanoma, skin cancer, single-cell, DNA/RNA-seq, spatial transcriptomics, cancer, dermatology, pathology

[Hunter Shain @ShainLab]

Excited to share that our paper, “Somatic mutations distinguish melanocyte subpopulations in human skin,” is now out in Nature Cell Biology.
Reposting the thread below ⬇️

[Hunter Shain @ShainLab]

Happy to share the latest preprint from our lab, “Somatic mutations distinguish melanocyte subpopulations in human skin”. https://t.co/snOmhQZ7k1 [1]

[Hunter Shain @ShainLab]

@aemonten The blue place is not really any better. LI is where I get the most scientific engagement these days, but it is not an ideal platform for many things

[Noah Zimmerman @_noahzim_]

Heading to #ASCO this week and really looking forward to the energy and the science.

On a personal note, I’m proud to share some work my team is presenting this year. I want to briefly highlight why I think these results matter.

[Linghua Wang, MD, PhD @IamLinghua]

1/ Thrilled to share our new paper, out today in @ScienceMagazine! We built a pan-cancer spatial atlas of tertiary lymphoid structures (TLSs) and developed computation and AI frameworks to study TLS biology at scale.
https://t.co/zgcBnnm7Rl

[Hunter Shain @ShainLab]

@JohnStreicher1 SABV was created with good intentions, but it turned into a stock reviewer critique. That is frustrating.

[Hunter Shain @ShainLab]

@RongFan8 Is this where Crick and Watson would brainstorm the structure of DNA over beer? Nice!

[Hunter Shain @ShainLab]

@srikosuri One could go even further to account for differences in class difficulties, such as an ELO score -- similar to what they do in college sports to account for scheduling differences.

[Hunter Shain @ShainLab]

@SyedAAhmad5 This is misleading. The Kaplan-Meier curves represent physicians "in this study population that are not currently practicing (N = 521)". It helps compare men vs women who left but not overall rates of attrition

[Benjamin Mazer @BenMazer]

Marty Makary misunderstood something fundamental about the FDA

There is not, and never has been, a ‘deep state’ to shove aside

https://t.co/Kpmp7I6IBL

[Ezra Klein @ezraklein]

On Friday, I hosted a forum with the top 5 Democrats running for governor of California on how they'd fix the state's housing crisis. Some really interesting moments, including this one, from @katieporterca, on California Forever and master-planned communities.

Full forum on podcast apps/Youtube.

[Sonal @sonalrashmi1510]

Excited to share SapiensOntoCellMap! 🚀 An open-source tool for ontology-aware, hierarchical cell type annotation of scRNA-seq and spatial transcriptomics data.
​Built at @UCSF to solve a major gap: moving beyond simple labels to true biological context. 🧵👇

[Rong Fan @RongFan8]

Excited to see this in print! Kudos to Haikuo, Bo, and the entire team including @MinaXu7 @yalepathology @zhou_jingtian @arcinstitute to explore this clinically relevant area of lymphoma transformation with truly innovative technology. @theNCI #HTAN
https://t.co/mcQdE1Esny

[Hunter Shain @ShainLab]

Now do San Francisco

[Nate Silver @NateSilver538]

@TheStalwart Yeah it's 70% human capital, 15% the food (underrated not overrated), 8% the subway, 6% that NYC is actually really pretty and 1% the Knicks when they're winning.

[Hunter Shain @ShainLab]

Original publication is here, though the software has been through many versions since the original manuscript was published. https://t.co/KyCuATmj4L

[Hunter Shain @ShainLab]

STmut can now operate on Atera data from @10xGenomics. Here is a breast cancer that was profiled on the Atera platform

[Hunter Shain @ShainLab]

STmut can be downloaded here. https://t.co/kc1zjoM1X3. Thanks to @liminchen15 for creating the software and continually updating it to handle higher resolution spatial transcriptomics, as they are rolled out. Thanks to Vignesh Arunachalam for generating the present figures.

[Hunter Shain @ShainLab]

@MinaXu7 Where is Pathologist?! The percent keeps creeping up, but I think you're safe

[Hunter Shain @ShainLab]

@IamLinghua @UTMDAnderson That is exciting! Cannot wait to see what you accomplish with this generous support