Sharon Yang

now: @coeff_giving. before: @KamalaHarris, @WhiteHouse, other campaigns & candidates. always: hoping to wrest the @sharonyang handle from the bot that owns it.

[Alexander Berger @albrgr]

I’m really excited about the Strep A Vaccine Fund we’re launching today. IMO the basic case here is a great recipe for impact:

→ A huge problem: ~1% of total annual deaths worldwide (>600k)
→ Super neglected: ~$14M/yr of R&D globally before this, ~50x less than malaria which has similar mortality
→ Newly tractable: new human challenge models and earlier diagnostics should speed the path to an approved vaccine

Grateful to our partners Adam and Abigail Winkel, Good Ventures, Lucy Southworth, @ThePatchworkCLT, and a few anon donors for getting us to >$140M at launch. We’re continuing to actively fundraise and think we could effectively spend >$200M over the next few years. Our goal is to double the number of Strep A vaccine candidates in clinical trials and have at least one ready for Phase 3 trials by the end of 2030.

And I’m thrilled to be betting on Katharine’s vision here! As a grad student, she co-invented the R21 malaria vaccine that’s now reaching millions of kids. I’m hoping to see hundreds of millions of future Strep A vaccine doses with her fingerprints on them.

[Coefficient Giving @coeff_giving]

Today we're launching the Strep A Vaccine Fund: a new multi-donor initiative to accelerate vaccine development against one of the world's most neglected infectious diseases, relative to its scale 🧵

[Alexander Berger @albrgr]

.@coeff_giving directed over $1b in 2025, the most in our history.

I wrote a more personal annual letter this year, focusing on what a decade of grantmaking has taught me, how I'm thinking about AI, and how we're grappling with giving at this scale. 🧵

[Bryan Walsh @bryanrwalsh]

Open Philanthropy is now Coefficient Giving—a shift from one anchor donor to many, with pooled funds built to scale impact, like the $120M Abundance & Growth Fund). I spoke with CEO Alexander Berger for @voxdotcom about how to grow rigor, not just dollars https://t.co/hTQwqZDq74

[Alexander Berger @albrgr]

Some news: Open Philanthropy is now Coefficient Giving! Our mission is unchanged but the new name reflects our growing work with other donors to multiply the impact of their giving.

🧵 on our work to make philanthropy a more efficient "market" and plans going forward:

[Alexander Berger @albrgr]

CA Governor Newsom just signed SB 79, an important bill to make homes easier to build near transit, and arguably the biggest YIMBY win to date.

Some reflections on the bill & the history of how we got here 🧵

[Joseph Costello @costellojoseph_]

.@AnisimovaAmanda YOU WILL BE BACK. We support you! 🇺🇸🇺🇸🇺🇸

[Matt Clancy @mattsclancy]

The Abundance and Growth Fund at Open Philanthropy is hiring! We’re looking for 2-4 people to help expand this new $120+ million program to accelerate economic growth and reduce the cost of living through strategic grantmaking and research. (1/4) https://t.co/45KOarYLyY

[Sharon Yang @sharonjqyang]

@chipiaje_sara @OversightDems @RepRobertGarcia let’s goooo

[Alexander Berger @albrgr]

Very cool work from a grantee!

[Coefficient Giving @coeff_giving]

1/6 Our Global Health and Wellbeing staff often use back-of-the-envelope calculations, or BOTECs, to estimate a grant’s potential impact. A 🧵 on some real-life examples from OP grantmaking:

[Alexander Berger @albrgr]

Cool to see Cari and Dustin highlighted in TIME100 Philanthropy today. They don't toot their own horns much, but they've given over $4b so far - I believe they're the youngest billionaires to have given such a high proportion of their wealth away.

[Sharon Yang @sharonjqyang]

For years, @open_phil has funded the development of new vaccines, drugs, and other tools to improve global health.

Here's more from our Senior Program Officers Chris Somerville and Heather Youngs on the importance of efforts to find a better TB vaccine:

[Sharon Yang @sharonjqyang]

TB is one of the deadliest infectious diseases on earth –killing 1 million+ every year.

@open_phil has long supported TB vaccine research, including Dr. Sarah Fortune's.

This week, we were able to step in on 24 hrs notice to ensure her work continues >>
https://t.co/ORUdRTuZWN

[Sharon Yang @sharonjqyang]

some professional news: thrilled to be joining the amazing team at @open_phil and supporting its important mission of high-impact giving to help others as much as possible with the resources available.

excited to get to work!!

[Abby D. Phillip @abbydphillip]

Just in: 110-year old Viola Ford Fletcher, the oldest survivor of the Tulsa Race Massacre voted today in Oklahoma. I’m told she voted for Vice President Harris.

[Joey Garrison @joeygarrison]

VP Harris did interviews today on drive-time radio stations in PA, GA and NC, per campaign. (Power 99 in Philadelphia with Cappuchino, and KDKA NewsRadio in Pittsburgh with Larry Richert, The Big Tigger Morning Show on V103 Atlanta, and Foxy 107.2 with Karen Clark in Raleigh, NC)

[Sharon Yang @sharonjqyang]

Good morning!!!!

[Headquarters @HQNewsNow]

It’s Election Day. Let’s make our voices heard.

https://t.co/1DcuSUss8O

[Sharon Yang @sharonjqyang]

Libbing out in Philadelphia with @KamalaHarris!!!

[Aaron Fritschner @Fritschner]

Two pieces published yesterday