Shelley Sake

Wife, Mom of 3, Vikings, Wild, Twins, UMD hockey fan-Iove me some Minny. Not usually a follower - but I'll make an exception if you are interesting.

[Shelley Sake @shelleysake]

@cutiieepie6 5!

[Shelley Sake @shelleysake]

@krassenstein Diaper

[Shelley Sake @shelleysake]

@Gypsyrwc Destroy the country

[Shelley Sake @shelleysake]

@KhanSaba1278 A

[Shelley Sake @shelleysake]

@Scarletkoito111 A dumpster

[Shelley Sake @shelleysake]

@NBA_NewYork Two good guys in the NBA… Good sports, not floppers. Happy for Kat. Contributed a weekend.

[Spencer Hakimian @SpencerHakimian]

NEW: Trump’s approval rating hits 28%. The lowest for any president in U.S. history.

[CALL TO ACTIVISM @CalltoActivism]

🚨CAUGHT ON TAPE: Mike Johnson PANICS after a recorded conversation is released exposing the House Republican plan to CUT Medicaid, Medicare, AND social security for millions of Americans.

They denied it. The recording just blew up the entire lie. EVERY American should see this.

[Democratic Wins Media @DemocraticWins]

BREAKING: In a stunning admission, Mike Johnson just told reporters that he has plan to cut Medicare and Medicaid after the midterms. We can stop this by making Hakeem Jeffries the next Speaker of the House.

[Shelley Sake @shelleysake]

@itsrosesm Golf

[Shelley Sake @shelleysake]

@Hania16836 Leisure suits- 70’s. I’m gonna guess 74.

[Massimo @Rainmaker1973]

Clinicians described the results as “one of the most amazing things I’ve ever seen.” An experimental once-daily oral drug called daraxonrasib has produced unprecedented outcomes in advanced pancreatic cancer, reducing the risk of death by 60% compared to standard chemotherapy.

In the Phase 3 RASolute 302 trial, daraxonrasib, a RAS(ON) multi-selective inhibitor developed by Revolution Medicines, nearly doubled median overall survival from 6.6–6.7 months with chemotherapy to 13.2 months in patients with previously treated metastatic pancreatic ductal adenocarcinoma. The trial, presented as a plenary session at the 2026 ASCO Annual Meeting, triggered a rare standing ovation from oncology experts.

Unlike traditional therapies, daraxonrasib effectively targets multiple KRAS variants and even wild-type RAS, offering broad applicability to the vast majority of pancreatic cancers. The drug was also far better tolerated, with only 1.2% of patients discontinuing treatment due to side effects, compared to 11.2% in the chemotherapy arm.

This represents a major advance for a disease long considered one of the most lethal in oncology. Experts are hailing daraxonrasib as a potential paradigm shift that could transform metastatic pancreatic cancer into a more manageable condition. The FDA has already granted expanded access for eligible patients.

[O’Reilly, E. M., et al. (2026). Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer. New England Journal of Medicine. DOI: 10.1056/NEJMoa2605555]

[MP Arizona☀️🏳️‍🌈💙🌵🐕🐕‍🦺🫂💦🏜🐟🌴🎙🌎🌻♍️🌊 @AzPetrich]

Friendly reminder: Republicans don't own the 4th of July. They own January the 6th.

[Shelley Sake @shelleysake]

@Suzierizzo1 Satan

[Shelley Sake @shelleysake]

@Hero_OfThe_Day @Centerstrain01 Neither would Anthony Edwards. But, the league protects its golden boys. It’s unwatchable for me.

[Shelley Sake @shelleysake]

@EllenBarkin They cheat- gerrymandering for starters.

[Jamie Bonkiewicz @JamieBonkiewicz]

The IRS is now permanently barred from auditing Trump, his family, and their companies.

What the actual fuck.

[Shelley Sake @shelleysake]

@SAmattyrod @Hero_OfThe_Day @NBA I think goal tending is more their thing

[Shelley Sake @shelleysake]

@Hero_OfThe_Day @NBA This is ruining the sport.

[Shelley Sake @shelleysake]

@Darthgringo420 @JonnyRoot_ Correct.