Keishi Shintomi

Cell biologist exploring how genomic DNA folds into chromosomes by biochemical reconstitution.

[Keishi Shintomi @ShintomiK]

Excited to share our preprint! We rebuilt and dismantled mitotic chromosomes from recombinant proteins, revealing with new assays how condensin I switches on and off during mitosis.
https://t.co/gdnEI1i3bY

[日本分子生物学会 @MBSJ_official]

【#GTC著者コメント #MBSJ】皆さんがよく目にする棒状の染色体は、どのように作られるのでしょうか。染色体が顕微鏡下で初めて観察されてから140年以上経った現在でも、この問いは生物学における重要な未解決課題の一つです。→

[Keishi Shintomi @ShintomiK]

Excited to share our new paper! Using a tunable frog egg extract system, we show that nucleosome density and histone dynamics actively shape mitotic chromosome architecture. https://t.co/0OVQGxR5cO

[Keishi Shintomi @ShintomiK]

@FukayaLab @TakashiAkeraLab おめでとうございます🎉

[ぞえ @sima914masaaki]

初めての筆頭著者論文が @ScienceAdvances に出ました！✨

リンカーヒストンH1が「液体のり」のように働いてクロマチンをダイナミックに凝縮させている！という発見です。

教科書が書き換えられるかも

https://t.co/kZupoKzFrc

続

[Keishi Shintomi @ShintomiK]

A collaborative work is out! Congratulations Marvin, Kiyomitsu-san, and the team.
https://t.co/GLkCkXPx0n

[bioRxiv Molecular Biology @biorxiv_molbio]

CCAN forms the spherical shell-like structure in interphase kinetochores https://t.co/CkmoPmlcx5 #biorxiv_molbio

[Journal of Cell Biology @JCellBiol]

Takao Ono, Tatsuya Hirano et al. @riken_en show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. https://t.co/F37plMYR0c

#CellCycle

[名古屋大学菅島臨海実験所 NU-MBL @nu_mbl]

数年前に菅島で採取した黒色酵母はとても興味深く、栄養に応じて単細胞と多細胞の姿を切り換えます。その切り換えに必要な遺伝子を見つけました。多細胞生物の進化について示唆を与えてくれます。論文はNature誌に掲載されました。
https://t.co/dBzoRupYJ5

[Tatsuo Fukagawa @tatsuofukagawa1]

Our new paper was just out. CRISPR screening with a CENP-C mutant reveals that KIF18A and CENP-E are coordinately involved in chromosome congression. Congrats, Jiahang Miao!!

https://t.co/iw2mVVuQa0

[Andreas Boland @BolandLab_GE]

How is timely and accurate sister chromatid separation achieved?

A process that is happening around 30-50 billion times per minute!!! in the human body needs tight regulation (to avoid cancer development...).

paper:
https://t.co/X0uF42A06a

comment:
https://t.co/8inOxfGlve

[理化学研究所（理研） @RIKEN_JP]

老化卵子の染色体数異常を抑止することに成功
－人工動原体による「おとり戦略」の発見－

doi: https://t.co/MyUORAxSk0

詳細はこちらをご覧ください⬇️
https://t.co/PuUHqYAwst

#理研プレス

[Science in Seattle @science_seattle]

🐸 Ever wonder how frogs help solve cancer mysteries?

At @fredhutch, Dr. Yasuhiro Arimura (@ArmrYshr) is using frog-egg extracts to understand chromatin like never before, revealing structures that could unlock new insights into cancer and cell division: https://t.co/yC0MTkfA0h

[国立遺伝学研究所 @NIG_idenken]

【研究成果】自分の細胞に光合成する生物を宿して生きる「光共生」。宿主のミドリゾウリムシと内部のクロレラを調べると、栄養が全くない環境でも、細胞内で栄養を再利用する「循環農業」で生き延びていました。光合成と捕食を細胞内で融合させた「生きる閉鎖型循環系」で���。https://t.co/EYeD5nrtfX

[Molecular Cell @MolecularCell]

Online Now: Cryo-EM reveals open and closed Asgard chromatin assemblies https://t.co/XU9Adt3kGh

[理化学研究所（理研） @RIKEN_JP]

世代を超えてテロメアDNAを維持する新たな仕組み
－線虫テロメレースRNAによる「イントロン・ヒッチハイク」－

doi: https://t.co/yWyxFspyc0

詳細はこちらをご覧ください⬇️
https://t.co/yb43zGcCHj

#理研プレス

[Journal of Cell Biology @JCellBiol]

Ivan Avilov, Peter Lenart @LenartLab et al. used quantitative phosphoproteomics in #starfish #oocytes to identify downstream targets of the conserved Mos–MAPK pathway. https://t.co/ppABGDPmIa

#Cytoskeleton #CellCycle #CellDivision #Physiology

[NatureStructMolBiol @NatureSMB]

New online! Structure and activation mechanism of a Lamassu phage and plasmid defense system https://t.co/O5xAiEz2KD

[Prof. Feynman @ProfFeynman]

Intelligence isn't the ability to remember and repeat, like they teach you in school. It is the ability to learn from experience, solve problems, and use our knowledge to adapt to new situations.

[Dr. Nicolas L. Young @NicolasLYoung]

Today, we introduce a nomenclature that can express discrete PTMs, proteoforms, nucleoforms, or situations where defined PTMs exist in an uncertain context and can describe how proteoforms are configured in functionally distinct complexes across biology. https://t.co/WrMYTXamIe

[Keishi Shintomi @ShintomiK]

@HokkaidoUnivPR コンデンシンはリンカーヒストンと競合してヘテロなDNA構造を形成する | 理化学研究所 https://t.co/Nd2oPja0OD