Eli Lilly just released Phase 3 data for retatrutide, their next-generation obesity drug. 2,339 patients. 80 weeks. The biggest trial in the field.
8 things worth knowing:
1️⃣ It beats every obesity drug on the market. Wegovy (semaglutide): 15% Zepbound (tirzepatide): 22% Retatrutide: 25%
2️⃣ You don’t need the highest dose. The lowest (4mg) already outperforms Wegovy. 18% weight loss with one dose increase. Fewer people quit than on the sugar pill.
3️⃣ At two years, weight was still dropping. No plateau. Patients with BMI over 35 lost 84 pounds. 30% of their body weight.
4️⃣ Some patients stopped taking it because they lost too much weight. That’s never happened with an obesity drug.
5️⃣ It works differently. Ozempic and Zepbound suppress appetite. Retatrutide does that too, but its third receptor (glucagon) flips your metabolism toward burning stored fat. In Phase 2, ketone bodies rose 2-3x, confirming the body was switching fuel sources.
6️⃣ It causes a side effect no other obesity drug does: tingling and numbness (12.5%). New receptor, new trade-off. Worth watching.
7️⃣ In a separate study, it cleared 86% of liver fat. 93% of patients reached normal levels. 1 in 3 adults have fatty liver disease. No approved drug comes close.
8️⃣ Two-thirds of patients on the highest dose were reclassified out of obesity entirely. They started at BMI 40. They finished under 30. That’s not just weight loss. That’s a medical reclassification.
@US_FDA filing expected late 2026.
A community college professor named Marty Lobdell taught the same study skills lecture for 30 years. The video quietly became one of the most watched educational recordings online, with over 10 million views.
He spent his career watching students fail not because they were lazy, but because no one had taught them how their brain actually works when learning something difficult.
The lecture, “Study Less Study Smart,” contains a powerful framework.
Your brain cannot sustain focus the way most people believe. Studies show the average learner hits a wall between 25 and 30 minutes. After that, efficiency collapses. You’re still sitting there, but almost nothing is being absorbed.
Lobdell told the story of a student who planned to study 6 hours a night, 5 nights a week. Thirty hours total. She failed every class. She was not lacking effort. She was confusing time near books with actual learning. The fix is simple: when focus drops, stop, take a 5 minute rewarding break, then return. That reset makes a massive difference.
He also destroyed the myth of highlighting and re reading. Recognition is not the same as recall. To prove it, he read 13 random letters. Almost no one remembered them. Then he turned them into “Happy Thursday.” The entire room recalled them instantly. The brain stores meaning, not repetition.
This is why elaborative encoding works so well.
Finally, he shared the most important principle: 80 percent of study time should be active recitation. Close the book and explain the material in your own words. Teach it to someone else or an empty chair. Retrieval is where real learning happens.
His closing line stuck with me: If this information does not change your
behaviour, you have not actually learned it.
The best students do not study more hours. They stop confusing the feeling of studying with the reality of learning.
"You Get What You Give" is basically a solo project disguised as a band. Gregg Alexander (vocalist, songwriter and producer) recorded almost the entire album Maybe You've Been Brainwashed Too (1998) alone, playing most of the instruments and doing all the lead vocals. The track became the band's only major hit. The famous ending of the track ("Beck, Hanson, Courtney Love and Marilyn Manson / You're all fakes...") It caused controversy at the time, because several artists mentioned were pissed off, but Gregg said it was only to criticize the fame industry and materialism. After the success, he dissolved the New Radicals and disappeared from the stage forever, becoming a backstage composer (he wrote tracks for Ronan Keating, Danielle Brisebois...).
The Anabaptist Kingdom of Münster stands as history's most vivid demonstration that collectivism breeds tyranny and starvation centuries before Marx penned a single word about class struggle.
In 1534, radical Anabaptist preachers seized control of this German city and immediately declared their "New Jerusalem" built on complete communal ownership. Private property vanished overnight. The new regime confiscated all money and demanded citizens pool every resource for the collective good. Sound familiar?
The self-proclaimed "Tailor-King" Jan van Leiden ruled this proto-socialist paradise with absolute authority, enforcing his vision of equality through systematic terror. Dissenters faced immediate execution. The state mandated polygamy as official policy while abolishing individual economic choice entirely.
When you destroy price signals and property rights, you destroy the coordination mechanism that feeds cities. Münster's collectivist experiment delivered exactly what economic theory predicts: rapid collapse into famine and chaos. Within months, residents ate rats and boiled leather to survive. Reports of cannibalism emerged as the egalitarian dream transformed into a living nightmare.
The most predictable element? Elite hypocrisy. While ordinary citizens starved in their enforced equality, van Leiden and his inner circle lived in luxury, enjoying the finest food and accommodations the collective could provide. Centralized power inevitably corrupts those who wield it.
The economic logic remains bulletproof: without private property, individuals lose incentive to produce efficiently. Without market prices, planners cannot calculate resource allocation. Without voluntary exchange, coercion becomes the only tool for organizing complex society. Münster's rulers discovered these iron laws the hard way.
The starving city collapsed from within as its communist economy proved incapable of sustaining basic human life. When Catholic armies finally retook Münster in 1535, they found a wasteland of economic destruction and human misery.
The victors tortured the surviving Anabaptist leaders and displayed their bodies in iron cages hung from the city's main church. Those cages remained there for centuries as a warning about utopian schemes that promise equality but deliver only death.
Modern advocates of wealth redistribution and collective ownership prefer to ignore Münster's lessons. They insist their version of centralized control will somehow escape the economic laws that doomed every previous attempt. But human nature and market forces operate independently of ideological wishes.
The Anabaptist experiment reveals the fatal flaw in all collectivist thinking: the assumption that abolishing property rights creates abundance rather than scarcity. In reality, property rights exist because they solve the fundamental problem of resource allocation in a world of competing needs and limited goods.
Münster's collapse took just sixteen months to complete. The city's descent from Protestant reform to communist tyranny to economic wasteland offers a perfect case study in how quickly good intentions can destroy functioning societies when they ignore basic economic principles.
You can find those iron cages in Münster today, still hanging from St. Lambert's Church after nearly five centuries. They serve as permanent reminders that collectivism's promises always end the same way: in starvation, tyranny, and death.
@DebaerePieter Vriend heeft de dure versie en is super enthousiast. Heeft zijn gym (kracht training) al aangepast en zelfs zijn drinken/op stap gaan. Heel tevreden met het inzicht en details. Heb link via hem voor korting.
@SteviesQuotes Agree to disagree. Echt onhygiënisch al die shorten, en dan zelf nog eens gasten met onderbroeken onder die shorten. Bah. Geef mij maar strakke slips of boxers.
Your visual cortex burns 44% of your brain's energy budget. Turning off the lights in the shower is the fastest way to slash that load to near zero.
Your brain is 2% of your body weight but burns 20% of your total energy. Visual processing alone eats almost half of that. Every photon hitting your retina triggers a cascade of neural signaling that demands oxygen, glucose, and ATP at rates higher than almost any other cognitive function.
When you kill the lights, you're removing the single largest energy load on your cortex. That freed-up metabolic capacity gets reallocated.
This is where it gets interesting. A 2022 study from the Laureate Institute for Brain Research measured what happens when you strip sensory input from anxious patients. High-frequency heart rate variability, the gold standard marker of parasympathetic activation, increased significantly compared to controls. Blood pressure dropped. Breathing rate fell. The nervous system shifted from sympathetic dominance to parasympathetic mode within minutes.
The warm water adds a second mechanism. Core body temperature rises during the shower. When you step out, temperature drops rapidly. That cooling signal triggers melatonin production and primes the circadian system for sleep. Layer darkness on top: no photons suppressing melatonin through the retinal ganglion cells, no blue-light signaling to the suprachiasmatic nucleus that it's still daytime.
The shower is doing three things simultaneously. Reducing cortical energy demand by eliminating visual input. Activating the parasympathetic nervous system through sensory reduction. Triggering thermoregulatory sleep signaling through the heat-then-cool cycle.
A $0 float tank that takes 10 minutes.
The '14 Eyes Alliance' & What it Means For VPN Users
These 14 countries share mass surveillance data:
🇺🇸US, 🇬🇧UK, 🇨🇦Canada, 🇦🇺Australia, 🇳🇿NZ , 🇩🇰Denmark, 🇫🇷 France, 🇳🇱Netherlands, 🇳🇴Norway , 🇩🇪Germany, 🇧🇪Belgium, 🇮🇹Italy, 🇪🇸Spain, 🇸🇪Sweden.
If your VPN provider is based in any of these countries, the local government can legally force them to start logging your data & share it with all the others.
Generally, the better move is to choose a no-logs VPN headquartered outside the 14 Eyes (i.e. Switzerland, Panama,...).
After being rescued from a petting zoo, a special camel had trouble fitting in with the other animals on the rescue farm. It wanted nothing more than to be friends with all the horses and alpacas, but they had never seen a camel before. After a while, they realized that it was just a funny version of them, so they began to warm up to it, and now it has become part of the herd ✨💖
Was de staat maar straat.
Dan kon ik nog gewoon terugvechten.
Vroegâh had je nog het idee dat de overheid er voor je was om dingen te regelen. Dat ze aan onze kant stond. De wegen zijn toen voor ons, met ons belastinggeld, aangelegd. De veiligheid was redelijk en je kon zelf nog wat zaken regelen, samen met oom agent als er iets fout ging. Er was nog sprake van redelijke scholing. Kinderen van 6 kunnen tegenwoordig niet eens hun veters strikken.
Je betaalde belasting en kreeg er iets voor terug. Of je had in ieder geval het idee dat je je belastingcenten direct voor je aan het werk zag. En er was een menselijke maat.
Dat idee is niet meer.
Stap je in je auto, dan begint het ontwijken van extra kosten. Niet rijden, maar opletten. Flitser hier, trajectcontrole daar, speciale camera’s om te kijken of je telefoneert of je je gordel om hebt. 30 km hier, tijdelijke omleiding met controle daar. Niet te doen. En het gaat maar door.
Niet omdat het veilig is, maar omdat de staat je geld nodig heeft. Ze kan niet zonder. Wat ze ook gewoon schaamteloos toegeven. En wij schijnen er ook nog voor gestemd te hebben.
Ondertussen is er wegenbelasting, BPM, accijns op brandstof, en dan nog parkeerkosten waar je stijl van achterover slaat. In Rotterdam tik je rustig meer dan 80 euro per dag af om je auto ergens neer te zetten.
https://t.co/DAG8dhinxw
Je bent geen weggebruiker meer. Je bent, naast belastingbetaler, de slaaf in de boot die zweepslagen krijgt om harder te roeien, omdat de kapitein de weg kwijt is.
Ga je tanken, dan voel je het al voordat je überhaupt begint. Niet alleen de prijs van benzine of diesel, maar vooral de belasting die erbovenop zit. Alles is opgetuigd om jou te laten betalen. En nog eens betalen. En het liefst nog een keer, omdat ze denken dat je het toch wel pikt.
Dan de supermarkt. Je loopt naar binnen voor een paar simpele dingen en staat buiten alsof je een luxe vakantie hebt geboekt. Nederland is inmiddels de koploper in Europa als het gaat om hoge voedselprijzen. Huishoudens betalen structureel meer, en dat blijft zo.
https://t.co/kdgfCboU0s
Koffie twintig procent duurder. Vlees dat door het dak gaat. Boter, cacao, kaas, alles omhoog. Inflatie 3,3%? Ammehoela. Eerder 20.
https://t.co/UgbJwjipkE
Kom je thuis, ligt er weer zo’n blauwe envelop. Belastingen, heffingen, vrijheidsbijdragen. Nieuwe woorden voor hetzelfde verhaal: betalen. Altijd betalen. En nog een keer betalen. De overheid verzint er zelfs nieuwe namen voor. Vrijheidsbijdrage, klimaatheffing, gemeentelijke lasten.
Vrijheid is iets wat geld kost.
Ondertussen stijgen je vaste lasten. Huur omhoog, energie omhoog, alles omhoog. Inflatie zit al jaren boven wat “gezond” zou moeten zijn en wordt gebagatelliseerd in de media om je rustig te houden. Het raakt vooral de mensen die het toch al moeilijk hebben.
https://t.co/xFwzSjBAce
Wat krijgen we ervoor terug?
Een overheid die zich echt overal mee bemoeit en niks oplost. Regels, controles, systemen, boetes. Alles dichtgetimmerd. Alles gemonitord. Alles belast.
De staat als vangnet? Vergeet het maar. De staat is een machine geworden.
Een machine die je alleen wil hebben voor je geld. Niet om ons leven beter te maken, maar om zichzelf draaiende te houden.
En we doen alsof het normaal is.
Dit is niet normaal.
En hoe langer we dat niet hardop zeggen, hoe verder het doorslaat. Want wanneer was de laatste keer dat jij dacht
de overheid staat echt aan mijn kant?
Disclaimert:
Ik heb geen gofundme of donatie button. Als je het eens (of oneens) bent met wat ik schrijf, reageer vooral of kom een tattoo of piercing bij me halen. Dan hebben we er gelijk een goed gesprek over. Ik sta altijd open voor ieders mening.
En teken mijn petitie: https://t.co/DHhx0MCaAH