SIRIC - SOCRATE 2.0

[Cancer Cell @Cancer_Cell]

Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy https://t.co/t5wI9xFwcN

[FabriceAndre @FAndreMD]

Life histories of myeloproliferative neoplasms: « Driver mutations were estimated to occur early in life, including the in utero period ». Many papers now assess the impact of mutations and/or risk factors that occur early in the life https://t.co/qIAuuzukfk

[Nature Reviews Drug Discovery @NatRevDrugDisc]

Disruptions in the development of cell and gene therapies https://t.co/mF57iT2cdJ This new analysis indicates that 43% of cell and gene therapies had a disruption during development in 2016-2021, with CMC issues being a key cause that is more common than for monoclonal antibodies

[Nature Portfolio @NaturePortfolio]

A paper in @Nature describes a methodology to score dynamic leukocyte behavior and activation states by multiplex analysis of migration parameters in four different models of acute inflammation. https://t.co/PQqzfC6aZa

[Nature Reviews Drug Discovery @NatRevDrugDisc]

For readers interested in the past decade of development of PD1/PD1 immune checkpoint inhibitors, here's a comprehensive article from pioneers in the field https://t.co/Fmfx8WBiPA

[FabriceAndre @FAndreMD]

The Unit of Informatics of @GustaveRoussy in 1973 ! There is a detail on one picture that would never appear nowadays in a pic of Hospital 😅 can some find it ? Pic 3 looks like a Science Fiction movie 🎥 of the 50’s !

[Nature Reviews Drug Discovery @NatRevDrugDisc]

2021 FDA approvals https://t.co/qvpCLdacru The FDA approved 50 novel drugs in 2021, keeping up the level of recent years. Find out more about the trends and highlights, such as the first KRAS inhibitor for cancer, in this annual roundup by @AsherMullard

[LUKMAN AFOLABI @saintlukman]

Engineering synthetic RNA devices for cell control https://t.co/hb3MokJ5h7

[Jake Yeston @JakeYeston]

We don’t often put small molecules on the cover of @ScienceMagazine but the paxlovid development story (handled with inspiring acumen by @ValdaVinson) is medchem at its sterling best. Congrats and thanks to the whole Pfizer team on their exceptional work! https://t.co/B8cQSp48FG

[FabriceAndre @FAndreMD]

Thank you @NatureCancer for highlighting LAG3, the 3rd immune checkpoint validated as therapeutic target in cancer. LAG3 was discovered @GustaveRoussy by F Triebel & T Hercend

[FabriceAndre @FAndreMD]

Tks to RHU call, 4 precision medicine projects of @GustaveRoussy & @UnivParisSaclay will be launched (36 M euros). These projects will develop new technologies to improve pt outcome: AI&RT, ctDNA, microbiota, organoids.
🇫🇷 proposes v attractive grants. Join us if you have a proj

[Nature Biotechnology @NatureBiotech]

Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning https://t.co/hE2IuZiGB4

[NatureRevClinOncol @NatRevClinOncol]

Organoid/T cell co-culture screen reveals that the epigenetic inhibitors GSK-LSD1, CUDC-101 and BML-210 have antitumour activities via upregulation of antigen presentation mediated by the MHC I on #breastcancer cells, & thus synergize with PD-1 inhibitors: https://t.co/fH7JbyO7lT

[Eric Topol @EricTopol]

Just out @SciImmunology Good news on the long-lasting T cell response to a mRNA vaccine, with a sizable T stem cell memory population
https://t.co/a9Xg3co3nb

[SIRIC - SOCRATE 2.0 @siric_socrate]

A new way to monitor #ctDNA in #cancer #screening and #progression ???

[Science Magazine @ScienceMagazine]

New research from @ScienceTM reveals that #RedBloodCells help activate the innate immune response to #sepsis and viral pneumonia in patients—a finding that contradicts the established view of these cells as immunologically inert. https://t.co/JZu9LuCPJ1

[Nature Biotechnology @NatureBiotech]

Improved prediction of immune checkpoint blockade efficacy across multiple cancer types https://t.co/wPmKSGMw1P

[Nature Biotechnology @NatureBiotech]

Scientists are using new tools to mine the non-coding part of the genome, known as ‘dark matter’, to uncover disease-linked changes in promoters, silencers and enhancers for target discovery https://t.co/GwNWPYe2N0

[Nature Biotechnology @NatureBiotech]

Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer https://t.co/yiecuBOzRC

[SIRIC - SOCRATE 2.0 @siric_socrate]

#CRISPR #screens are nowadays instrumental to identify #genes accountable for cold/hot #tumor #microenvironment. This CELL paper will give you a glimpse of the power of this technology while providing great perspectives for #immunotherapy of TNBreastCancer https://t.co/NHmr89kfqv

[Eric Deutsch @Edradonc]

And that's a wrap! To all our organizers, speakers, sponsors & participants, THANK YOU for making the #ImmunoRad21 Conference in Paris a huge success! See you next year in New York! Sept 22-24, 2022 #radonc #immunology #radiotherapy #oncology