Benjie Smith

MD/PhD student at Stanford. Glycobiology. Immunology. Chemistry. Radiology.

[Kelvin Anggara @vixklen]

Out today in @ScienceMagazine: Seeing glycans attached to proteins and lipids - at the *single molecule level*! 🎉🎉🎉

https://t.co/H2110fWY6m
#ScienceResearch #glycotime #teammassspec

My 1st #tweetorial🧵(1/n) 👇👇👇

[Binbin Chen @DrBinSquared]

Excited to share our work on TAPIR, a generalizable ML model that can predict TCR-target interaction!

T-cell receptors (TCRs) are involved in most diseases, but linking their sequences with targets is an unsolved grand challenge in the field.

https://t.co/TYLO873Flx

[Benjie Smith @smithbenjie]

As simple as ABCD - Autoimmune central B12 deficiency: autoantibodies vs transcobalamin receptor cause depletion of B12 in the CSF with typical s/sx of B12 deficiency in patients with normal serum B12

[Benjie Smith @smithbenjie]

You don’t see a paper like this every day - discovery of a new disease, guided by a peculiar patient story, complete with molecular characterization:
https://t.co/FHcxJs4mEM
This is what translational research should look like. @jvpluv strikes again

[Benjie Smith @smithbenjie]

@StacyMalaker Maybe a heat map?

[Benjie Smith @smithbenjie]

It was an honor to have you hood me x2 and learn from you during my PhD @CarolynBertozzi. Your commencement speech was fantastic, complete with wisdom from your own experience and the infamous Walter White!

[Majzner_Lab @Majzner_Lab]

Happy to share the newest paper from our lab. Led by technician extraordinaire Aidan Tousley (soon to be an MD/PHD student!), this manuscript details our attempts to reimagine the structure of CARs to improve their specificity and efficacy. https://t.co/EKzcX4JaFP

[Benjie Smith @smithbenjie]

Woke up to incredible news this morning. Congratulations @CarolynBertozzi!!

[The Nobel Prize @NobelPrize]

BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”

[Benjie Smith @smithbenjie]

A beautiful piece on dealing with death and loss by @tpjmd “Shared presence - really being there with and for each other - at a moment of loss can sanctify sorrow. Some alchemy can wring from the stone of shared suffering something like love.” https://t.co/0Ga1OIzrMN

[Majzner_Lab @Majzner_Lab]

My lab at Stanford is hiring. We work on engineering new cancer immunotherapies and understanding their activity in early phase trials. Open postdoc positions as well as a technician with animal experience. Contact me if interested! Please retweet!

[Majzner_Lab @Majzner_Lab]

Happy to share our lab's first manuscript. In work led by @JTheruvath_MD, we tested a combo of FDA approved anti-GD2 with blockade of CD47, a macrophage checkpoint. Blocking CD47 unleashes patients' macrophages to phagocytose or 'eat' cancer cells. Combo was highly effective! 1/

[Benjie Smith @smithbenjie]

A new dimension to CD22 in humans! Stimulating work by @jvpluv

[John Pluvinage @jvpluv]

Excited to share our new paper in @ScienceTM where we find an oligodendrocyte derived protein in CSF impairs microglial lysosome function https://t.co/kWxLDzzykY

[Benjie Smith @smithbenjie]

@gungulati @BrighamMedRes Congrats! Super excited for you!!

[Hiren Joshi @hirenj]

If anyone out there is doing glyco work with Illustrator, I have something for you! It’s a library of glycans for dropping into whatever you’re working on, as well as the SNFG colour palette. If you follow the lib, you can get updates as I make them!

https://t.co/RgsBXT58Rk

[Benjie Smith @smithbenjie]

"Importantly, while screening multiple mice in parallel increases the power to discover significant hits, a single mouse is sufficient to identify significantly enriched and depleted genes."

[Kristin Knouse @kristinknouse]

We are thrilled to share our development of genome-wide CRISPR screening within a living mouse! Our approach is accessible to diverse phenotypes and we look forward to the many insights now achievable with high-throughput functional genomics in an organ! https://t.co/ffdMfERvbY

[Benjie Smith @smithbenjie]

@CarolynBertozzi @CyrialDilutions @NatRevDrugDisc Great catch, thank you!

[Stacy Malaker @StacyMalaker]

Calling all #glycotime fanatics! I'd like to introduce you to the #mucinome! We can now selectively enrich proteins that have mucin domains, and we developed a mucin candidacy algorithm (@riley_nm1) to assign confidence to our hits. @CarolynBertozzi 🧵👇https://t.co/eFSvr8MtBL

[Benjie Smith @smithbenjie]

It's 2021 and cultures, which take weeks, are still the gold standard for TB diagnosis. This is another step toward solvatochromatic probes becoming the standard of care @mkamariza2002 and @Peyton_Shieh

[Mireille Kamariza @MireilleKamariz]

Show stopper: these are TB-causing cells detected with our #DMN-Tre probe in ***blood samples*** - a first!

The paper is in the works and stay tuned for the preprint.

Pic credit: @davidadambarr from @graemein lab.

#StopTB #SmartProbes #TBDx

[Benjie Smith @smithbenjie]

@CarolynBertozzi and I reviewed the landscape of therapies targeting mammalian #glycans, #siglecs and #selectins, focusing on discoveries that launched new drug development campaigns, lessons learned, and promising candidates to watch. Keep your eye on the #glycotime pipeline!

[Nature Reviews Drug Discovery @NatRevDrugDisc]

The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans https://t.co/D1tPsVANyV - this new review by Benjamin Smith and @CarolynBertozzi highlights experience and therapeutic opportunities in a field that is becoming increasingly tractable

[Benjie Smith @smithbenjie]

Congrats @KayvonPedram, excited to see what you work on next!