Shedding light on the structure-function mechanisms of LRR-RPs. Our research merges #AlphaFold3, years of literature and functional validation to reveal diverse ligand-binding mechanisms and a conserved co-receptor association mechanism. https://t.co/aCb5PEMMg1
We proudly present: Tomatoes have MIK2, too: However, it does not sense SCOOP peptides but a Fusarium elicitor. Thanks to all collaborators for the support.
https://t.co/4sPrghQZmW
Plant pattern recognition receptors: from evolutionary insight to engineering https://t.co/pyr5fL2Yys #Review by @snoeck_simon, Oliver Johanndrees, @ThorstenNrnber1 & Cyril Zipfel
Free to read here: https://t.co/71I7KTR3yJ
In @NatureRevGenet: "Plant pattern recognition receptors: from evolutionary insight to engineering" https://t.co/quEf5PJzIy
...summarizes both established and innovative approaches to () translate resulting evolutionary insights into engineering PRR recognition specificities.
Intriguing role for N-glycosylation in LRR-RK activation: https://t.co/A37M9tdbcL and https://t.co/YhAZGKC6sD.
Glad to see that cryo-EM and crystallography pinpoint the same ligand binding pockets as AF:
https://t.co/qQcGfJnG6q
Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against ... https://t.co/MVlRyrJoYx #biorxiv_plants
Ten days left to apply! We will try to make a new generation of selective pesticides based on the natural defense system in plants. #ERC_research#plantscijobs#postdoc#academicjobs. Thx for RT last time, feel free to RT again or notify people that might be interested! 🙏
"Leveraging co-evolutionary insights and AI-based structural modeling to unravel receptor-peptide ligand-binding mechanisms". We identified 2 MIK2 binding pockets which interact with the conserved SxS SCOOP motif in a relatively quick and inexpensive way. https://t.co/QhIbNSEO9M
New review preprint w @snoeck_simon @anthonygkgarcia
Plant Receptor-like proteins (RLPs): Structural features enabling versatile immune recognition
We analyze RLPs in light of the exciting new RXEG1 structure. Your feedback would be really appreciated!
https://t.co/3BWaSmNL34
I joined the recently established lab of @ADSteinbrenner 3 years ago, to this day exactly. I guess this is a proper way to celebrate our anniversary? ;) Thanks for the opportunity Adam, I had a blast with this one!!
Our paper with work by @snoeck_simon and @anthonygkgarcia is out today in @eLife !
We describe the evolution of herbivore peptide recognition by a plant immune receptor, and resurrect the sequence of the ancestral gene from ~28 million years ago.
https://t.co/yCfN8chnAP
Last time flying back "home" to Seattle. Glad I got the opportunity to visit both SLU and UZH. Excited to start a new chapter in 2023. Also, both places have affordable and great bakeries :)