Simon Snoeck

Postdoctoral researcher, Cyril Zipfel's group (IPMB, University of Zurich),
Latest story:

[bioRxiv Plant Bio @biorxiv_plants]

Disulfide bond sculpts a peptide fold that mediates phytocytokine recognition https://t.co/hMLN29nTTM #biorxiv_plants

[Simon Snoeck @snoeck_simon]

Shedding light on the structure-function mechanisms of LRR-RPs. Our research merges #AlphaFold3, years of literature and functional validation to reveal diverse ligand-binding mechanisms and a conserved co-receptor association mechanism. https://t.co/aCb5PEMMg1

[Ralph Hückelhoven @HuckelhovenR]

We proudly present: Tomatoes have MIK2, too: However, it does not sense SCOOP peptides but a Fusarium elicitor. Thanks to all collaborators for the support.

https://t.co/4sPrghQZmW

[Jack Rhodes @JWR_nhf]

Are you interested in receptor kinase signalling and plant immunity? We have several positions open to join our team at
@TheSainsburyLab in Norwich.
#plantscience
#mpmi
#plantimmunity
#sciencejobs
Please get in touch if you have questions

[Nature Reviews Genetics @NatureRevGenet]

Plant pattern recognition receptors: from evolutionary insight to engineering https://t.co/pyr5fL2Yys #Review by @snoeck_simon, Oliver Johanndrees, @ThorstenNrnber1 & Cyril Zipfel
Free to read here: https://t.co/71I7KTR3yJ

[Nature Plants @NaturePlants]

In @NatureRevGenet: "Plant pattern recognition receptors: from evolutionary insight to engineering" https://t.co/quEf5PJzIy

...summarizes both established and innovative approaches to () translate resulting evolutionary insights into engineering PRR recognition specificities.

[Simon Snoeck @snoeck_simon]

Intriguing role for N-glycosylation in LRR-RK activation: https://t.co/A37M9tdbcL and https://t.co/YhAZGKC6sD.
Glad to see that cryo-EM and crystallography pinpoint the same ligand binding pockets as AF:
https://t.co/qQcGfJnG6q

[bioRxiv Plant Bio @biorxiv_plants]

Reverse engineering of the pattern recognition receptor FLS2 reveals key design principles of broader recognition spectra against ... https://t.co/MVlRyrJoYx #biorxiv_plants

[Simon Snoeck @snoeck_simon]

*now with AF3/cherry on the cake

[Simon Snoeck @snoeck_simon]

Leveraging CZL, coevolutionary insights and AI-based structural modeling to unravel receptor–peptide ligand-binding mechanisms | PNAS https://t.co/mhNibWYFFT

[Simon Snoeck @snoeck_simon]

@Phil_Carella Thanks Philip!!

[Simon Stael @SimonStael]

Ten days left to apply! We will try to make a new generation of selective pesticides based on the natural defense system in plants. #ERC_research #plantscijobs #postdoc #academicjobs. Thx for RT last time, feel free to RT again or notify people that might be interested! 🙏

[Simon Snoeck @snoeck_simon]

"Leveraging co-evolutionary insights and AI-based structural modeling to unravel receptor-peptide ligand-binding mechanisms". We identified 2 MIK2 binding pockets which interact with the conserved SxS SCOOP motif in a relatively quick and inexpensive way. https://t.co/QhIbNSEO9M

[Nick Wybouw @NWybouw]

One week left to apply for this postdoc position!

[Simon Snoeck @snoeck_simon]

It felt like a good time to write down some accumulated insights on RLPs. Basically, the guide I wish I had when I started studying them 3years ago.

[Adam Steinbrenner @ADSteinbrenner]

New review preprint w @snoeck_simon @anthonygkgarcia

Plant Receptor-like proteins (RLPs): Structural features enabling versatile immune recognition

We analyze RLPs in light of the exciting new RXEG1 structure. Your feedback would be really appreciated!
https://t.co/3BWaSmNL34

[Simon Snoeck @snoeck_simon]

I joined the recently established lab of @ADSteinbrenner 3 years ago, to this day exactly. I guess this is a proper way to celebrate our anniversary? ;) Thanks for the opportunity Adam, I had a blast with this one!!

[Adam Steinbrenner @ADSteinbrenner]

Our paper with work by @snoeck_simon and @anthonygkgarcia is out today in @eLife !

We describe the evolution of herbivore peptide recognition by a plant immune receptor, and resurrect the sequence of the ancestral gene from ~28 million years ago.

https://t.co/yCfN8chnAP

[Simon Snoeck @snoeck_simon]

@SimonStael Thanks for hosting me Simon, really appreciated.

[Simon Snoeck @snoeck_simon]

Last time flying back "home" to Seattle. Glad I got the opportunity to visit both SLU and UZH. Excited to start a new chapter in 2023. Also, both places have affordable and great bakeries :)

[Simon Snoeck @snoeck_simon]

@JWR_nhf Thanks Jack, just made it back. It was a pleasure to meet you, and that counts for all 3 cities ;)

[Simon Snoeck @snoeck_simon]

One to remember, so glad I got the opportunity to join and share my work after three years of talking to my computer.

[Melinka Butenko @MelinkaAlonso]

#PPRM2022