Happy&Healthy

Amante de la Vida, Mujer, madre, esposa y amiga... vivo saludable, vivo intensa, vivo feliz... con altos y bajos pero Feliz!!

[Happy&Healthy @solitasantander]

https://t.co/gxtrweYswR

[Quasi-ModoⒶ @QuasiDixit]

7. CONSPIRACIONES QUE RESULTARON CIERTAS

En 1971 se jubilaba el doctor John Yudkin, desacreditado y ridiculizado por la comunidad científica.
Yudkin había publicado en 1957 un estudio que demostraba que el AZÚCAR era un PELIGRO para la SALUD:
Acababa de arruinar su reputación⬇️

[Happy&Healthy @solitasantander]

https://t.co/R8RMcXLKq1

[Happy&Healthy @solitasantander]

https://t.co/Ar5CPFJJMH

[Happy&Healthy @solitasantander]

https://t.co/ZqVPKcRPtB

[Sociedad SEEN @sociedadSEEN]

🆕 Actualización #ManualSEEN 👉 "Cirugía bariátrica metabólica"

Por los Dres. Coral Montalbán Carrasco, Ricardo Batanero Maguregui y Luis Alberto Vázquez Salvi.

Echa un 👁️ https://t.co/dRzXu637oy

[Happy&Healthy @solitasantander]

PRÓXIMO EVENTO #ZUMBA en Peñalolén invitados internacionales #BROTHERSTWINZ

RESERVA TU ENTRADA CONMIGO EN INSTAGRAM AL DM @SOLZIN21

[Dave Feldman @realDaveFeldman]

🚨🚨🚨🚨🚨🚨🚨🚨
BREAKING: FIRST PUBLICATION NOW AVAILABLE —> https://t.co/AJzp1wuoM4

KETO-CTA (#LMHRstudy) vs Control (#MiHeart)
-🙏Please Share! 🙏-

METHODS – 80 Participants of #LMHRstudy fell within #MiHeart age range and were then matched 1:1 for age, gender, race, diabetes mellitus, hyperlipidemia, hypertension, and past smoking to asymptomatic subjects from the #MiHeart cohort.

PRIMARY ANALYSIS – High resolution heart scans (#CCTA) allowing for primary analysis of Total Plaque Score (TPS), Total Stenosis Score (TSS) and Segment Involvement Score (SIS)

RESULTS
The matched mean age was 55.5 years, with mean #LDL cholesterol of 272 mg/dL (max LDL-C 591) mg/dl and mean 4.7 years duration on a ketogenic diet.

🚨 There was no significant difference in coronary plaque burden of #LMHRstudy (mean LDL-C 272) cohort as compared to #MiHeart controls (mean LDL 123 mg/dl); nb: pre-KETO LDL-C in KETO group was 122 mg/dl

🚨 There was no significant difference in CAC (median and IQR) [0 (0,56)] versus [1 (0, 49)], p = 0.520

🚨 No relationship of LDL-C elevations and plaque

⚠️ NOTE: This analysis is on baseline scans, we will have further data on the Keto-CTA longitudinal analysis in the coming months. And — as always — please continue to work with your doctor.

🙏🙏🙏 Special thanks to everyone who got us to this first publication milestone. 🙏🙏🙏

Extra shout out to @nicknorwitz @DrRagnar @AdrianSotoMota @khurramn1 and, ofc, @BudoffMd

And a MASSIVE thanks to everyone who has contributed their money, time, and/or sharing to help us spread the word and make this research a reality!

(PS — this is unfortunately not Open Access as this wasn’t an option we had available for us — but the full manuscript will be published soon as a separate paper and *will* be open access)

[Happy&Healthy @solitasantander]

Experimentos N=1 ref. Lipid energy model

[Nick Norwitz MD PhD @nicknorwitz]

🚨#OreoVsStatin - PUBLISHED!🚨
https://t.co/3Ap9zKn3XJ

@Oreo cookies were 💥2X as potent💥 at lowering my LDL cholesterol (LDL-C) compared to high-intensity statin therapy!

What you NEED to know...

👉This was a metabolic demonstration, a 'do not do this at home' experiment that makes no 'health' claims about cookies or cholesterol.

👉The purpose was to BOLDLY test a prediction of the Lipid Energy Model #LEM, i.e. that adding in carbs, including in the from of an Oreo cookies 'addition' (not carb-fat swap) would lower LDL-C in an LMHR on a #keto diet

Why Oreos? ... It's (productively) provocative! 😱

Research on #cholesterol on #keto diets and the #LEM and #LMHR phenotype has so much to teach us about human lipid metabolism! ...

But how do I (we) communicate the scientific 'awe' that we feel to the greatest number of people (as well as force a conversation about #LMHR and #LEM that needs to happen)? ... A dramatic demonstration designed to turn heads might work!

It's not 'just click bait' ... it's 'legit-bait'

I want YOU to feel the 'shock and awe' I feel every day studying this topic. And I want you to engage in the research journey.

What you need to do... or should do... 🙏PRETTY PLEASE 🙏!

👉PLEASE WATCH 👀 VIDEO ABSTRACT here (<8 min): https://t.co/NYI7XrWZ2n

👉 SHARE THIS LINK to the paper itself in a quote RT or original Tweet of your own: https://t.co/3Ap9zKn3XJ ... doing so helps promote the work and provoke the discussion

... and feel free to tag in your favorite influencers (or least favorite 😉)...

A HUGE thanks to the senior author and expert lipidologist @Lipoprotein for his guiding wisdom, insightful thoughts, and always open and curious mind.

And to @realDaveFeldman, my friend, research wife, and the '#LEM daddy'

Finally... there will be a LOT of coverage of this experiment. Keep in mind, we are not making any health claims, but through a dramatic demonstration, highlighting an uncomfortable tension that arises from a prediction of the Lipid Energy Model, and that is consistent with prior data (7+ papers, including 'highest tier' data like our recent meta-analysis of 41 RCTs).

Science is supposed to embrace such uncomfortable questions... so, join us in being curious and advocating for much needed research on #LEM and #LMHR so we can make sense of what observations like this really mean... STAY CURIOUS 🤔

[Happy&Healthy @solitasantander]

@nicknorwitz @jimgris @realDaveFeldman @Lipoprotein 🤮all for science! it is appreciated.

[Happy&Healthy @solitasantander]

🙌🙌🙌

[Nick Norwitz MD PhD @nicknorwitz]

🚨#OreoVsStatin - PUBLISHED!🚨
https://t.co/3Ap9zKn3XJ

@Oreo cookies were 💥2X as potent💥 at lowering my LDL cholesterol (LDL-C) compared to high-intensity statin therapy!

What you NEED to know...

👉This was a metabolic demonstration, a 'do not do this at home' experiment that makes no 'health' claims about cookies or cholesterol.

👉The purpose was to BOLDLY test a prediction of the Lipid Energy Model #LEM, i.e. that adding in carbs, including in the from of an Oreo cookies 'addition' (not carb-fat swap) would lower LDL-C in an LMHR on a #keto diet

Why Oreos? ... It's (productively) provocative! 😱

Research on #cholesterol on #keto diets and the #LEM and #LMHR phenotype has so much to teach us about human lipid metabolism! ...

But how do I (we) communicate the scientific 'awe' that we feel to the greatest number of people (as well as force a conversation about #LMHR and #LEM that needs to happen)? ... A dramatic demonstration designed to turn heads might work!

It's not 'just click bait' ... it's 'legit-bait'

I want YOU to feel the 'shock and awe' I feel every day studying this topic. And I want you to engage in the research journey.

What you need to do... or should do... 🙏PRETTY PLEASE 🙏!

👉PLEASE WATCH 👀 VIDEO ABSTRACT here (<8 min): https://t.co/NYI7XrWZ2n

👉 SHARE THIS LINK to the paper itself in a quote RT or original Tweet of your own: https://t.co/3Ap9zKn3XJ ... doing so helps promote the work and provoke the discussion

... and feel free to tag in your favorite influencers (or least favorite 😉)...

A HUGE thanks to the senior author and expert lipidologist @Lipoprotein for his guiding wisdom, insightful thoughts, and always open and curious mind.

And to @realDaveFeldman, my friend, research wife, and the '#LEM daddy'

Finally... there will be a LOT of coverage of this experiment. Keep in mind, we are not making any health claims, but through a dramatic demonstration, highlighting an uncomfortable tension that arises from a prediction of the Lipid Energy Model, and that is consistent with prior data (7+ papers, including 'highest tier' data like our recent meta-analysis of 41 RCTs).

Science is supposed to embrace such uncomfortable questions... so, join us in being curious and advocating for much needed research on #LEM and #LMHR so we can make sense of what observations like this really mean... STAY CURIOUS 🤔

[Happy&Healthy @solitasantander]

@DoctorTro 👏👏👏👏

[DoctorTro @DoctorTro]

Proud to share our clinic’s results:

💥~16% weight loss at one year💥

Massive reductions in:
•Triglycerides
•CRP
•Blood pressure
•Liver enzymes

Massive increase in:
•HDL

No change:
•LDL

While deprescribing ~60+ medications including GLP1 drugs

The amazing team:
@LauraBuchananMD
@MarykDugandzic
@AmyDee1001
@BrianWiley_
@carbaddictcoach
@MattCalkinsMD
@LowCarbBeast

These results were presented at @TheSMHP Boca and this data will be submitted for publication very soon.

[Happy&Healthy @solitasantander]

Por favor lean este hilo sobre Estatinas.

[Marion Holman @holmanm]

Some of you may have already seen this, but for any new followers, or those who still think it's a good idea to artificially lower cholesterol with a Statin drug, this may be for you !

[Suneel Dhand MD @DrSuneelDhand]

Eat more protein.

Over 90 percent of people I meet don’t eat anywhere near enough.

PLEASE ignore the mainstream establishment who claim we are all “eating too much protein”. They are serial liars and committed to keeping the population as weak and dependent as possible.

[Happy&Healthy @solitasantander]

Lean el hilo desde un principio

[Marion Holman @holmanm]

9/9 Cardiovascular Disease is caused by infection, inflammation, hyperinsulinemia and oxidative stress. The focus on cholesterol is, as it always has been, bizarre. I’m also not a firm believer that your liver manufactures Cholesterol to kill you !

[Happy&Healthy @solitasantander]

Qué bue o que enmendaste

[Gerardo Moscatelli @gemoscatelli]

@lowcarbGP @BDA_Dietitians @DiabetesUK I went through chemo in 2021 eating lots of cereals with milk and sweet fruit, drinking fruit juices convinced that I was eating the healthiest food, ended up with visceral fat and liver inflammation. Fixed it with ketogenic diet and fasting tks to the advise of Drs posting here

[Dr David Unwin @lowcarbGP]

Eating a lot of fruit is a bad idea if you have fatty liver: An RCT @BDA_Dietitians @DiabetesUK It’s because fruit is a source of sugar and excess sugar is turned to fat (triglyceride) in the liver

[Happy&Healthy @solitasantander]

Algunas referencias bibliográficas relacionadas con la discusión "óreo/estatinas"

[Nick Norwitz MD PhD @nicknorwitz]

I have a will continue to build research relationships with experts in the field. I’m proud to count Professors William
Cromwell @Lipoprotein, Ronald Krauss, Anatol Kontush, Matthew Budoff, among others, #LMHR-interested ‘luminaries.’ See 8 select references below (one of which you are my second author on, as you know) if you need a reminder. However, the reality is that there’s a concerted effort to ignore (and/or suppressor even distort; eg Circulation abstract) this area of work. Call me an impatient young man, but I don’t consider the pace of progress sufficient, nor will I tolerate the condescension executed by some. Thus, I’m more than happy to take advantage ‘outside the box thinking’ to leverage my resources and force discussions that need to happen. And, it’s working. You may be surprised by the numbers of senior and resident physicians who have reached out to me in the past two days because they’re now aware of #LMHR and #LEM because of #OreoVsStatin. So, if you’re concerned about my relationship building, not to worry, this project is only accelerating the process. You, @MichaelMindrum, are of course welcome to join us @realDaveFeldman @AdrianSotoMota. But if you aren’t going actively help push for more research going forward, I’ll just say I don’t respond well to empty condescension. The door remains open if you want to actively participate in the research

For some pleasure reading:
• Norwitz NG, Cromwell WC. Oreo cookie treatment lowers LDL cholesterol more than high-intensity statin therapy in a lean mass hyper-responder on a ketogenic diet: A case study crossover experiment. Metabolites. 2024
•Soto-Mota A, Flores-Huardo Y,  Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. 2024; American Journal of Clinical Nutrition  
•Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Frontiers in Endocrinology. 2023
•Norwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022
•Feldman D, Huggins S, Norwitz NG. Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower LDL cholesterol: the cholesterol drop experiment. Current Opinion in Endocrinology and Diabetes. 2022
•Norwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites. 2022
•Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Current Developments in Nutrition. 2022
•Norwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Frontiers in Endocrinology. 2022

[Happy&Healthy @solitasantander]

Ciencia! Abra su mente

[Douglas Ritz @douglasritz]

@DominicDAgosti2 @WStoneReports “Science is racing to understand why"

Indeed.

As Stephen Cunanne said long ago, your brain will preferentially utilize ketones even when there is an overabundance of glucose available. There’s probably a reason for it.

That goes for your heart and kidneys as well.

[Dominic D'Agostino @DominicDAgosti2]

Great article @WStoneReports! "Patients say keto helps with their mental illness. Science is racing to understand why"
https://t.co/6ZdUkD6EJn

[Happy&Healthy @solitasantander]

Nuevamente la hiperinsulinemia!!!

[Benjamin Bikman @BenBikmanPhD]

Yes. Of course, the elevated FFA from the hypertrophic adipocytes are only problematic in this state because of the elevated insulin. That’s the important difference between the elevated FFA of an exercising state and that of a metabolic syndrome state. If insulin is low, tissues would simply burn the FFA. But that’s not possible with elevated insulin. In contrast, the tissues are forced to store it. It’s all about insulin!