Sophia Burick

High-throughput exploration of enzyme sequence-function space @fordycelab | @Stanford Biophysics PhD

[Sophia Burick @sophiaburick]

Great work from @Xiaowei0402 and team, who I had the privilege of learning from during my rotation in @SynBioGaoLab. A neat approach to engineering functional proteins with defined properties like intracellular stability and low immunogenicity.

[Xiaowei Zhang @Xiaowei0402]

We deimmunized a clinical CD19 CAR binder with experimentally detected HLA-I epitope depletion while retaining tumor killing, and rescued a secreted protease to function in the cytosol.

Both done with one unified design framework: ProVADA.

How it works and what we tested 🧵 (1/11)