Søren Grubb

Biologist👩‍🔬, physiologist🔬, electrophysiologist⚡, cardiovascular scientist❤️, neuroscientist🧠 @sorengrubb.bsky.social

[Søren Grubb @SorenGrubb]

Preprint! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 https://t.co/iR0PJgR7Vo
🧵1/8

[Osama Harraz @OsamaHarraz]

PIP2 corrects an endothelial Piezo1 channelopathy | @PNASNews https://t.co/kdA5Wepb8P

[allen institute @AllenInstitute]

Electron microscopy is @nature's Method of the Year! 🧠🔬🏆

@naturemethods shares why MICrONS and FlyWire are proof that #ElectronMicroscopy is helping us gain a deeper understanding of the brain and its incredible complexity: https://t.co/ulrxfdJKxJ

#studyBRAIN

[Søren Grubb @SorenGrubb]

@drseanmullen @rust_ruslan Yes, that would be interesting.

[Søren Grubb @SorenGrubb]

Also thanks to @helenelab2020 for access to the CA1 dataset!

[Søren Grubb @SorenGrubb]

Preprint! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 https://t.co/iR0PJgR7Vo
🧵1/8

[Søren Grubb @SorenGrubb]

We want to acknowledge the amazing #OpenScience #ElectronMicroscopy datasets by @alleninstitute, @HHMIJanelia, and our other sources! This work is a collaboration between myself @UCPH_health, @amreenmughal1 and @VanshikaChaddha @NIH, and Carolyn and Jennifer @HHMIJanelia.

[allen institute @AllenInstitute]

Open science resources, like the MICrONS dataset, helps @SorenGrubb and other researchers explore more of the brain's mysteries. #OpenScienceWeek

[Søren Grubb @SorenGrubb]

@HaoYin20 @_JCBFM There is more on the way 😉

[Søren Grubb @SorenGrubb]

@HaoYin20 @_JCBFM 🙏

[Hirase lab@KU @Hiraselab_KU]

We are excited to report:
Cerebral blood flow is modulated by astrocytic cAMP elevation independently of IP3R2-mediated Ca2+ signaling in mice
Vittani et al. PNAS (2025)
https://t.co/MgUKtQPA9P

[Søren Grubb @SorenGrubb]

@HaoYin20 @ClaireDessalles Now the videos are there!

[Søren Grubb @SorenGrubb]

🐭🧠 #PrecapillarySphincters (PS) at the #arteriole–#capillary junction rapidly dilate ~30% in seconds during #SensoryStimulation—regulating #capillary #BloodFlow dynamically. Here we investigated whether they protect downstream microvessels during abrupt #BloodPressure surges 🧵

[GeroScience @GeroScienceAGE]

📢Breaking: New Open🔓 Access Publication

Brain precapillary sphincters modulate myogenic tone in adult and aged mice by Christina L. Fjorbak & Søren Grubb (@SorenGrubb) et al.

https://t.co/NUVhoKwrn3

#aging #pericyte #Hypertension #precapillarysphincter #autoregulation #myogenicresponse

[Søren Grubb @SorenGrubb]

@MSamak_PhD Thank you! 🙏