Souvik Seal

Assistant professor at MUSC Biostatistics and Hollings Cancer Center | Previously PostDoc at CU Anschutz and PhD from UMinnesota

[BioTender @Junioryu136689]

Picking marker genes along a developmental trajectory is trickier than it sounds: supervised pseudotime methods use stage labels but don't flag which genes drive each stage-to-stage change, while unsupervised trajectory methods find trajectory genes but never tie them back to observed stages. FusedFCR bridges the gap — a regularized forward continuation-ratio model that represents cell progression as a sequence of conditional transitions, with a fusion penalty letting nearby transitions share similar gene effects.

Applied to mouse pancreatic beta-cell differentiation (7 timepoints) and human trophoblast differentiation (4 timepoints), it found biologically interpretable genes tied to specific developmental transitions, with stage-classification accuracy matching or beating alternatives — pinpointing not just which programs change, but exactly when.

https://t.co/c96sGE0Mnx

[Lisandro Martinez @LisandrMartinez]

Con el dolor en el alma por no haber podido traer la copa que todos merecíamos, pero con el orgullo a flor de piel por esta camiseta, por mis compañeros, el cuerpo técnico, los directivos, el cuerpo médico, los cocineros, los utileros y por cada persona que estuvo involucrada para que todo esto funcionara de la mejor manera. Y, por sobre todo, por ustedes, que nos hicieron llegar todo su amor, toda su fuerza, esa pasión que tanto nos caracteriza y la unión de un país que espero perdure en el tiempo.

Quiero felicitar a España por su merecido título.

Y a nuestra gente quiero decirle que el resultado no define el camino recorrido. Atravesamos adversidades, hicimos posible lo que parecía imposible y nunca buscamos excusas, solo encontramos razones para seguir. Defendimos nuestros colores mucho más allá de la cancha y compartimos momentos inolvidables en la Selección, junto a nuestras familias y con el apoyo incondicional de todos los argentinos. Siempre será un enorme orgullo representarlos.

Recuerden que “la caída de los grandes es la felicidad de los mediocres”.

Muchas gracias a todos. Cuidemos nuestro país. 🙏🏼

¡Te amo, Argentina! 🇦🇷

[Souvik Seal @souvikseal]

@aurem22372 @lolishmool @shitpost_game Says the guy with anime pfp

[biorxiv_pathology @biorxiv_pathol]

Differences in T-cell counts and neighborhood patterns in human colorectal adenomas and sessile serrated lesions https://t.co/8584TveJrt #biorxiv_pathol

[bioRxiv Bioinfo @biorxiv_bioinfo]

CBKMR: A Copula-based Bayesian Kernel Machine Regression Framework for Optimal Marker Detection in Omics Data https://t.co/xSQQXbuaJp #biorxiv_bioinfo

[SciencesNetwork @SciencesNetwork]

GRASS-NB: Group-structured variable selection for spatial negative binomial data with applications to cancer registry and spatial omics
https://t.co/KdOYXADvtp

[JAMA Oncology @JAMAOnc]

Public awareness of #HPV, its vaccine, and its #cancer links is low in the US, especially in the Midwest and South, contributing to suboptimal vaccination rates in these regions. https://t.co/b0LYZ69Scx @ashish_deshmuk

[bioRxiv Bioinfo @biorxiv_bioinfo]

SpaceBF: Spatial coexpression analysis using Bayesian Fused approaches in spatial omics datasets https://t.co/nLL79FeNfL #biorxiv_bioinfo

[Souvik Seal @souvikseal]

@chetrisunil11 @ZwebackHD

[Anil Bera @AnilBer75410115]

It pains me a lot to inform you that Dr. C. R. Rao passed away this evening (August 22, 2023). He would have attained the age of 103 on September 10th. We have lost not only one of the Greatest Statisticians but also a Great Man.

[antisense. @razoralign]

SpaceANOVA: Spatial co-occurrence analysis of cell types in multiplex imaging data using point process and functional ANOVA https://t.co/dYeTP6Y62T

[bioRxiv Bioinfo @biorxiv_bioinfo]

SpaceANOVA: Spatial co-occurrence analysis of cell types in multiplex imaging data using point process and functional ANOVA https://t.co/SjRm1D4akH #biorxiv_bioinfo

[bioRxiv @biorxivpreprint]

SMASH: Scalable Method for Analyzing Spatial Heterogeneity of genes in spatial transcriptomics data https://t.co/A1dqZfItw2 #bioRxiv

[Souvik Seal @souvikseal]

https://t.co/HcC5jx7MTI

[Souvik Seal @souvikseal]

A poet getting justice. Never forget the pain it took. #ArgentinaVsFrance

[ASA Section on Statistics in Genomics and Genetics @ASA_SSGG]

Our past char Dr. Katerina Kechris shared some insight about Justice, Equity, Diversity, and Inclusion in our recent newsletter. Please check out here as well!

@AmstatNews #Justice #newsletter #Genetics #Diversity #inclusion

[Souvik Seal @souvikseal]

Prof. Sau Ghosh motivated me to pursue Biostatistics. Along with all the fun interactions, I will forever remember the long chat we had in my final days at ISI Kol, where he tried to explain to a clueless newbie how the world of research and academia works. Rest in peace sir.

[IGES @genepisociety]

IGES is saddened at the unexpected passing of Professor Saurabh Ghosh on October 3rd. We remember his enthusiasm for scientific research, and also his broad sharing of knowledge and inclusion of others. We send heartfelt condolences to his family, friends & the genetics community

[Souvik Seal @souvikseal]

@ghoshd Barring a few such experiences, it has been a fabulous ride. Thank you!

[Noor Pratap Singh @PratapNoor]

Bulk RNASeq vs Single-Cell

[Souvik Seal @souvikseal]

@ghoshd @nataliexdean The whole panel did such an amazing job!