Chris Spicer

Lecturer in Chemistry @chemistryatyork. Designing new bioconjugates and biomaterials for tissue repair.

[Chris Spicer @spicerlab]

Our latest paper from Lydia and @XeniaKSS is out in JACS Au! We wanted better reagents for selectively labelling protein N-termini, so looked at how functionalisation affected each step of the complex equilibrium, leading to faster and more stable probes!
https://t.co/ROvseE8Ixi

[Dr Wade F. Petersen @PetersenChemLab]

Keep an eye out for the last couple from the group!😎🦾

Latest instalment: Phathu’s PhD work on enantioselective a-amination just out in @JOC_OL (https://t.co/oJP7X9cT2W). Congrats to Phathu and the entire team!🎉🎉 For more from this guy, keep an eye out on the @spicerlab!

[Chris Spicer @spicerlab]

Our latest preprint is out - Lydia took a deep dive into the chemistry of pyridinecarboxaldehydes to try and find improved reagents for labelling protein N-termini. Spoiler: we think we found some design criteria that allow us to achieve just that!
https://t.co/rurxfGgU5n

[pashucklab @pashucklab]

Hi! I am excited to share a new paper led by @RozansSam We all love peptides and put them in biomaterials, but don't often think about how stable they are during culture. Sam and co-workers synthesized a series of peptide libraries and incubated them with different cell types.

[Chris Spicer @spicerlab]

New preprint, where we use functionalised peptides as catalysts for proximity labelling of proteins - with the ability to screen libraries of peptides for protein binding, we think this could be a really versatile tool for site-selective modification.
https://t.co/OFVmx8GGpf

[Chris Spicer @spicerlab]

@professor_dave At 11 C it was at least 10 degrees below a temperature I would have considered that at!

[Chris Spicer @spicerlab]

Lovely day out on the North Yorkshire coast yesterday to say goodbye to our fantastic Mchem students Perisa and Alicia. Best of luck for your next steps!

[Chris Spicer @spicerlab]

@Bill_G_Grey I left that to the younger members of the group!

[Chris Spicer @spicerlab]

Our group had a fantastic time showcasing hydrogel chemistry (beautiful alginate beads and 'fake snow'!) to the next generation of budding scientists at @YorkFestofIdeas last week, along with the team of @professor_dave and @YBRI_UoY. Great to interact with the York community

[York Biomedical Research Institute @YBRI_UoY]

Make your way to Acomb Library today to have a go at making your own hydrogel and learn how they are used in medicine!

#getinvolved #science #outreach @YorkFestofIdeas

[Dr Will Unsworth @UnsworthChem]

Mixed feelings to announce the first paper to come out from our good friend Prof Paul Clarke's lab since he died last year. Elegant and creative total synthesis work of the type Paul was always best known for.
@ChemistryatYork @ChemCommun @Ian_Fairlamb
https://t.co/yUVdCi97bB

[Chris Spicer @spicerlab]

@Cochrane_lab @LukGroup @LondonMarathon @ChemistryWorld Congrats Stephen, was keeping an eye out for you and thought a man in a lab coat would be obvious, but you must have been going too quick for us!

[York Biomedical Research Institute @YBRI_UoY]

#NewPaper from @spicerlab and colleagues @ChemistryatYork

'Expanding the scope of the successive ring expansion strategy for macrocycle and medium-sized ring synthesis: unreactive and reactive lactams' #antibacterial #assays #ecoli

https://t.co/Ci5BnqrBde

[Chris Spicer @spicerlab]

Also 2 new entries for journal bingo, which I know @UnsworthChem will approve of

[Chris Spicer @spicerlab]

Nice to be able to play a small role in supporting the work of good friends of the group in 2 papers this week. The first led by @theSeriousLab with @XeniaKSS just out in PLOS Biology on microfabrication platforms for cell culture

https://t.co/tZhjg05utd

[York Biomedical Research Institute @YBRI_UoY]

#NewPaper from @spicerlab and colleagues @ChemistryatYork

Low-cost, versatile, and highly reproducible microfabrication pipeline to generate 3D-printed customised cell culture devices with complex designs #cellculture #bioengineering

https://t.co/U6Xh3X8y01

[Chris Spicer @spicerlab]

And the second led by @UnsworthChem and his team expanding their ring expansion chemistry. Big congratulations to PhD student Owen, joint supervised with Will and Martin Fascione @ChemBiolYork on what I'm sure will be the first of many papers!

https://t.co/kCwL6JVZoQ

[Chris Spicer @spicerlab]

@alex_paynedwyer @Steve_Quinn_Lab Thanks Alex - happy to chat about it, we've got some of the days sat in the lab if want to give it a go

[Chris Spicer @spicerlab]

Our new paper has been a labour of love so delighted to see it out! We show that strain-promoted cycloadditions can take place in lipid membranes, providing a potentially valuable tool to study membrane proteins, lipid dynamics, and bilayer transport
https://t.co/FrUg2dIdjn

[Angewandte Chemie @angew_chem]

Strain-Promoted Cycloadditions in Lipid Bilayers Triggered by Liposome Fusion (Molly M. Stevens and co-workers) @imperialcollege #OpenAccess https://t.co/T6qSMV7Kym

[Chris Spicer @spicerlab]

Congratulations to the group's second PhD student Laetitia on her graduation last week! The first one I've been able to attend at @ChemistryatYork so a very proud supervisor moment, and lovely to see some of our undergrad students back to celebrate as well

[Chris Spicer @spicerlab]

Great work from @ChemBiolYork PhD Abby from the Fascione group! Must read for glyco scientists

[Abby Walklett @abby_walklett]

Absolutely delighted that my first first author paper has been published in @angew_chem! We've identified the founding member of a previously unreported glycosyltransferase family (GT118); a retaining pseudaminyltransferase, KpsS1, from A. baumannii ACICU! https://t.co/WkcYX3fZw6