Matty Cheese

Medicinal Chemist

[Matty Cheese @spin989]

@showstopper Rocky Horror, I'm creating a micro pig with a blonde hair and a tan, he's good for relieving my, tension

[Chris Packham @ChrisGPackham]

Hello @Keir_Starmer I hope you’re having a good start to Christmas . I didn’t know who else to write to so I’m hoping you can help . Please make some calls & get this poor woman out of prison for Christmas . This doesn’t reflect well on the UK . Thanks #loveactually Please RT

@DavidLammy @AngelaRayner @Ed_Miliband

[Matty Cheese @spin989]

@felixwhite @BBCiPlayer @BBCSport @MLBEurope Loving the baseball, the height of the strike box, how is it defined?

[Matty Cheese @spin989]

@SkyCricket It is possible to explain to the commentators the difference between margin of error and umpire's call. Umpire's call is not margin of error!

[Matty Cheese @spin989]

@AshandyTemi 56+30 is 86, minus 1

[Matty Cheese @spin989]

@ElonMNews A

[Matty Cheese @spin989]

@rosenbaum6 Do you include the dates these were done? Sure the last poll before the vote was a yougov that showed surprising 5 point drop off. Clear trend down for labour over campaign and maybe super majority/complacency did work, eg Lab will win so I'm safe to vote Green?

[Matty Cheese @spin989]

@KRHornberger @GntlmnScientist Ironically, I think if you sent it to people in Britain, most would not understand what it means. We are not taught about the American revolution in school at all. Plus it's general election day so they would think it has something to do with that.

[Supertanskiii @supertanskiii]

Led by Donkeys slowly unveiling a sign showing Putin saying “I ♥️ Nigel” during one of Farages Reform hate rallies, is one of the best things that I’ve ever seen.

Absolute fucking legends!

[The Labour Party @UKLabour]

While so many people lost loved ones without saying goodbye, the Tories were partying.

Never forget.

[Bella 🕊️ @Bella_healtheco]

@SimonPease1 Can you spread the message to all your friends: we are looking for volunteers to help us in Fareham @ Waterlooville to help oust Suella….any help would be massively appreciated 🙏🏾

[Matty Cheese @spin989]

@KRHornberger Keep fighting the good fight

[Matty Cheese @spin989]

@elonmuskADO No

[Matty Cheese @spin989]

@cricket_badger Nope

[udaibanerji @udai_banerji]

Messing with (cancer cell) stress. PK-PD and toxicity of the dose escalation cohort of NXP800 (NCT05226507) Abst CT111 at #AACR2024. Target engagement confirmed, next steps to evaluate efficacy in ARID1A mutated tumours. @ICR_London @TheRMH @ECMC_UK @RMresearch_

[Matty Cheese @spin989]

@KRHornberger But also whether t>EC50 or AUCu is the main driver, compound optimisation would still be best served by make more potent and/or reduce Clint,u.

[Matty Cheese @spin989]

@KRHornberger Lots of numbers in there and maybe I have misunderstood, but in simple brain, Cav,u/EC50 improves as a descriptor as target half life gets longer, which is intuitive and useful as is more straightforward for comparing early analogues than Cmin,u/EC50.

[Martin Lewis @MartinSLewis]

There's a lot of confusion about inheritance tax. So feel free to share the video below with anyone who might not know how it really works :)

[Matty Cheese @spin989]

@KRHornberger I am still not convinced by guidelines, other than to keep a slide simple. I like the tradeoffs, nice correlation for logD and cyp3a4 metabolism and negative for passive permeability, so here is the lipophilicity space for this chemotype, then explain outliers.